The Tim Ferriss Show Archives - The Blog of Author Tim Ferriss

The Tim Ferriss Show Archives - The Blog of Author Tim Ferriss

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The Tim Ferriss Show Archives - The Blog of Author Tim Ferriss episodes

  • Q&A with Tim — The Art of Male Friendship, Mini-Retirements, Higher-Resolution Living, Reinvention in The Age of AI, and More (#877)

    In this wide-ranging Q&A, I explore reinvention, enduring skills for the age of AI, friendship, mental health, fitness, language-learning, privacy, cognitive longevity, and more.

    Please enjoy!

    This episode is brought to you by:

    • Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses
    • Momentous high-quality creatine for cognitive and muscular support
    • Helix Sleep premium mattresses
    • Wealthfront high-yield cash account
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      Q&A with Tim — The Art of Male Friendship, Mini-Retirements, Higher-Resolution Living, Reinvention in The Age of AI, and More<iframe src="https://www.art19.com/shows/58dacbdc-646e-4585-9914-19c3de11d1ba/episodes/b7244dd5-291f-4ab3-9d1b-8ea015a8d59e/embed?type=micro" style="width: 100%; height: 30px; border: 0 none;" scrolling="no"></iframe>
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      Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

      Transcripts
      • This episode
      • All episodes
      • Show Notes
        Recommended Reading
        • Can TMS Therapy Be Delivered in One Day? Dr. Jonathan Downar Explains the Evidence | Neurocare Group
        • Fear-Setting: The Most Valuable Exercise I Do Every Month | Tim Ferriss
        • “The Limits of My Language Mean the Limits of My World” — Ludwig Wittgenstein | Wikiquote
        • 1,000 True Fans | Kevin Kelly
        • Tech Investors and Longevity Influencers Back Neko Health’s Expansion | The New York Times
        • There Are Always More Than Two Options | Derek Sivers
        • 12 Rules for Learning Foreign Languages in Record Time — The Only Post You’ll Ever Need | Tim Ferriss
        • Books
          • The Anxious Generation: How the Great Rewiring of Childhood Is Causing an Epidemic of Mental Illness by Jonathan Haidt
          • Awareness: Conversations with the Masters by Anthony de Mello
          • Blue Ocean Strategy: How to Create Uncontested Market Space and Make the Competition Irrelevant by W. Chan Kim and Renée Mauborgne
          • The 4-Hour Body: An Uncommon Guide to Rapid Fat-Loss, Incredible Sex, and Becoming Superhuman by Timothy Ferriss
          • The 4-Hour Chef: The Simple Path to Cooking Like a Pro, Learning Anything, and Living the Good Life by Timothy Ferriss
          • The 4-Hour Workweek: Escape 9-5, Live Anywhere, and Join the New Rich by Timothy Ferriss
          • Getting Past No: Negotiating in Difficult Situations by William Ury
          • Getting to Yes: Negotiating Agreement Without Giving In by Roger Fisher, William Ury, and Bruce Patton
          • The Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance by Mark P. Mattson
          • Introduction to Internal Family Systems by Richard C. Schwartz, PhD
          • Lonely Planet Italian Phrasebook & Dictionary by Pietro Iagnocco, Anna Beltrami, Mirna Cicioni, Karina Coates, and Susie Walker
          • On Writing Well: The Classic Guide to Writing Nonfiction by William Zinsser
          • Secrets of Power Negotiating: Inside Secrets from a Master Negotiator by Roger Dawson
          • Movies & TV Shows
            • Babe
            • Black Mirror
            • The Bourne Identity
            • Die Hard
            • Life Is Beautiful
            • Parks and Recreation
            • Snatch
            • Spirited Away
            • Related Research
              • Bilingualism as a Protection Against the Onset of Symptoms of Dementia | Neuropsychologia
              • Effects of Intermittent Fasting on Health, Aging, and Disease | New England Journal of Medicine
              • Exercise Training Increases Size of Hippocampus and Improves Memory | Proceedings of the National Academy of Sciences
              • Life Extension Factor Klotho Enhances Cognition | Cell Reports
              • The Mitophagy Activator Urolithin A Is Safe and Induces a Molecular Signature of Improved Mitochondrial and Cellular Health in Humans | Nature Metabolism
              • Real-World Effectiveness of a Single-Day Regimen for Transcranial Magnetic Stimulation Using Optimized, Neuroplasticity-Enhanced Techniques in Depression (ONE-D): An Open-Label Case Series | Transcranial Magnetic Stimulation
              • Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression (SAINT) | American Journal of Psychiatry
              • Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry
              • Urolithin A Induces Mitophagy and Prolongs Lifespan in C. elegans and Increases Muscle Function in Rodents | Nature Medicine
              • Relevant Episodes of The Tim Ferriss Show
                • Margaret Atwood — A Living Legend on Creative Process, The Handmaid’s Tale, Resisting Labels, Liminal Beings, Practical Utopias, and More | The Tim Ferriss Show #573
                • Chris Bosh on How to Reinvent Yourself, The Way and The Power, the Poison of Complaining, Leonardo da Vinci, and More | The Tim Ferriss Show #515
                • Famed Explorer Wade Davis — How to Become the Architect of Your Life, Rites of Passage, Optimism as the Purpose of Life, How to Be a Prolific Writer, and More | The Tim Ferriss Show #652
                • Daniel Ek, CEO of Spotify — Habits, Systems and Mental Models for Top Performance | The Tim Ferriss Show #484
                • Forget New Year’s Resolutions and Conduct a ‘Past-Year Review’ Instead | The Tim Ferriss Show #559
                • Elizabeth Gilbert’s Creative Path: Saying No, Trusting Your Intuition, Index Cards, Integrity Checks, Grief, Awe, and Much More | The Tim Ferriss Show #430
                • Jonathan Haidt — The Coddling of the American Mind, How to Become Intellectually Antifragile, and How to Lose Anger by Studying Morality | The Tim Ferriss Show #644
                • Legendary Inventor Danny Hillis (Plus Kevin Kelly) — Unorthodox Lessons from 400+ Patents, Solving the Impossible, Real AI vs. “AI,” Hiring Richard Feynman, Working with Steve Jobs, and More | The Tim Ferriss Show #782
                • Mary Karr — The Master of Memoir on Creative Process and Finding Gifts in the Suffering | The Tim Ferriss Show #479
                • Kevin Kelly — Excellent Advice for Living | The Tim Ferriss Show #669
                • Nick Kokonas and Richard Thaler, Nobel Prize Laureate — Realistic Economics, Avoiding The Winner’s Curse, Using Temptation Bundling, and Going Against the Establishment | The Tim Ferriss Show #830
                • Anne Lamott on Taming Your Inner Critic, Finding Grace, and Prayer | The Tim Ferriss Show #522
                • Elan Lee, Co-Creator of Exploding Kittens — How to Raise Millions on Kickstarter, Deconstructing Mega-Successes, Secrets of Game Design, and The Art of Turning Fans into Superfans | The Tim Ferriss Show #653
                • Tim McGraw — Starting Late with a $20 Guitar, Selling 100M+ Records, and 30+ Years of Creative Longevity | The Tim Ferriss Show #852
                • Frank Miller, Comic Book Legend — Creative Process, The Dark Knight Returns, Sin City, 300, and Much More | The Tim Ferriss Show #831
                • Tish Rabe — 200+ Children’s Books, Getting Picked for Dr. Seuss, Lessons from Early Sesame Street, How to Write 300+ Songs, and More | The Tim Ferriss Show #854
                • Richard Schwartz — IFS, Psychedelic Experiences without Drugs, and Finding Inner Peace for Our Many Parts | The Tim Ferriss Show #492
                • Arnold Schwarzenegger on Psychological Warfare (And Much More) | The Tim Ferriss Show #60
                • Henry Shukman — Zen, Tools for Awakening, Ayahuasca vs. Meditation, Intro to Koans, and Using Wounds as the Doorway | The Tim Ferriss Show #531
                • Derek Sivers — The Joys of an Un-Optimized Life, Finding Paths Less Traveled, Taking Giant Leaps, and Picking the Right “Game of Life” | The Tim Ferriss Show #668
                • How to Be Creative Like a Motherf*cker — Cheryl Strayed | The Tim Ferriss Show #231
                • Master Negotiator William Ury — Proven Strategies and Amazing Stories from Warren Buffett, Nelson Mandela, Kim Jong Un, Hugo Chávez, and More | The Tim Ferriss Show #721
                • Dr. Andrew Weil — The 4-7-8 Breath Method, Cannabis, The Uses of Coca Leaf, Kava for Anxiety, The Psychedelic Renaissance, How to Emerge from Depression, and More | The Tim Ferriss Show #615
                • David Whyte, Poet — Spacious Ease, Irish Koans, Writing in Delirium, and Revelations from a Yak Manger | The Tim Ferriss Show #781
                • Dr. Tommy Wood — How to Future-Proof Your Brain from Dementia | The Tim Ferriss Show #851
                • Steve Young, from Super Bowl MVP to Managing Billions — Hall of Fame 49ers Quarterback on High Performance, Reinvention, Faith, and How to Blend Dreams and Plans | The Tim Ferriss Show #847
                • Health, Science, & Biotech
                  • Ampa Health
                  • Jocasta Neuroscience
                  • Neko Health
                  • Norwegian 4×4 High-Intensity Interval Training
                  • Meditation
                    • Meditation Mondays with Zen Master Henry Shukman | Tim Ferriss
                    • The Way with Henry Shukman
                    • Technology & AI
                      • ChatGPT | OpenAI
                      • Claude | Anthropic
                      • Incogni
                      • Meta
                      • YouTube
                      • Language Learning
                        • Anki
                        • Michel Thomas Method
                        • Spanish Podcast Episodes | Duolingo
                        • SuperMemo
                        • Travel & Finance
                          • CLEAR
                          • Zcash
                          • Personal Improvement
                            • Harvard Negotiation Project
                            • Internal Family Systems (IFS)
                            • Toastmasters
                            • People
                              • Margaret Atwood
                              • Babe
                              • Roberto Benigni
                              • Big Brother
                              • Chris Bosh
                              • Wade Davis
                              • Roger Dawson
                              • Anthony de Mello
                              • Jonathan Downar
                              • Daniel Ek
                              • Liz Gilbert
                              • Jonathan Haidt
                              • Danny Hillis
                              • Mary Karr
                              • Kevin Kelly
                              • Nick Kokonas
                              • Anne Lamott
                              • Elan Lee
                              • Benny Lewis
                              • Mark Mattson
                              • Tim McGraw
                              • Frank Miller
                              • William of Ockham
                              • Tish Rabe
                              • Richard Schwartz
                              • Arnold Schwarzenegger
                              • Dr. Seuss
                              • Henry Shukman
                              • Derek Sivers
                              • Cheryl Strayed
                              • Richard Thaler
                              • Michel Thomas
                              • William Ury
                              • Andrew Weil
                              • David Whyte
                              • Ludwig Wittgenstein
                              • Tommy Wood
                              • Steve Young
                              • William Zinsser
                              • Timestamps
                                • [00:00:00] Start.
                                • [00:00:24] How to go from hyper-optimized to grounded.
                                • [00:03:45] Reinvention in your late 40s: there are more than two options.
                                • [00:07:45] Five meta-skills for the age of AI.
                                • [00:16:06] Post-sabbatical rules that re-focused this podcast.
                                • [00:21:05] Why male friendship is built shoulder-to-shoulder, not face-to-face.
                                • [00:25:04] Love for women authors.
                                • [00:25:24] SAINT, TMS, and Ampa’s one-day brain reset.
                                • [00:27:32] How to build a fanbase by being your authentically weird self.
                                • [00:28:50] My “something is better than nothing” workout routine.
                                • [00:30:33] Staying fit in mind and soul via the past-year review.
                                • [00:31:12] The 4-Hour Body workout routines I still follow.
                                • [00:35:46] Spotting the future titan hiding in an average teen.
                                • [00:37:01] Vacation, burnout, or an outgrown life? Take a mini-retirement.
                                • [00:41:18] Guiding kids through our digital dystopia.
                                • [00:43:45] Does AI kill language learning? What does a new language really give you?
                                • [00:53:36] Muted movies as late-night writing company.
                                • [00:54:13] Best sub-$100 buy: seven seasons of wholesome Pawnee.
                                • [00:55:34] Why two hours of walking fixes almost everything.
                                • [00:57:21] Sleep, unsexily solved: less water, more sun, more exhaustion.
                                • [00:59:16] Privacy as the new luxury in the age of shrinking fame.
                                • [01:02:35] Luxuries worth overspending on: massage, easy travel, and health.
                                • [01:07:24] The best defense against cognitive decline: exercise, exercise, exercise.
                                • [01:11:11] Parting thoughts.
                                • Want to hear another round of me answering your questions? Listen to my previous Q&A episode, in which I covered the coming AI tsunami and how to build an offline advantage, book recommendations, spotting psychedelic red flags, treating courage as a learnable skill, and much more.

