A landscape of darkness, the distance muzzle flashes of a shootout. Violence, brutality. The Sisters Brothers opens like many westerns before it, but then it spirals into oddball directions as two lowly, dangerous, comic relief henchmen take center stage and throw the rest of the genre into sharp relief. John C. Reilly and Joaquin Phoenix star as Eli and Charlie Sisters, two hired guns working for an unseen commodore, who sends them on a quest spanning the American west in 1851.