Used for centuries in spiritual ceremonies, psychedelic drugs such as LSD have become known to Western society as fuel to the 1960s counterculture movement. But since they first sparked the interest of researchers in the late 19th century, there has also been a keen interest in their medical use. Initially, they were regarded as tools for psychiatrists to study the effects of a model psychosis they were thought to elicit, but focus has since shifted towards directly treating patients in psychedelic-assisted therapies. These have shown great promise for treatment of depression, addiction and anxiety, but why some patients respond better than others is still unclear. For this month’s science ramble, let’s look at the history of psychedelics in medicine, and a recent study that may explain differences between patients based on small variants of the underlying receptors in the brain.
DISCLAIMER: This episode features short snippets of “Tomorrow never knows” by the Beatles, “Eight miles high” by the Byrds and “Purple Haze” by Jimi Hendrix. I do not have copyright for these tunes (do check them out on any listening platform, if you want to hear the full versions, I recommend!), but my use here falls under “fair dealing” under UK copyright law, which permits use for “research and private study, criticism or review, or news reporting”.