                                  This episode is brought to you by Momentous Creatine! I’ve used Momentous Creatine for a long time, as it’s been one of the highest-quality creatine options available. Now, Momentous has taken that quality even further with Signature Spec Creatine, their most advanced version yet. Signature Spec is manufactured in a pharmaceutical facility using reverse-osmosis water purification.  It’s verified through a six-stage testing process with four independent agencies—delivering 10x fewer impurities, 2–5x tighter heavy-metal limits, and added PFAS and microplastics screening. 

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                                  This episode is brought to you by Gusto! If you’re a small business owner looking to simplify payroll and HR tasks, Gusto could be the game-changer you need. Gusto is an all-in-one payroll, benefits, and HR platform designed specifically for small businesses. Gusto automatically files federal, state, and local payroll taxes, handles W-2s and 1099s, and offers straightforward health benefits and 401(k) options for nearly any budget. With an intuitive interface and features like time tracking, onboarding tools, and direct access to certified HR experts, Gusto saves time and eliminates headaches so you can focus on what matters—growing your business. ​As a special offer to listeners, new customers get Gusto free for their first 3 months. This is the perfect time to choose Gusto to take care of your team and stay compliant. See for yourself why 9 out of 10 businesses recommend it. Get started now! Terms apply at Gusto.com/terms.

                                  This episode is brought to you by Wealthfront! Wealthfront is a financial services platform that offers services to help you save and invest your money. Right now, your cash can earn 3.30% APY—that’s the Annual Percentage Yield—with the Wealthfront Cash Account from its network of program banks. That’s 8 times more interest than a typical savings account at a bank, according to FDIC.gov as of 05/18/2026 (Wealthfront’s 3.30% APY vs. 0.38% average savings rate). Right now, for a limited time, Wealthfront is offering new clients that use my sign-up link an additional 0.75% boost over the base rate for three months, meaning you can get up to 4.05% APY, limited to a $150,000 balance. Terms & Conditions apply. Visit Wealthfront.com/Tim to get started. 

                                  The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC (“Wealthfront Brokerage”), member FINRA/SIPC. Wealthfront Brokerage is not a bank. The 3.30% Base APY on cash deposits is as of January 30, 2026, is representative, subject to change, and requires no minimum balance. Wealthfront Brokerage sweeps cash balances to Program Banks, where it earns the variable base APY. The Direct Deposit Plus Investing Program from Wealthfront Advisers LLC and Wealthfront Brokerage LLC provides eligible clients a 0.25% APY increase above the base APY on eligible Cash Account balances (up to an overall boosted rate of 4.30% for a limited time when including the three month 0.75% APY boost for new Cash Account clients) when you direct deposit $1,000/month plus maintain a funded investing account. Wealthfront may change or end the program at any time and determine eligibility at its discretion. Terms and conditions apply. Full details for both promotions at wealthfront.com/promo-terms.

                                  Tim Ferriss, who is not a client, receives cash compensation from Wealthfront Brokerage LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage LLC, which creates an incentive that results in a conflict of interest. Tim expresses his own opinions and Wealthfront does not endorse, sponsor, or promote them. This ad may not reflect the experience of other Cash Account clients, and similar outcomes are not guaranteed. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value. See full disclosures here. 

                                  This episode is brought to you by Helix Sleep! Helix was named best overall mattress of 2026 by Forbes, Wired, and Sleepopolis; best mattress for couples by Oprah Daily; and one of the most trusted brands of 2026 by USA Today. With Helix, there’s a specific mattress to meet each and every body’s unique comfort needs. Just take their quiz—only two minutes to complete—that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They’ll even pick it up from you if you don’t love it. And now, Helix is offering listeners 20% off sitewide for a limited time at HelixSleep.com/Tim.

                                  The post Q&A with Tim — The Art of Male Friendship, Mini-Retirements, Higher-Resolution Living, Reinvention in The Age of AI, and More (#877) appeared first on The Blog of Author Tim Ferriss.

                                  1 hr 16 min
                                • Dr. Andrew Huberman — Peptides, Performance, and Protocols (#876)

                                  Andrew Huberman, Ph.D., (IG: @hubermanlab) is a neuroscientist and tenured professor in the Departments of Neurobiology and Ophthalmology at Stanford University School of Medicine, where he runs the Huberman Lab. His research spans brain development, visual perception and repair from blinding diseases, the neuroscience of stress and resilience, and neural plasticity. He has published more than 75 peer-reviewed articles in top journals including Nature, Science, Cell, and Neuron, and his honors include the Cogan Award, the McKnight Neuroscience Scholar Award, and the Pew Biomedical Scholar Award.

                                  In 2021, he launched the Huberman Lab podcast, which became and remains the most popular health and science podcast in the world. Dr. Huberman is the co-founder of Scicomm Media, the company behind the podcasts Huberman Lab, Perform with Dr. Andy Galpin, and David Senra.

                                  He is the author of Protocols: An Operating Manual for the Human Body.

                                  Please enjoy!

                                  This episode is brought to you by:

                                  • Helix Sleep premium mattresses
                                  • ProLon science-backed Fasting Mimicking Diet that helps activate cellular renewal through fasting, even as you eat nourishing meals
                                  • Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating
                                  • Momentous high-quality creatine for cognitive and muscular support
                                  • Please enjoy!

                                    Listen onSpotify
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                                    Additional podcast platforms

                                    Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                    Transcripts
                                    • This episode
                                    • All episodes
                                    • Show Notes
                                      Connect with Dr. Andrew Huberman

