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Date: June 3rd, 2017
Reference: Sierink et al. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet August 2016.
Guest Skeptic: Dr. Marcel Emond is an Associate Professor, Laval University, Emergency Physician at the Level 1 Trauma Center of the CHU de Québec, a Senior Clinician-Scientist, Chair of CAEP Trauma and Injury prevention committee, BEEM faculty member and the host of SGEM Global French.
Case: A 53-year-old woman in good health is brought in by ambulance after a motor vehicle collision. She did not lose consciousness but did bump her head. Her main complaint is chest pain with difficulty breathing. She is tachycardic, tachypnic and has some mild abdominal pain. You suspect a flail chest on your clinical examination. A FAST examination is performed and is negative.
Question: Should trauma patients get an immediate total-body (pan scan) CT or should you do usual X-rays followed by selective CT scanning?
Background: When we assess head or cervical spine injuries there are good clinical decision tools available to Emergency Physicians to guide our care (Canadian CT Head Rules and Canadian C-Spine Rules).
However, when we assess major trauma that includes chest, abdominal and pelvic trauma, the initial radiologic evaluation is left to the treating physician’s judgement. There is no validated clinical decision tool to help guide our decisions.
Many studies (most retrospective) have assessed the use of pan scanning as an initial radiologic evaluation. Huber-Wagner et al (Lancet 2009) showed a mortality reduction in a retrospective database study of patients who have had a pan scan. The NNT varied from 17 to 32 according to the injury severity.
A systematic review by the authors of the present study confirmed a possible benefit of the pan scan, but it showed a need for a well-designed, large, prospective randomized clinical trial with patient oriented outcomes (Sierink et al 2012).
Reference: Sierink et al. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet August 2016.
* Population: Adults (18 years or older) with severe injury, suspicion of life-threatening injuries or compromised vital signs.
* Exclusions: Pregnant, referred from another hospital, low-energy trauma with blunt injury mechanism, stab wound in only one body region, and patients too unstable to undergo a CT scan who require CPR or immediate operation because death is imminent
* Intervention: Immediate total-body CT scan (vertex to pubic symphysis)
* Comparison: Standard ATLS guideline directed workup that included chest and pelvic x-rays, FAST scan and followed by selective CT scans of individual body regions.
* Outcome:
* Primary: In-hospital mortality at initial hospital or secondary hospital if transfer occurred
* Secondary: 24 hour and 30 day mortality, imaging time, time to diagnosis, length of stay (LOS) in the trauma room or ICU, number of days of mechanical ventilation. cumulative radiation dose, serious adverse events, transfusion requirements, number of missed injuries and hospital costs.