The Sheekey Science Show

In this video I spoke with Vijay Yadav, Assistant Professor at the Department of Genetics and Development at Columbia university researching functional connections between human metabolism and disorders. Earlier this year his team published on the role of taurine and how supplementation in a mouse models improved many markers of health. Here we discuss Vijay’s interest and research further.

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In this discussion i spoke with Cole Delyea, a fellow Youtuber  @InvestigateExploreDiscover , with a background in immunology. However, here we discuss Cole’s involvement with ResearchHub - a platform that is changing the way in which scientific research can be accessed and funded, as you will shortly find out.

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In this video i spoke with Dr Brandon Berry, a current Post-Doctoral fellow at the University of Washington, where he is developing and using tools to understand the function of mitochondria and their link with diseases and aging. Here, we discuss these interests further and the results from his latest publication one tool, termed 'mitochondria-ON', extended worm lifespan. 'Mitochondria-ON' rejuvenates the mitochondrial membrane potential when exposed to light and all-trans-retinal using optogenetics.

Find Brandon on Twitter - https://twitter.com/mitobrandon 
Research papers - Berry, B.J., Vodičková, A., Müller-Eigner, A. et al. Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan. Nat Aging  (2022). https://doi.org/10.1038/s43587-022-00340-7 
Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance https://www.embopress.org/doi/full/10.15252/embr.201949113 
Berry, B.J., Kaeberlein, M. An energetics perspective on geroscience: mitochondrial protonmotive force and aging. GeroScience 43, 1591–1604 (2021). https://doi.org/10.1007/s11357-021-00365-7

Find me on Twitter - https://twitter.com/EleanorSheekey 

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Nik Money is Professor of Biology and Western Program Director at Miami University in Oxford, Ohio. Referring to himself as “The mycologist”, Nik is indeed an expert on mycology and has authored a number of books that celebrate the diversity of the microbial world. In his research at Miami, he has pioneered the use of high-speed video microscopy to understand the explosive mechanisms used by fungi to launch their spores into the air. In this discussion we discuss what fungi are, whether they are intelligence and how compounds found within mushrooms could affect our health and our brain. Hope you enjoy. 

Nik's website - https://www.themycologist.com/ 

Find me on Twitter - https://twitter.com/EleanorSheekey 

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In this video I chat with Peter Lidsky, a postdoctoral fellow at the University of California, San Francisco (UCSF), where he works on his interests in the role of viruses in aging and evolution.
Before that, Peter studied enteroviruses and then moved to Switzerland, where he joined the laboratory of Christian Lehner at the University of Zurich. There, he switched his focus to Drosophila melanogaster, a model organism for studying gene regulation and development. In 2017, Lidsky moved to the US and joined the laboratory of Raul Andino at UCSF. He has been involved in several projects but here we chat predominantly about his 'Pathogen Control Strategy' to explain why aging evolved.

Peter's Twitter: https://twitter.com/LidskyPeter 
Find me on Twitter - https://twitter.com/EleanorSheekey 

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In this video I spoke with Samir Okasha, Professor of Philosophy of Science at University of Bristol. He has interests in the 'levels of selection' question in evolutionary biology, and the related issue of individual versus group conflicts of interest. Here, we discuss these interests and the broader role that philosophy of biology plays.

Samir's profile - https://research-information.bris.ac.uk/en/persons/samir-okasha 

Find me on Twitter - https://twitter.com/EleanorSheekey 

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Today’s discussion features Benjamin Anderson, a friend of mine from St. Louis and who i would consider a life long learner. He has previously built WAND, an Uber-like platform for booking housekeepers and more recently is an executive producer for the Vance Crowe podcast. However, here i talk with Ben about his independent research in aging and bioelectric networks through independent research and why he thinks this may be a good intervention point for longevity. 

Links:
Benjamin's Website: https://www.thebenjam.in/
Find Benjamin on Twitter: https://twitter.com/BenAnderson421
Bioelectricity & Aging Paper: https://www.liebertpub.com/doi/10.1089/bioe.2023.0013
Open Source PrePrint: https://www.thebenjam.in/research/bioelectricity-causal-factor-aging/

Find me on Twitter - https://twitter.com/EleanorSheekey 

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Here, I chat with Ryan Murray, a current PhD student at North Eastern University who has been using an innovative form of gene editing, called base editing, to engineer T-cells to target cancer cells. His editing approach involves making the T-cells allogeneic, more effective and stealthier! 

Ryan's Twitter - 
Ryan's preprint - https://www.biorxiv.org/content/10.1101/2023.08.03.551705v1.full 

Find me on Twitter - https://twitter.com/EleanorSheekey 

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Tae Seok Moon is an associate professor of energy, environmental and chemical engineering at Washington University in St. Louis. He is an expert in synthetic biology, metabolic engineering, and protein engineering. Using synthetic biology, Tae Seok has been engineering probiotic bacteria for medical applications, bacteria to consume plastic and building biocontainment circuits and other global problems.

Find Tae Seok on Twitter - https://twitter.com/Moon_Synth_Bio 
Tae Seok runs a YouTube channel hosting symposiums - https://www.youtube.com/@UCTkyl4Uw1NlpuLCeP4Zi8aA 

Find me on Twitter - https://twitter.com/EleanorSheekey 

Support the channel 
through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB 
through Patreon - https://www.patreon.com/TheSheekeyScienceShow

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