                                      Website | The Huberman Lab Podcast | Twitter | YouTube | Instagram

                                      Dr. Andrew Huberman’s Previous Appearances on The Tim Ferriss Show
                                      • Dr. Andrew Huberman — The Foundations of Physical and Mental Performance, Core Supplements, Sexual Health and Fertility, Sleep Optimization, Psychedelics, and More | The Tim Ferriss Show #660
                                      • Dr. Andrew Huberman — A Neurobiologist on Optimizing Sleep, Enhancing Performance, Reducing Anxiety, Increasing Testosterone, and Using the Body to Control the Mind | The Tim Ferriss Show #521
                                      • Films, Shows, and Books
                                        • Protocols: An Operating Manual for the Human Body by Andrew D. Huberman, Ph.D. | Amazon
                                        • Bad Science: Quacks, Hacks, and Big Pharma Flacks by Ben Goldacre | Amazon
                                        • Bigger, Stronger, Faster* | Prime Video
                                        • The Dark Wizard | Prime Video
                                        • The Eden Project: In Search of the Magical Other by James Hollis | Amazon
                                        • The 4-Hour Body: An Uncommon Guide to Rapid Fat-Loss, Incredible Sex, and Becoming Superhuman by Tim Ferriss | Amazon
                                        • Principles of Neural Science by Eric R. Kandel, John D. Koester, Sarah H. Mack, and Steven A. Siegelbaum | Amazon
                                        • Riding Giants | Prime Video
                                        • Under Saturn’s Shadow: The Wounding and Healing of Men by James Hollis | Amazon
                                        • People
                                          • Canelo Álvarez
                                          • Marc Andreessen
                                          • Abud Bakri
                                          • Martha Beck
                                          • Chris Bell
                                          • Mark Bell
                                          • Hafthór “Thor” Björnsson
                                          • Helen Blau
                                          • Robin Carhart-Harris
                                          • Jeff Cavaliere
                                          • Edward Chang
                                          • Ed Coan
                                          • Paul Conti
                                          • Gül Dölen
                                          • Jonathan Downar
                                          • Dan Gable
                                          • Ben Goldacre
                                          • Jennifer Groh
                                          • Laird Hamilton
                                          • James Hollis
                                          • Alex Honnold
                                          • Shelby Houlihan
                                          • James Schwartz
                                          • Thomas Jessell
                                          • Arthur Jones
                                          • Eric Kandel
                                          • James Magnussen
                                          • Christopher McCurdy
                                          • Mike Mentzer
                                          • Rob Mohr
                                          • Ozzy Osbourne
                                          • Ivan Pavlov
                                          • Dean Potter
                                          • Rick Rubin
                                          • Brad Schoenfeld
                                          • James Schwartz
                                          • Arnold Schwarzenegger
                                          • Andy Stumpf
                                          • Casey Viator
                                          • Matthew Walker
                                          • Nolan Williams
                                          • Dorian Yates
                                          • Training with Dorian Yates
                                            • American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews | Medicine & Science in Sports & Exercise
                                            • Dorian Yates on High Intensity Training, Injury Prevention, and Building Maximum Muscle | The Tim Ferriss Show #235
                                            • Dose-Response Relationship between Weekly Resistance Training Volume and Increases in Muscle Mass: A Systematic Review and Meta-Analysis | Journal of Sports Sciences
                                            • Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men | Journal of Strength and Conditioning Research
                                            • Effects of Resistance Training Performed to Repetition Failure or Non-Failure on Muscular Strength and Hypertrophy: A Systematic Review and Meta-Analysis | Journal of Sport and Health Science
                                            • How Many Times per Week Should a Muscle Be Trained to Maximize Muscle Hypertrophy? A Systematic Review and Meta-Analysis of Studies Examining the Effects of Resistance Training Frequency | Journal of Sports Sciences
                                            • Strength and Hypertrophy Adaptations between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-Analysis | Journal of Strength and Conditioning Research
                                            • Equipment and Protocols
                                              • American-Made Strength Equipment | Rogue Fitness
                                              • AssaultBike Classic | Assault Fitness
                                              • Custom Strength & Exercise Equipment | Sorinex
                                              • Hammer Strength Plate-Loaded Four-Way Neck | Life Fitness
                                              • Jeff Cavaliere: Build Muscle, Great Posture & Resilience to Injury | Huberman Lab
                                              • Pit Shark Belt Squat | Rogue Fitness
                                              • Schwinn AirDyne AD7 | Schwinn Fitness
                                              • Science-Based Workouts & Supplements | ATHLEAN-X
                                              • Psychedelics, Critical Periods, and Neuroplasticity
                                                • Acquisition of Transcend Therapeutics | Otsuka
                                                • Acute Effects of MDMA Co-Administration on the Response to Psilocybin in Healthy Subjects | ClinicalTrials.gov
                                                • Complete Response Letter for Midomafetamine/MDMA | FDA
                                                • Guidance for Psychedelic-Drug Clinical Investigations | FDA
                                                • MAPP2, the Phase 3 Trial of MDMA-Assisted Therapy for PTSD | MAPS
                                                • MDMA-Assisted Therapy for Moderate to Severe PTSD: A Randomized, Placebo-Controlled Phase 3 Trial | Nature Medicine
                                                • Psilocybin and MDMA for PTSD | ClinicalTrials.gov
                                                • Psychedelics Reopen the Social Reward Learning Critical Period | Nature
                                                • Accelerated TMS and D-cycloserine
                                                  • A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial | ClinicalTrials.gov
                                                  • Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial | JAMA Psychiatry
                                                  • Experimental Depression Treatment Is Nearly 80% Effective in Controlled Study | Stanford Medicine
                                                  • Neuroplasticity-Enhanced TMS Therapy | Ampa Health
                                                  • Single-Day Tms Regimens with Pharmacological Augmentation of Plasticity: Five Cases | Transcranial Magnetic Stimulation
                                                  • Cortisol Timing, Light, Exercise, and Sleep
                                                    • The Circadian System Modulates the Cortisol Awakening Response in Humans | Frontiers in Neuroscience
                                                    • The Effects of Post-Awakening Light Exposure on the Cortisol Awakening Response in Healthy Male Individuals | Psychoneuroendocrinology
                                                    • Light Affects Morning Salivary Cortisol in Humans | The Journal of Clinical Endocrinology & Metabolism
                                                    • Transition from Dim to Bright Light in the Morning Induces an Immediate Elevation of Cortisol Levels | The Journal of Clinical Endocrinology & Metabolism
                                                    • Peptides and Metabolic Drugs
                                                      • Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks | U.S. Food and Drug Administration
                                                      • Compounding and the FDA: Questions and Answers | U.S. Food and Drug Administration
                                                      • Effects of Retatrutide on Body Composition in People with Type 2 Diabetes: A Substudy of a Phase 2, Double-Blind, Parallel-Group, Placebo-Controlled, Randomised Trial | The Lancet Diabetes & Endocrinology
                                                      • Egrifta (Tesamorelin for Injection) Prescribing Information | U.S. Food and Drug Administration
                                                      • FDA BPC-157 Briefing Document (2026) | U.S. Food and Drug Administration
                                                      • FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss | U.S. Food and Drug Administration, including retatrutide
                                                      • Mounjaro (Tirzepatide) Prescribing Information | U.S. Food and Drug Administration
                                                      • Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study | Alternative Therapies in Health and Medicine
                                                      • The 2026 Prohibited List | World Anti-Doping Agency
                                                      • Vyleesi (Bremelanotide Injection) Prescribing Information | U.S. Food and Drug Administration
                                                      • What to Know about Retatrutide | Eli Lilly and Company, and the Phase 3 update: Lilly’s Triple Agonist, Retatrutide, Delivered Powerful Weight Loss in Pivotal Phase 3 Obesity Trial | Eli Lilly and Company
                                                      • Sleep, DORAs, Meditation, and Vestibular Stimulation
                                                        • A Method to Soothe and Promote Sleep in Crying Infants Utilizing the Transport Response | Current Biology
                                                        • Effects of Thermal Environment on Sleep and Circadian Rhythm | Journal of Physiological Anthropology
                                                        • Neurofluid Circulation Changes during a Focused Attention Style of Mindfulness Meditation | Proceedings of the National Academy of Sciences
                                                        • Quviviq (Daridorexant) Prescribing Information | U.S. Food and Drug Administration
                                                        • Smart Ring for Sleep & Health | Oura
                                                        • Suvorexant Acutely Decreases Tau Phosphorylation and A? in the Human CNS | Annals of Neurology
                                                        • Unlock Human Performance & Healthspan | WHOOP
                                                        • Whole-Night Continuous Rocking Entrains Spontaneous Neural Oscillations with Benefits for Sleep and Memory | Current Biology
                                                        • Eye-movement sleep mask information | Nocturnal
                                                        • Regenerative Medicine, Cartilage, and Kratom Research
                                                          • Important Patient and Consumer Information About Regenerative Medicine Therapies | U.S. Food and Drug Administration
                                                          • Inhibiting a Master Regulator of Aging Regenerates Joint Cartilage in Mice | Stanford Medicine
                                                          • Kratom Resources | University of Florida College of Pharmacy
                                                          • Long-Wavelength Light, Outdoor Time, and Multilingualism
                                                            • Multilingualism Protects against Accelerated Aging in Cross-Sectional and Longitudinal Analyses of 27 European Countries | Nature Aging
                                                            • Photobiomodulation—Underlying Mechanism and Clinical Applications | Journal of Clinical Medicine
                                                            • Protective Effect of Bilingualism on Aging, MCI, and Dementia: A Community-Based Study | Alzheimer’s & Dementia
                                                            • Review of Light Parameters and Photobiomodulation Efficacy: Dive into Complexity | Journal of Biomedical Optics
                                                            • Time Spent in Outdoor Activities in Relation to Myopia Prevention and Control: A Meta-Analysis and Systematic Review | Acta Ophthalmologica
                                                            • Enhanced Games and Anti-Doping Cases
                                                              • An Olympic Hopeful Blames A Burrito For Her Positive Drug Test | NPR
                                                              • Athletics: Modafinil Is Drug of Choice, Says IAAF Chief | The Independent
                                                              • Australian Swimmer James Magnussen Says He’ll ‘Juice to the Gills’ to Win $1.5m Prize in Enhanced Games | The Guardian
                                                              • Gkolomeev Claims $1M Bonus for 50 Metres Freestyle at Enhanced Games | Reuters
                                                              • Performance-Enhanced Sports Competition | Enhanced Games
                                                              • The Prohibited List | World Anti-Doping Agency
                                                              • Reasoned CAS Award in the Shelby Houlihan Nandrolone Case | Court of Arbitration for Sport
                                                              • Timestamps
                                                                • [00:00:00] Who is Dr. Andrew Huberman?
                                                                • [00:02:03] Dean Potter, The Dark Wizard, and the physics of raw energy.
                                                                • [00:04:11] Why competition destroys performance.
                                                                • [00:05:45] Laird Hamilton, tow-in surfing, and the lure of big waves.
                                                                • [00:06:27] Training with Dorian Yates.
                                                                • [00:18:29] The full weekly split that keeps building strength at 50.
                                                                • [00:21:00] Neck training.
                                                                • [00:25:56] AssaultBike vs. Airdyne.
                                                                • [00:31:12] Revisiting MDMA and psychedelics.
                                                                • [00:48:06] Inducing plasticity is only half the job.
                                                                • [00:53:17] The one-day protocol that cut my anxiety by 90%.
                                                                • [01:00:27] Cortisol as the master key.
                                                                • [01:03:26] Peptides demystified: GLP-1s, growth hormone, and BPC-157.
                                                                • [01:14:44] The Enhanced Games, the Deca burrito, and the honesty problem.
                                                                • [01:17:56] Pinealon, epitalon, and the hunt for more REM sleep.
                                                                • [01:25:02] Why women, not gym bros, are the real peptide market.
                                                                • [01:35:52] Why “no reported side effects” is a trap.
                                                                • [01:43:48] Stem cells, cartilage regrowth, and mining the body for medicine.
                                                                • [01:46:37] AI, wearables, and the race to write to the nervous system.
                                                                • [01:54:12] The MIT mask that puts you to sleep in six minutes.
                                                                • [01:56:09] Inside Andrew’s new operating manual, Protocols.
                                                                • [02:03:30] Navigating grief and remapping loss.
                                                                • [02:04:40] Shut up, suit up, show up.
                                                                • [02:08:03] Parting thoughts.
                                                                • Dr. Andrew Huberman Quotes from the Interview

                                                                  “But what is failure? If somebody really put a gun to your head and said, ‘Curl that bar one more time or I’m going to kill your family,’ you’d curl the bar.”

                                                                  — Dr. Andrew Huberman

                                                                  “Not only am I not going to run for office, I’m running from office.”

                                                                  — Dr. Andrew Huberman

                                                                  “If the anterior mid-cingulate cortex or the posterior insula gets 10% thicker, great. But if you’re not making better decisions, frankly, who gives a shit?”

                                                                  — Dr. Andrew Huberman

                                                                  “There does seem to be something almost spiritual about whether or not we’re funneling energy into things that really reflect us at our best … versus competition. Competition, it turns out, is what destroys people.”

                                                                  — Dr. Andrew Huberman

                                                                  “It’s as if I was dying of thirst and I’m trying to reach for this and I can’t get it. That’s what grief really is.”

                                                                  — Dr. Andrew Huberman

                                                                  Want to hear another episode with someone who built a legendary physique on brutally minimalist training? Listen to my conversation with six-time Mr. Olympia Dorian Yates, in which we discussed high-intensity training and going to failure, his relationship to pain, how he warms up, specific workouts, common mistakes and misconceptions, self-talk, his favorite books, and much more.

                                                                  This episode is brought to you by Momentous Creatine! I’ve used Momentous Creatine for a long time, as it’s been one of the highest-quality creatine options available. Now, Momentous has taken that quality even further with Signature Spec Creatine, their most advanced version yet. Signature Spec is manufactured in a pharmaceutical facility using reverse-osmosis water purification.  It’s verified through a six-stage testing process with four independent agencies—delivering 10x fewer impurities, 2–5x tighter heavy-metal limits, and added PFAS and microplastics screening. 

                                                                  The ultrafine powder also mixes cleanly, with no grit. Creatine supports strength, power, lean muscle, and recovery, with growing research on enhanced memory and cognitive performance. Head to LiveMomentous.com/Tim and use code TIM for 14% off your first one-time order or a total of 35% off your first subscription order.

                                                                  This episode is brought to you by Eight Sleep. Temperature is one of the main causes of poor sleep, and heat is my personal nemesis. But a few years ago, I started using the Pod Cover, and it has transformed my sleep. It fits over your existing mattress and cools or heats each side of the bed independently. I run hot. My lovely partner tends to run cold. With the Pod, we each get the temperature we want. No more fighting over the thermostat.

                                                                  Eight Sleep has launched their newest generation of the Pod: Pod 6, with a temperature-regulating Hub that is fifty percent smaller than Pod 5 and fits under most bed frames. The thermal engine reaches your set temperature twenty percent faster, so the bed is ready when you are. And the cover embeds nine times the biometric sensors—tracking heart rate, HRV, and sleep stages with no wearable. Go to eightsleep.com/Tim and use code TIM to get up to $200 off the Pod for a limited time! Click here to claim this deal and unlock your full potential through optimal sleep.

                                                                  This episode is brought to you buy ProLon! One name that has come up on this podcast more than once is Dr. Valter Longo, a USC professor with decades of peer-reviewed research on fasting, nutrition, and aging. I regularly fast and have done a lot of experiments with fasting over more than a decade, and it has been one of the most incredible unlocks that I have found for both near- and long-term physical and mental health.

                                                                  But fasting can be really hard, and that is why Dr. Longo, best known for the Fasting Mimicking Diet (FMD), developed ProLon. For 5 days, you’re able to get the benefits of fasting—including autophagy, your body’s cellular, self cleanup process—all while eating real, structured, plant-based meals. In scientific studies, 5-day cycles of the Fasting Mimicking Diet improved markers tied to metabolic health and biological aging and helped people drop fat while holding onto lean muscle. And ProLon makes it easy: it comes in one box, everything is clearly laid out, and there’s no guesswork. For a limited time, Prolon is offering my listeners 15% off sitewide, plus a $40 bonus gift when you subscribe to their 5-day program. Just visit ProLonLife.com/Tim.

                                                                  This episode is brought to you by Helix Sleep! Helix was named best overall mattress of 2026 by Forbes, Wired, and Sleepopolis; best mattress for couples by Oprah Daily; and one of the most trusted brands of 2026 by USA Today. With Helix, there’s a specific mattress to meet each and every body’s unique comfort needs. Just take their quiz—only two minutes to complete—that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They’ll even pick it up from you if you don’t love it. And now, Helix is offering listeners 20% off sitewide for a limited time at HelixSleep.com/Tim.

                                                                  The post Dr. Andrew Huberman — Peptides, Performance, and Protocols (#876) appeared first on The Blog of Author Tim Ferriss.

                                                                  2 hr 15 min
                                                                • The Random Show — Tim and Kevin Talk Retreats, Mortality, AI Predictions, Supplements, Rock Climbing at (Almost) 50, and Not Waiting for “Someday” (#875)

                                                                  In this edition of The Random Show, Tim Ferriss and Kevin Rose reunite over tequila to talk Zen retreats, learning to rock climb at (almost) 50, mortality and grief, why you should stop saying “one day,” AI predictions, and much more.

                                                                  This episode is brought to you by:

                                                                  • Incogni, which removes your personal data from the web, helping shield you from fraud, scams, and identity theft
                                                                  • Wealthfront high-yield cash account
                                                                  • Please enjoy!

                                                                    Listen onSpotify
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                                                                    Additional podcast platforms

                                                                    Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                    Transcripts
                                                                    • This episode
                                                                    • All episodes
                                                                    • Show Notes

                                                                      Connect with Kevin Rose:

                                                                      Website | Digg | Diggnation Podcast | Instagram | X | Threads | Bluesky

                                                                      Connect with Tim Ferriss:

                                                                      Website | 5-Bullet Friday | Saisei Foundation | Instagram | X

                                                                      Relevant Tim Ferriss Show Episodes
                                                                      • Assessing Risk and Living Without a Rope – Lessons from Alex Honnold | The Tim Ferriss Show #160
                                                                      • Dr. Adam Gazzaley, UCSF — Brain Optimization and the Future of Psychedelic Medicine | The Tim Ferriss Show #507
                                                                      • Dr. Tommy Wood — How to Future-Proof Your Brain from Dementia | The Tim Ferriss Show #851
                                                                      • Elan Lee, Co-Creator of Exploding Kittens — How to Raise Millions on Kickstarter, Deconstructing Mega-Successes, Secrets of Game Design, The Power of Positive Constraints, The Delights of Craftsmanship, and The Art of Turning Fans into Superfans | The Tim Ferriss Show #653
                                                                      • Henry Shukman — Zen, Tools for Awakening, Ayahuasca vs. Meditation, Intro to Koans, and Using Wounds as the Doorway | The Tim Ferriss Show #531
                                                                      • Matt Mullenweg on Polyphasic Sleep, Tequila, and Building Billion-Dollar Companies | The Tim Ferriss Show #61
                                                                      • Matt Mullenweg — The Art of Crafting a Sabbatical, Tips for Defending Against Hackers, Leveraging Open Source, Thriving in an AI World, and Tips for Life’s Darkest Hours | The Tim Ferriss Show #713
                                                                      • The Maverick of Brain Optimization | The Tim Ferriss Show #83
                                                                      • Michael Pollan — Exploring The New Science of Psychedelics | The Tim Ferriss Show #313
                                                                      • Michael Pollan — This Is Your Mind on Plants | The Tim Ferriss Show #520
                                                                      • My Two-Year Secret Project, COYOTE — The Strategies and Tactics for Building a Bestseller from Nothing with Elan Lee of Exploding Kittens | The Tim Ferriss Show #821
                                                                      • The Random Show, Couch Edition! — Supplements, Hummingbirds, Cock Rings, Optimizing Mitochondria, Breathing and Balance Training, Cool Grip-Strength Tools, and More | The Tim Ferriss Show #858
                                                                      • The Random Show, Rare Drinking Edition — Affordable Luxuries, Brain Stimulation, Sampling the Future (and Some Previews), Recharging with Creative Experiments, Tokenizing Humans with a Bonding Curve, Poetry for People Who Hate Poetry, and Much More | The Tim Ferriss Show #690
                                                                      • Sam Harris, Ph.D. — How to Master Your Mind | The Tim Ferriss Show #342
                                                                      • Tim Ferriss and Matt Mullenweg in Antarctica — Exploring Personal Fears, Bucket Lists, Facing Grief, Crafting Life Missions, and Tim’s Best Penguin Impressions | The Tim Ferriss Show #578
                                                                      • Zen Master Henry Shukman — 20 Minutes of Calm, Plus the Strange and Powerful World of Koans | The Tim Ferriss Show #560
                                                                      • Books & Recommended Reading
                                                                        • 10,000 Years of Dog Domestication | CBC Radio’s Ideas
                                                                        • 360 Feedback Questions: Samples for Managers [With Downloadable Templates] | Indeed
                                                                        • The Blade Itself (The First Law Trilogy, Book One) by Joe Abercrombie | Amazon
                                                                        • The Botany of Desire: A Plant’s-Eye View of the World by Michael Pollan | Amazon
                                                                        • FANG Stocks Explained | Investopedia
                                                                        • Has AI Already Killed Nonfiction? by Tim Ferriss | Tim’s Blog
                                                                        • The Tail End by Tim Urban | Wait But Why
                                                                        • Internet?Enabled Orgasms: How Teledildonics Are Changing the Way We Have Sex | The Conversation
                                                                        • Films & TV
                                                                          • Free Solo | Prime Video
                                                                          • Rain Man | Prime Video
                                                                          • Toy Story | Prime Video
                                                                          • Willy Wonka & The Chocolate Factory | Prime Video
                                                                          • People
                                                                            • Joe Abercrombie
                                                                            • Emil Abrahamsson
                                                                            • Joshua Baer
                                                                            • Sergey Brin
                                                                            • Warren Buffett
                                                                            • Michael Eckert
                                                                            • Molly Ferriss
                                                                            • Adam Gazzaley
                                                                            • Sam Harris
                                                                            • Alex Honnold
                                                                            • Andrew Huberman
                                                                            • Steve Jobs
                                                                            • John Lasseter
                                                                            • Elan Lee
                                                                            • Om Malik
                                                                            • Bill Maris
                                                                            • Terence McKenna
                                                                            • Matt Mullenweg
                                                                            • Elon Musk
                                                                            • Michael Pollan
                                                                            • David Prager
                                                                            • Joe Rogan
                                                                            • Darya Rose
                                                                            • Toaster Rose
                                                                            • Henry Shukman
                                                                            • Lisa Su
                                                                            • Tim Urban
                                                                            • Chris Williamson
                                                                            • Tommy Wood
                                                                            • Yamada Ryoun Roshi
                                                                            • Meditation & Introspection
                                                                              • Four Myths About Zen Buddhism’s Mu Koan by Steven Heine | OUPblog
                                                                              • The Live Your Values Deck | Amazon
                                                                              • Waking Up (Sam Harris’ Mindfulness Meditation App)
                                                                              • The Way (Henry Shukman’s Guided Meditation App)
                                                                              • The Last Time by Sam Harris | Waking Up
                                                                              • The Whole Earth is Medicine by Harry Shukman | Instagram
                                                                              • Supplements, Food, Drinks, & Performance
                                                                                • Bulleit Rye Whiskey
                                                                                • deltaG Ketones
                                                                                • LALO Tequila
                                                                                • Maui Nui Venison
                                                                                • Neutonic Nootropic Toothpicks
                                                                                • Pioneer Pastures A2 Protein (Chocolate / Vanilla | Amazon)
                                                                                • Training
                                                                                  • Abrahangs Protocol (10s on / 50s off, 10 min, 2×/day)
                                                                                  • Ape Index Calculator | 99Boulders
                                                                                  • Learn Chess the Duolingo Way | Duolingo
                                                                                  • M3i Studio Indoor Bike | Keiser
                                                                                  • Norwegian 4×4 High-Intensity Interval Training | On
                                                                                  • The Nug | Frictitious Climbing
                                                                                  • Science & Research
                                                                                    • A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage) | UCSF Neuroscape
                                                                                    • Definium Therapeutics (formerly MindMed)
                                                                                    • Research | Dog Aging Project
                                                                                    • Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder | JAMA
                                                                                    • Tech & AI
                                                                                      • AI Halo | AMD Ryzen
                                                                                      • ChatGPT | OpenAI
                                                                                      • Claude / Claude Code | Anthropic
                                                                                      • Descript
                                                                                      • Ferrite Recording Studio App | Wooji Juice
                                                                                      • Gemini | Google
                                                                                      • Google X
                                                                                      • NVIDIA
                                                                                      • Pixar Animation Studios
                                                                                      • Sennheiser XS Lav USB-C Pro Audio Condenser Microphone | Amazon
                                                                                      • Shokz OpenMeet UC Bone-Conduction Headset | Amazon
                                                                                      • SimCity Games | EA
                                                                                      • SpaceX
                                                                                      • Tesla
                                                                                      • Ubiquiti UniFi G5 Ultra Network Camera | Amazon
                                                                                      • Waymo
                                                                                      • Wispr Flow (Voice-to-Text)
                                                                                      • Timestamps
                                                                                        • [00:00:00] Start.
                                                                                        • [00:00:24] A tequila toast, and getting “taxed” by alcohol as you age.
                                                                                        • [00:02:18] Toaster at 15: a late-night health scare.
                                                                                        • [00:06:01] Losing Om Malik, and finding out on retreat.
                                                                                        • [00:08:03] Matt Mullenweg, Antarctica, and gratitude.
                                                                                        • [00:09:34] Coming to terms with our limited time on Earth.
                                                                                        • [00:14:37] Five days of silence and the koan “Mu.”
                                                                                        • [00:15:20] Kevin’s micro-insight and a plug for The Way.
                                                                                        • [00:27:25] Rock climbing after 40, and a Yosemite goal.
                                                                                        • [00:29:18] Michael Eckert and finger-strength training.
                                                                                        • [00:30:40] The Nug, Abrahangs, and a travel training kit.
                                                                                        • [00:32:57] Free Solo and climbing with a fear of heights.
                                                                                        • [00:37:53] The Blade Itself, and a friend lost in a plane crash.
                                                                                        • [00:39:19] A2 protein and Pioneer Pastures.
                                                                                        • [00:40:34] Maui Nui venison and the nitrate question.
                                                                                        • [00:43:48] deltaG ketones: what they are and the catch.
                                                                                        • [00:45:42] Ketones, dementia, and verbal fluidity.
                                                                                        • [00:46:29] Pre-grieving a parent’s decline.
                                                                                        • [00:48:33] Training not to die: the one bike I can stand and the Norwegian 4×4.
                                                                                        • [00:51:10] Something beats nothing: saunas, treadmills, and Duolingo chess.
                                                                                        • [00:53:04] The MM120 anxiety study — and a small-world surprise.
                                                                                        • [00:56:17] Psilocybin, LSD, and dementia case reports.
                                                                                        • [01:01:28] Neutonic toothpicks and Kevin’s AI-powered home.
                                                                                        • [01:06:12] Spooky AI personalization and investment autopsies.
                                                                                        • [01:17:38] Values cards, contractual bonds, and dark information.
                                                                                        • [01:23:25] 360 reviews and child-rearing.
                                                                                        • [01:24:54] Wispr Flow, Shokz, and my recording rig.
                                                                                        • [01:29:32] The “big three” and where AI goes next.
                                                                                        • [01:44:40] Let your winners run; buy the company, not the product.
                                                                                        • [01:51:08] Digg’s relaunch, 5-Bullet Friday, and parting thoughts.
                                                                                        • Want to hear the last time Kevin and I got together for a Random Show? Listen to our Couch Edition, in which Kevin and I discussed our Zen retreat with Henry Shukman, DIY vagus nerve stimulation, my Bertolotti’s Syndrome back-pain breakthrough, balance boards and slacklining, Emil Abrahamsson’s tendon-strengthening protocol, photobiomodulation and urolithin A for mitochondria, blood-flow-restriction training, the Norwegian 4×4 protocol, vintage Japanese finds on Etsy, Kevin’s hummingbird-feeder obsession, and much more.

                                                                                          This episode is brought to you by Wealthfront! Wealthfront is a financial services platform that offers services to help you save and invest your money. Right now, your cash can earn 3.30% APY—that’s the Annual Percentage Yield—with the Wealthfront Cash Account from its network of program banks. That’s 8 times more interest than a typical savings account at a bank, according to FDIC.gov as of 05/18/2026 (Wealthfront’s 3.30% APY vs. 0.38% average savings rate). Right now, for a limited time, Wealthfront is offering new clients that use my sign-up link an additional 0.75% boost over the base rate for three months, meaning you can get up to 4.05% APY, limited to a $150,000 balance. Terms & Conditions apply. Visit Wealthfront.com/Tim to get started. 

                                                                                          The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC (“Wealthfront Brokerage”), member FINRA/SIPC. Wealthfront Brokerage is not a bank. The 3.30% Base APY on cash deposits is as of January 30, 2026, is representative, subject to change, and requires no minimum balance. Wealthfront Brokerage sweeps cash balances to Program Banks, where it earns the variable base APY. The Direct Deposit Plus Investing Program from Wealthfront Advisers LLC and Wealthfront Brokerage LLC provides eligible clients a 0.25% APY increase above the base APY on eligible Cash Account balances (up to an overall boosted rate of 4.30% for a limited time when including the three month 0.75% APY boost for new Cash Account clients) when you direct deposit $1,000/month plus maintain a funded investing account. Wealthfront may change or end the program at any time and determine eligibility at its discretion. Terms and conditions apply. Full details for both promotions at wealthfront.com/promo-terms.

                                                                                          Tim Ferriss, who is not a client, receives cash compensation from Wealthfront Brokerage LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage LLC, which creates an incentive that results in a conflict of interest. Tim expresses his own opinions and Wealthfront does not endorse, sponsor, or promote them. This ad may not reflect the experience of other Cash Account clients, and similar outcomes are not guaranteed. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value. See full disclosures here. 

                                                                                          This episode is brought to you by Incogni: erase your personal data from the web and prevent scams, fraud, and identity theft! Incogni automatically removes your information across 420+ data brokers (1,000+ additional sites covered in their Unlimited plan), and they keep it scrubbed automatically. Deloitte has independently verified the headline numbers (245M+ removal requests), and the company adheres to AICPA SOC security standards, with an A+ rating from the BBB. And with their Unlimited plan, if you find your info on a site they don’t automatically monitor, just send them the link, and their privacy team will handle it. ​Protect yourself now with Incogni. Go to Incogni.com/Tim to get 60% off their annual plan.

                                                                                          DISCLAIMER FROM TIM FERRISS: I am not an investment adviser. Nor is Kevin Rose. All opinions are mine alone. Or his. There are risks involved in placing any investment in securities or in Bitcoin or in cryptocurrencies or in anything. None of the information presented herein is intended to form the basis of any offer or recommendation or have any regard to the investment objectives, financial situation, or needs of any specific person, and that includes you, my dear listener or reader. Everything you’re going to hear is for informational entertainment purposes only.

                                                                                          The post The Random Show — Tim and Kevin Talk Retreats, Mortality, AI Predictions, Supplements, Rock Climbing at (Almost) 50, and Not Waiting for “Someday” (#875) appeared first on The Blog of Author Tim Ferriss.

                                                                                          1 hr 58 min
                                                                                        • Guy Oseary — The Legendary Hollywood Power Broker on 5-Minute Decisions, 36 Years of Managing Madonna, 26 IPOs, and Spotting Magic First (#874)

                                                                                          Guy Oseary (@guyoseary) has been spotting talent before anyone else could see it for nearly four decades. Under his leadership at Maverick Records, Maverick sold more than 100 million albums. Guy has managed some of the biggest names in music, including Madonna, the Red Hot Chili Peppers, and U2, and was named Variety‘s Music Mogul of the Year in 2022. He executive produced Twilight, which became one of the most successful franchises in movie history, generating more than $3.5B.  

                                                                                          Guy was also an early investor in Vita Coco and co-founded A-Grade Investments and then Sound Ventures, now with nearly $2 billion under management. At A-Grade, his hits included Airbnb, Uber, and Spotify. Sound Ventures launched with less than $100M and has since had 86 exits and 26 IPOs.

                                                                                          Please enjoy!

                                                                                          This episode is brought to you by:

                                                                                          • Momentous high-quality creatine for cognitive and muscular support
                                                                                          • AG1 all-in-one nutritional supplement
                                                                                          • Listen onSpotify
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                                                                                            Guy Oseary — The Legendary Hollywood Power Broker on 5-Minute Decisions, 36 Years of Managing Madonna, 26 IPOs, and Spotting Magic First<iframe src="https://www.art19.com/shows/58dacbdc-646e-4585-9914-19c3de11d1ba/episodes/5ddf31c4-0f63-4bf2-acc5-0bcdb8c643e3/embed?type=micro" style="width: 100%; height: 30px; border: 0 none;" scrolling="no"></iframe>
                                                                                            Additional podcast platforms

                                                                                            Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                                            Transcripts
                                                                                            • This episode
                                                                                            • All episodes
                                                                                            • Show Notes
                                                                                              • Connect with Guy Oseary:
                                                                                              • Instagram | Facebook | X

                                                                                                Books & Recommended Reading
                                                                                                • Chris Rock, Matthew McConaughey, and Woody Harrelson Direct and Star in This Exclusive Guy Oseary Tribute by Zack Sharf | Variety
                                                                                                • Not Bad for a Kid by Robert Hilburn | Los Angeles Times
                                                                                                • From Maverick to Mogul, Madonna’s Manager Guy Oseary Transcends the Music World to Take on NFTs by Shirley Halperin | Variety
                                                                                                • Where Did I Go Right?: You’re No One in Hollywood Unless Someone Wants You Dead by Bernie Brillstein
                                                                                                • Music
                                                                                                  • Candlebox by Candlebox
                                                                                                  • Come to Daddy by Aphex Twin
                                                                                                  • Confessions on a Dance Floor by Madonna
                                                                                                  • Fat of the Land by Prodigy
                                                                                                  • Frozen by Madonna
                                                                                                  • Jagged Little Pill by Alanis Morissette
                                                                                                  • Music by Madonna
                                                                                                  • Perfect by Alanis Morissette
                                                                                                  • Purple Rain by Prince
                                                                                                  • Ray of Light by Madonna
                                                                                                  • Thriller by Michael Jackson
                                                                                                  • Teenage Whore by Hole
                                                                                                  • You Oughta Know by Alanis Morissette
                                                                                                  • Films & TV
                                                                                                    • Beverly Hills, 90210
                                                                                                    • Percy Jackson & the Olympians: The Lightning Thief
                                                                                                    • SNL
                                                                                                    • Twilight
                                                                                                    • People & Bands
                                                                                                      • Michelle Alves
                                                                                                      • Dan Aykroyd
                                                                                                      • Jonas Åkerlund
                                                                                                      • Sam Altman
                                                                                                      • Dario Amodei
                                                                                                      • Aphex Twin
                                                                                                      • Glen Ballard
                                                                                                      • Jim Balsillie
                                                                                                      • John Belushi
                                                                                                      • Marc Benioff
                                                                                                      • Bernie Brillstein
                                                                                                      • Candlebox
                                                                                                      • Rosemary Carroll
                                                                                                      • Santa Claus
                                                                                                      • Kurt Cobain
                                                                                                      • Chris Cunningham
                                                                                                      • Sky Dayton
                                                                                                      • Freddy DeMann
                                                                                                      • Neysa DeMann
                                                                                                      • Pilar DeMann
                                                                                                      • Paul Drews
                                                                                                      • Daniel Ek
                                                                                                      • Effie Epstein
                                                                                                      • Evil E
                                                                                                      • Shawn Fanning
                                                                                                      • Flea
                                                                                                      • John Frusciante
                                                                                                      • Michael Goldstone
                                                                                                      • Bill Gross
                                                                                                      • Woody Harrelson
                                                                                                      • Hen Gee
                                                                                                      • Hole
                                                                                                      • Michael Hutchence
                                                                                                      • Ice-T
                                                                                                      • Billy Idol
                                                                                                      • INXS
                                                                                                      • Anthony Kiedis
                                                                                                      • Neerav Kingsland
                                                                                                      • Mike Kirban
                                                                                                      • Jack Kornfield
                                                                                                      • Dave Koskoff
                                                                                                      • Nick Koskoff
                                                                                                      • Josh Kushner
                                                                                                      • Ashton Kutcher
                                                                                                      • L.A. Dream Team
                                                                                                      • Courtney Love
                                                                                                      • Madonna
                                                                                                      • Kevin Martin
                                                                                                      • Matthew McConaughey
                                                                                                      • Mirwais
                                                                                                      • Joni Mitchell
                                                                                                      • Demi Moore
                                                                                                      • Mark Morgan
                                                                                                      • Alanis Morissette
                                                                                                      • Morrissey
                                                                                                      • Muse
                                                                                                      • Elon Musk
                                                                                                      • Nirvana
                                                                                                      • William Orbit
                                                                                                      • Sean Parker
                                                                                                      • Prince
                                                                                                      • The Prodigy
                                                                                                      • Rage Against the Machine
                                                                                                      • Red Hot Chili Peppers
                                                                                                      • Sex Pistols
                                                                                                      • Steve Rifkind
                                                                                                      • Johnny Rivers
                                                                                                      • Chris Rock
                                                                                                      • Seth Rodsky
                                                                                                      • Stéphane Sednaoui
                                                                                                      • Garry Shandling
                                                                                                      • Mikey Shulman
                                                                                                      • Chad Smith
                                                                                                      • John Somorjai
                                                                                                      • U2
                                                                                                      • Reese Witherspoon
                                                                                                      • Companies & Organizations
                                                                                                        • Airbnb
                                                                                                        • Anthropic
                                                                                                        • Beverly Hills High School
                                                                                                        • Brillstein Entertainment Partners
                                                                                                        • Club Lingerie
                                                                                                        • EarthLink
                                                                                                        • Epic Records
                                                                                                        • Fred Segal
                                                                                                        • Geffen Records (DGC)
                                                                                                        • Idealab
                                                                                                        • KDAY
                                                                                                        • KROQ
                                                                                                        • Le Parc at Melrose
                                                                                                        • Maverick Entertainment Group
                                                                                                        • Maverick Management
                                                                                                        • MTV
                                                                                                        • Napster
                                                                                                        • OpenAI
                                                                                                        • Research In Motion / BlackBerry
                                                                                                        • Rhyme Syndicate
                                                                                                        • Salesforce Ventures
                                                                                                        • Sound Ventures
                                                                                                        • SpaceX
                                                                                                        • Spotify
                                                                                                        • Suno
                                                                                                        • Thrive Capital
                                                                                                        • Uber
                                                                                                        • The Vita Coco Company
                                                                                                        • Vitaminwater (Glacéau)
                                                                                                        • Wise Guy Prods
                                                                                                        • Tools & Apps
                                                                                                          • ChatGPT (OpenAI)
                                                                                                          • Claude (Anthropic)
                                                                                                          • Grok (xAI)
                                                                                                          • X (Twitter)
                                                                                                          • Timestamps
                                                                                                            • [00:00:00] Start.
                                                                                                            • [00:02:01] How a West Hollywood balcony became a backstage pass.
                                                                                                            • [00:03:51] A knife on Pico Boulevard and the snap decision to switch schools.
                                                                                                            • [00:05:54] Faking a Beverly Hills address to get inside another world.
                                                                                                            • [00:08:10] Wise Guy Records: a 15-year-old builds a portfolio out of nothing.
                                                                                                            • [00:10:09] Guy’s alternative terms when Bernie Brillstein offered $25,000.
                                                                                                            • [00:11:34] The one moment that confirmed Guy was on the right path.
                                                                                                            • [00:12:29] Freddy DeMann enters the picture and Guy proves himself with Ice-T’s crew.
                                                                                                            • [00:15:07] A desk at Maverick Records in exchange for no salary.
                                                                                                            • [00:17:08] Chasing Hole and Rage Against the Machine — and losing both.
                                                                                                            • [00:23:34] Candlebox in five minutes: seeing thousands in a room of 30.
                                                                                                            • [00:24:11] Why “magic” beats everything else.
                                                                                                            • [00:26:37] Signing Alanis off a single song, and stopping Muse mid-audition.
                                                                                                            • [00:31:59] The real Alanis story: “Perfect,” Joni Mitchell, and a 30-million-selling debut.
                                                                                                            • [00:35:24] What Madonna taught Guy about thinking without walls.
                                                                                                            • [00:38:50] From bands to Twilight: the power of a blank canvas.
                                                                                                            • [00:45:30] How Guy got into investing, and the IdeaLab bet that wiped him out before the crash.
                                                                                                            • [00:54:31] Why Guy is known as a great curator of people.
                                                                                                            • [00:58:32] The three-month window that caught OpenAI and Anthropic.
                                                                                                            • [01:06:07] AI music and the battle to ensure human musicians get paid.
                                                                                                            • [01:09:30] How Spotify solved the problems Napster couldn’t overcome.
                                                                                                            • [01:14:50] SpaceX and Bitcoin: the ones that got away.
                                                                                                            • [01:17:32] The rewards, rigors, and responsibilities of back-to-back touring.
                                                                                                            • [01:21:44] Why Guy never stops to celebrate.
                                                                                                            • [01:24:45] Splitting with Ashton Kutcher after 20 years.
                                                                                                            • [01:27:30] Final thoughts on Guy’s first podcast.
                                                                                                            • Guy Oseary Quotes from the Interview

                                                                                                              “Sometimes having no options and no choice is really the best option.”

                                                                                                              — Guy Oseary

                                                                                                              “It always starts with the magic. I don’t care if you’re a tech company or whatever it is—a film, a product, a book—magic. You’ve got to have magic. Something has to pull you in.”

                                                                                                              — Guy Oseary

                                                                                                              “In my mind, every founder I invest in, I look at them like they are the rock star. I go, ‘That person has music they want to share with the world.'”

                                                                                                              — Guy Oseary

                                                                                                              “Fair use is not fair.”

                                                                                                              — Guy Oseary

                                                                                                              “I don’t feel accomplished. I don’t feel at all. I feel like I still have so much to prove and so much to do.”

                                                                                                              — Guy Oseary

                                                                                                              Want to hear another episode with someone who has a preternatural gift for spotting world-class talent? Listen to my most recent conversation with legendary music producer Rick Rubin, in which we discussed timeless methods for unlocking creativity, secrets hidden in plain sight, the future with AI, working with strong personalities, breaking out of “the sameness,” reinvention versus going narrow, and much more.

                                                                                                              This episode is brought to you by AG1. I’ve taken AG1 for more than a decade. Longtime listeners have heard me call it my nutritional insurance. Here’s the news: they recently launched AG1 Pro, designed for people focused on performance and longevity. I’ll be traveling soon, and I’m throwing this in my bag to cover my bases while I travel. Past a certain age, maintaining lean muscle becomes priority number one, and AG1 Pro is formulated to support exactly that. It includes HMB, a clinically studied compound that supports protein synthesis and helps reduce protein breakdown, plus zinc carnosine to support the gut lining. Remember: training is only half the equation. Recovery is where the work compounds, and AG1 Pro is built to support it. It’s NSF Certified for Sport, so what’s on the label is what’s in the pouch. Get your free AG1 Pro Yeti Shaker in the Welcome Kit at Drinkag1.com/Tim.

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                                                                                                              The post Guy Oseary — The Legendary Hollywood Power Broker on 5-Minute Decisions, 36 Years of Managing Madonna, 26 IPOs, and Spotting Magic First (#874) appeared first on The Blog of Author Tim Ferriss.

                                                                                                              1 hr 33 min
                                                                                                            • The “Divine Leaf” with 8,000+ Years of Use — Exploring the Many Benefits of Coca with Dr. Andrew Weil and Wade Davis (#871)

                                                                                                              “Coca is to cocaine what potatoes are to vodka”

                                                                                                              — Wade Davis with Dr. Andrew Weil on the health benefits, sacred history, and unjust prohibition of the most misunderstood plant on Earth

                                                                                                              Dr. Andrew Weil (@DrWeil) is a pioneer in integrative medicine and founder of the Andrew Weil Center for Integrative Medicine at the University of Arizona, where he holds the Lovell-Jones Endowed Chair and serves as Clinical Professor of Medicine and Professor of Public Health.

                                                                                                              Wade Davis (@wadedavisofficial) is an ethnographer, writer, photographer, and filmmaker. From 2014 to 2024 he served as Professor of Anthropology and BC Leadership Chair in Cultures and Ecosystems at Risk at the University of British Columbia, and from 2000 to 2013 as Explorer-in-Residence at the National Geographic Society.

                                                                                                              Connect with the Beneficial Plant Research Association (BPRA): 

                                                                                                              • Website (scroll down to donate)
                                                                                                              • Coca Leaf Research
                                                                                                              • Coca Leaf Documentary
                                                                                                              • Coca Leaf Retreat
                                                                                                              • Please enjoy!

                                                                                                                This episode is brought to you by:

                                                                                                                • Incogni — which removes your personal data from the web, helping shield you from fraud, scams, and identity theft
                                                                                                                • Maui Nui Venison​ — delicious, nutrient-dense, and responsible red meat
                                                                                                                • 5-Bullet Friday — my very own, free email newsletter
                                                                                                                • Listen onSpotify
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                                                                                                                  Additional podcast platforms

                                                                                                                  Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                                                                  Transcripts
                                                                                                                  • This episode
                                                                                                                  • All episodes
                                                                                                                  • Show Notes
                                                                                                                    • Connect with Dr. Andrew Weil:
                                                                                                                    • Website | X | Instagram | Facebook

                                                                                                                      • Connect with Wade Davis:
                                                                                                                      • Website | X | Instagram | Facebook

                                                                                                                        • Connect with the Beneficial Plant Research Association (BPRA):
                                                                                                                        • Website | Coca Leaf Research | Coca Leaf Documentary | Coca Leaf Retreat

                                                                                                                          Previous Guest Appearances
                                                                                                                          • Dr. Andrew Weil — Optimal Health, Plant Medicine, and More | The Tim Ferriss Show #350
                                                                                                                          • Dr. Andrew Weil — The 4-7-8 Breath Method, Cannabis, The Uses of Coca Leaf, Rehabilitating Demonized Plants, Kava for Anxiety, Lessons from Wade Davis, The Psychedelic Renaissance, How to Emerge from Depression, Tales from 50+ Visits to Japan, Matcha Benefits, and More | The Tim Ferriss Show #615
                                                                                                                          • Famed Explorer Wade Davis — How to Become the Architect of Your Life, The Divine Leaf of Immortality, Rites of Passage, Voodoo Demystified, Optimism as the Purpose of Life, How to Be a Prolific Writer, Psychedelics, Monetizing the Creativity of Your Life, and More | The Tim Ferriss Show #652
                                                                                                                          • Books & Films
                                                                                                                            • One River: Explorations and Discoveries in the Amazon Rain Forest by Wade Davis
                                                                                                                            • The Hold Life Has: Coca and Cultural Identity in an Andean Community by Catherine J. Allen
                                                                                                                            • Reefer Madness
                                                                                                                            • Light at the Edge of the World by Wade Davis
                                                                                                                            • Articles, Research, & Relevant Resources
                                                                                                                              • The New Politics of Coca by Andrew Weil | The New Yorker
                                                                                                                              • The Secret History of Coca by Wade Davis | Rolling Stone
                                                                                                                              • The Therapeutic Value of Coca in Contemporary Medicine by Andrew T. Weil | Journal of Ethnopharmacology
                                                                                                                              • Coca: High Altitude Remedy of the Ancient Incas | Wilderness & Environmental Medicine
                                                                                                                              • Does Chewing Coca Leaves Influence Physiology at High Altitude? | Indian Journal of Clinical Biochemistry
                                                                                                                              • Coca: The History and Medical Significance of an Ancient Andean Tradition | US National Library of Medicine
                                                                                                                              • Beta-Carotene and Smoking: Can the Combination Cause Cancer? | Healthline
                                                                                                                              • Nutritional Value of Coca by James A. Duke, David Aulik, and Timothy Plowman | Biodiversity Heritage Library
                                                                                                                              • Rooted in Colonialism, Coca Prohibition Could Be Nearing Its End | Filter
                                                                                                                              • Coca Chronicles: Bolivia Challenges UN Coca Leaf Ban | Washington Office on Latin America
                                                                                                                              • Report of the Commission of Enquiry on the Coca Leaf | UN Social and Economic Council (ECOSOC)
                                                                                                                              • Fact Sheet: Coca Leaf and the UN Drugs Conventions | Transnational Institute
                                                                                                                              • Coca Yes, Cocaine No? | Transnational Institute
                                                                                                                              • Coca Myths | Transnational Institute
                                                                                                                              • Observations on the Effects of Cuca, or Coca, the Leaves of Erythroxylon Coca by Robert Christison | The British Medical Journal (1876)
                                                                                                                              • Travel Medicine, Coca and Cocaine: Demystifying and Rehabilitating Erythroxylum | Tropical Diseases, Travel Medicine, and Vaccines
                                                                                                                              • My Favorite “Smart Drugs” | Tim Ferriss
                                                                                                                              • Colombia: Potential Cocaine Production Increased by 53 Per Cent in 2023 | UN Office on Drugs and Crime
                                                                                                                              • The Origins of Coca: Museum Genomics Reveals Multiple Independent Domestications from Progenitor Erythroxylum Gracilipes | Systematic Biology
                                                                                                                              • Drug Scheduling | US Drug Enforcement Administration
                                                                                                                              • A Return to the Village: Community Ethnographies and the Study of Andean Culture in Retrospective edited by Francisco Ferreira with Billie Jean Isbell | University of London
                                                                                                                              • Where They Sing to the River: Sierra Nevada, the Heart of the World by Wade Davis | Literary Hub
                                                                                                                              • Coca Chronicles: Monitoring the UN Coca Review | Transnational Institute
                                                                                                                              • Cutting Sugar in Drinks with ‘The Most Illicit Plant in the World’ | FoodNavigator
                                                                                                                              • Psilocybin Proves Promising Treatment for Cocaine Use Disorder, According to UAB Study | UAB News
                                                                                                                              • Dr. Nora Volkow — Director of the National Institute on Drug Abuse (NIDA) | The Tim Ferriss Show #673
                                                                                                                              • RFK Jr. Launches Plan to Curb “Overprescribing” of Psychiatric Drugs | CNN
                                                                                                                              • Philadelphia CBP Discovers “Green” Cocaine in Shipment from Colombia | US Customs and Border Protection
                                                                                                                              • Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies | JAMA
                                                                                                                              • The Annual Running of the Boundaries (from Light at the Edge of the World by Wade Davis) | Playtime
                                                                                                                              • Mycophobia: The Fear of Mushrooms Reinterpreted | North Spore
                                                                                                                              • Argentina Has a Powerful Secret Weapon in the World Cup Final by Wade Davis | Rolling Stone
                                                                                                                              • Observations on the Effects of Cuca, or Coca, the Leaves of Erythroxylon Coca by Robert Christison | The British Medical Journal
                                                                                                                              • The Weird (and Wired) Truth Behind What’s Really in Coca-Cola by Claudia Geib | Eater
                                                                                                                              • People
                                                                                                                                • Catherine J. Allen
                                                                                                                                • Harry Anslinger
                                                                                                                                • James A. Duke
                                                                                                                                • Howard B. Fonda
                                                                                                                                • Joseph Goebbels
                                                                                                                                • Hermann Göring
                                                                                                                                • Peter Hendricks
                                                                                                                                • Robert F. Kennedy Jr.
                                                                                                                                • Christopher McCurdy
                                                                                                                                • Eliot Ness
                                                                                                                                • Timothy Plowman
                                                                                                                                • Richard Evans Schultes
                                                                                                                                • Nora Volkow
                                                                                                                                • P.O. Wolff
                                                                                                                                • Organizations & Institutions
                                                                                                                                  • Andrew Weil Center for Integrative Medicine at University of Arizona
                                                                                                                                  • Beneficial Plant Research Association (BPRA) / The Coca Project
                                                                                                                                  • University of Florida College of Pharmacy
                                                                                                                                  • US Food and Drug Administration (FDA)
                                                                                                                                  • Harvard University Herbaria and Botanical Museum
                                                                                                                                  • National Institute on Drug Abuse (NIDA)
                                                                                                                                  • World Health Organization (WHO)
                                                                                                                                  • Companies & Products
                                                                                                                                    • Coca-Cola
                                                                                                                                    • Matcha Kari
                                                                                                                                    • 7 Up
                                                                                                                                    • Stepan Company
                                                                                                                                    • True Food Kitchen
                                                                                                                                    • Substances, Compounds, & Concepts
                                                                                                                                      • Adderall (Amphetamine)
                                                                                                                                      • Atropine
                                                                                                                                      • Beta-Carotene
                                                                                                                                      • Coca (Erythroxylum Coca / E. Novogranatense)
                                                                                                                                      • Cocaine
                                                                                                                                      • Controlled Substances Act
                                                                                                                                      • Diamox (Acetazolamide)
                                                                                                                                      • Kola Nut
                                                                                                                                      • Kratom
                                                                                                                                      • Mambe
                                                                                                                                      • Modafinil
                                                                                                                                      • Prozac (Fluoxetine)
                                                                                                                                      • Psilocybin
                                                                                                                                      • Ritalin (Methylphenidate)
                                                                                                                                      • Scopolamine
                                                                                                                                      • Single Convention on Narcotic Drugs (1961)
                                                                                                                                      • Timestamps
                                                                                                                                        • [00:00:00] Start.
                                                                                                                                        • [00:02:38] When coca tea cured my brutal altitude sickness in Chile.
                                                                                                                                        • [00:04:01] Andy meets coca, 1965: the Andes’ master medicine for gut, energy, mood, metabolism.
                                                                                                                                        • [00:06:20] 14 alkaloids, one scapegoat.
                                                                                                                                        • [00:07:11] The paradox: one remedy for both diarrhea and constipation.
                                                                                                                                        • [00:11:37] 8,000 years, zero addiction — and the 1975 study no one wanted to run.
                                                                                                                                        • [00:13:11] Eradication began 60 years before there was a cocaine problem.
                                                                                                                                        • [00:16:27] Two nations inside Peru: alcohol versus coca.
                                                                                                                                        • [00:17:05] The 1950 UN commission that dictated coca policy by pseudoscience, fear, and racism.
                                                                                                                                        • [00:18:10] Filed beside fentanyl and heroin; 250,000 families and the price of peace.
                                                                                                                                        • [00:20:03] What coca actually feels like: milder than half a coffee, no crash, no withdrawal.
                                                                                                                                        • [00:24:19] Decoupling the leaf from the cartels; why crop substitution is a fantasy.
                                                                                                                                        • [00:25:54] Domesticated three times; the accident of Schedule II.
                                                                                                                                        • [00:27:49] The sacred leaf: k’intu, cruceta, Pachamama, runakuna.
                                                                                                                                        • [00:31:11] Hayo in the Sierra Nevada, and Latin America’s most-denied gift.
                                                                                                                                        • [00:32:53] The wedge in the door: demand, the FDA, and an entrepreneur’s gold mine.
                                                                                                                                        • [00:40:22] The story coca deserves — a film, green powders, and one good study.
                                                                                                                                        • [00:43:12] Monkey mind, the tax of consciousness, and an 84th birthday on coca.
                                                                                                                                        • [00:47:35] Who to fund: McCurdy and the hunt for legal leaves.
                                                                                                                                        • [00:49:17] Could coca treat cocaine addiction? Cost, and NIDA’s timing.
                                                                                                                                        • [00:53:18] “Green cocaine” at the airport: coca is to cocaine as potatoes are to vodka.
                                                                                                                                        • [00:56:58] A 24-hour ritual run powered entirely by coca.
                                                                                                                                        • [00:59:07] Why two men gave their careers to one leaf — and the pharmaceutical body count.
                                                                                                                                        • [01:06:22] America’s legal cocaine capital, and Coke’s secret recipe.
                                                                                                                                        • [01:09:08] No accident: the hideous prose behind laws we still obey.
                                                                                                                                        • [01:15:42] Parting thoughts.
                                                                                                                                        • Quotes from the Interview

                                                                                                                                          “If I told you there was a plant that you could take that gave you a slight lightness of being, a slight kind of skip in your step, a sense of well-being that eliminated all these sort of existential little neuroses that we all suffer as conscious beings, and it allowed you to focus at task, whatever that creative task was, whether it was a spinning of wool or the writing of digital code, and you could sit at task all day long concentrating on task with immense focus, with no sense of being under the influence of any plant, nothing as harsh as a second cup of coffee, and you found yourself at the end of the day ready to go home, have dinner, and do it all over again the next day—the truth is that coca has this capacity to improve our lives.”

                                                                                                                                          — Wade Davis

                                                                                                                                          “[Coca is] as important to that [Indigenous Andes] population as peppermint and chamomile are in European medicine. It’s their major medicinal plant.”

                                                                                                                                          — Andrew Weil

                                                                                                                                          “Coca has been used in South America by virtually every culture of the Andean and Northwest Amazon for 8,000 years. And during that time, there’s been no evidence whatsoever of any toxicity, let alone addiction.”

                                                                                                                                          — Wade Davis

                                                                                                                                          “In coca, there are 14 alkaloids. Cocaine is one of them. They all have similar chemical structures, and none of them have ever been studied. Once we isolated cocaine from the leaf, everybody lost interest in everything else.”

                                                                                                                                          — Andrew Weil

                                                                                                                                          “Coca is to cocaine what potatoes are to vodka.”

                                                                                                                                          — Wade Davis

                                                                                                                                          “As the anthropologist Catherine Allen said, to deny people coca in the Andes is not like denying the Germans beer or the British tea or the French coffee. It’s actually an act of cultural genocide because you cannot be runakuna, you cannot be of the Andes, of Pachamama, if you do not use the leaves.”

                                                                                                                                          — Wade Davis

                                                                                                                                          “I think that coca is the most perfect example of how we’ve gone wrong in our relations with the natural world, really failing to see that plant for what it is, confusing it with this one component of it, and then getting ourselves in enormous amounts of trouble.”

                                                                                                                                          — Andrew Weil

                                                                                                                                          “I feel that liberating coca is the final act of my professional life. I feel that very sincerely.”

                                                                                                                                          — Wade Davis

                                                                                                                                          Want to hear another episode that untangles the curse from the blessing of coca? Listen to this one with ethnobotanist Dr. Mark Plotkin about the 8,000-year history of the coca leaf, the varieties of coca and their uses, coca-leaf bonding among the Kogis of Northern Colombia, surviving altitude sickness in the Andes, the adventures of Richard Evans Schultes, ayahuasca and shamanic knowledge, the biocultural conservation of the rainforest, and much more.

                                                                                                                                          This episode is brought to you by Incogni: erase your personal data from the web and prevent scams, fraud, and identity theft! Incogni automatically removes your information across 420+ data brokers (1,000+ additional sites covered in their Unlimited plan), and they keep it scrubbed automatically. Deloitte has independently verified the headline numbers (245M+ removal requests), and the company adheres to AICPA SOC security standards, with an A+ rating from the BBB. And with their Unlimited plan, if you find your info on a site they don’t automatically monitor, just send them the link, and their privacy team will handle it. ​Protect yourself now with Incogni. Go to Incogni.com/Tim to get 60% off their annual plan.

                                                                                                                                          This episode is also brought to you by Maui Nui Venison. I’ve been eating ​Maui Nui Venison​ for more than five years, and I eat it practically every week. It’s the cleanest and most nutrient-dense red meat you can buy.

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                                                                                                                                          The post The “Divine Leaf” with 8,000+ Years of Use — Exploring the Many Benefits of Coca with Dr. Andrew Weil and Wade Davis (#871) appeared first on The Blog of Author Tim Ferriss.

                                                                                                                                          1 hr 23 min
                                                                                                                                        • Sebastian Mallaby, Biographer of Demis Hassabis — Lessons from 100+ AI Insiders on The Race to Superintelligence, The Religion of AI, and Spotting Breakthroughs Early (#870)

                                                                                                                                          Sebastian Mallaby (@scmallaby) is the Paul A. Volcker senior fellow for international economics at the Council on Foreign Relations, a two-time Pulitzer Prize finalist, and the author of six books, including More Money Than God, The Power Law, The Man Who Knew, and The World’s Banker. 

                                                                                                                                          His latest book is The Infinity Machine: Demis Hassabis, DeepMind, and the Quest for Superintelligence.

                                                                                                                                          Please enjoy!

                                                                                                                                          This episode is brought to you by:

                                                                                                                                          • Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim
                                                                                                                                          • AG1 Pro all-in-one nutritional supplement: DrinkAG1.com/Tim
                                                                                                                                          • Wealthfront high-yield cash account: Wealthfront.com/Tim 
                                                                                                                                          • Listen onSpotify
                                                                                                                                            Listen onApple Podcasts
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                                                                                                                                            Sebastian Mallaby, Biographer of Demis Hassabis — Lessons from 100+ AI Insiders on The Race to Superintelligence, The Religion of AI, and Spotting Breakthroughs Early<iframe src="https://www.art19.com/shows/58dacbdc-646e-4585-9914-19c3de11d1ba/episodes/46d28a73-b15a-4146-a5bc-899e0ddd8134/embed?type=micro" style="width: 100%; height: 30px; border: 0 none;" scrolling="no"></iframe>
                                                                                                                                            Additional podcast platforms

                                                                                                                                            Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                                                                                            Transcripts
                                                                                                                                            • This episode
                                                                                                                                            • All episodes
                                                                                                                                            • Show Notes
                                                                                                                                              • Connect with Sebastian Mallaby:
                                                                                                                                              • X

                                                                                                                                                Books
                                                                                                                                                • The Infinity Machine: Demis Hassabis, DeepMind, and the Quest for Superintelligence by Sebastian Mallaby
                                                                                                                                                • More Money Than God: Hedge Funds and the Making of a New Elite by Sebastian Mallaby
                                                                                                                                                • The Power Law: Venture Capital and the Making of the New Future by Sebastian Mallaby
                                                                                                                                                • Ender’s Game by Orson Scott Card
                                                                                                                                                • The Fabric of Reality: The Science of Parallel Universes—and Its Implications by David Deutsch
                                                                                                                                                • Gödel, Escher, Bach: An Eternal Golden Braid by Douglas Hofstadter
                                                                                                                                                • The Organization Man by William H. Whyte
                                                                                                                                                • Recommended Reading, Watching, & Listening
                                                                                                                                                  • Demis Hassabis: How AI Is Unlocking the Secrets of Nature and the Universe | TED Talk
                                                                                                                                                  • Silicon Valley’s Obsession with AI Looks a Lot Like Religion | The MIT Press Reader
                                                                                                                                                  • OpenAI Employees Say Firm’s Chief Scientist Has Been Making Strange Spiritual Claims | Futurism
                                                                                                                                                  • DeepMind’s Shane Legg on Machine Super Intelligence | The Artificial Intelligence Channel
                                                                                                                                                  • The China Shock: Learning from Labor Market Adjustment to Large Changes in Trade | National Bureau of Economic Research
                                                                                                                                                  • Why Neural Net Pioneer Geoffrey Hinton Is Sounding the Alarm on AI | MIT Sloan
                                                                                                                                                  • Existential Risk from Artificial General Intelligence | Wikipedia
                                                                                                                                                  • Anthropic Pulls Its Most Powerful AI Models After US Bars Foreign Access | Time
                                                                                                                                                  • This Is What Convinced Me OpenAI Will Run Out of Money by Sebastian Mallaby | The New York Times
                                                                                                                                                  • A Rational Conversation on Where AI Is Actually Going with Benedict Evans | Lenny’s Podcast
                                                                                                                                                  • Benedict’s Newsletter | Benedict Evans
                                                                                                                                                  • Sebastian Mallaby on Why the U.S. and China Need to Talk Seriously About AI Safety | The Wire China
                                                                                                                                                  • Biden Needs Allies to Keep China and Russia in Check. Here’s How to Do It. by Sebastian Mallaby | The Washington Post
                                                                                                                                                  • U.S.-China AI Race Escalates + Chip Bans Aren’t Working: A Lesson from Nuclear Proliferation | Council on Foreign Relations (The Spillover)
                                                                                                                                                  • The U.S.-China Economic Cold War, with Sebastian Mallaby | Council on Foreign Relations (The President’s Inbox)
                                                                                                                                                  • Khrushchev Loses His Cool | Time
                                                                                                                                                  • Sebastian Mallaby on AI Safety and the Race for Superintelligence | The Good Fight Podcast
                                                                                                                                                  • Google Acquires Artificial Intelligence Startup DeepMind for More Than $500M | TechCrunch
                                                                                                                                                  • Has AI Already Killed How-to Nonfiction? Sales Trends, My Personal Data, and What It Might Mean for the Future | Tim Ferriss
                                                                                                                                                  • The Nobel Prize in Chemistry 2024 (AlphaFold — Hassabis, Jumper, and Baker) | The Nobel Prize
                                                                                                                                                  • Flagship Pioneering Unveils Lila Sciences to Build Superintelligence in Science | Flagship Pioneering
                                                                                                                                                  • “In the Fields of Observation, Chance Favors Only the Prepared Mind.” — Louis Pasteur | Wikiquote
                                                                                                                                                  • Malcolm Butler’s Game-Sealing Interception in Super Bowl XLIX | NFL Films
                                                                                                                                                  • What if Readers Like A.I.-Generated Fiction? by Vauhini Vara | The New Yorker
                                                                                                                                                  • Relevant Tim Ferriss Show Episodes
                                                                                                                                                    • Legendary Investor Bill Gurley on Investing Rules, Finding Outliers, Insights from Jeff Bezos and Howard Marks, Must-Read Books, Creating True Competitive Advantages, and More | The Tim Ferriss Show #651
                                                                                                                                                    • Bill Gurley — Investing in the AI Era, 10 Days in China, and Important Life Lessons | The Tim Ferriss Show #840
                                                                                                                                                    • Max Levchin, PayPal, and Affirm — The Path from the Soviet Union to Building Multi-Billion Dollar Companies | The Tim Ferriss Show #869
                                                                                                                                                    • Films
                                                                                                                                                      • AlphaGo
                                                                                                                                                      • Mad Max
                                                                                                                                                      • The Terminator
                                                                                                                                                      • 2001: A Space Odyssey
                                                                                                                                                      • People
                                                                                                                                                        • Sam Altman
                                                                                                                                                        • Dario Amodei
                                                                                                                                                        • Marc Andreessen
                                                                                                                                                        • Joe Biden
                                                                                                                                                        • Napoleon Bonaparte
                                                                                                                                                        • Nick Bostrom
                                                                                                                                                        • Greg Brockman
                                                                                                                                                        • Malcolm Butler
                                                                                                                                                        • Orson Scott Card
                                                                                                                                                        • David Deutsch
                                                                                                                                                        • John Doerr
                                                                                                                                                        • Benedict Evans
                                                                                                                                                        • David Gammon
                                                                                                                                                        • Bill Gurley
                                                                                                                                                        • HAL 9000
                                                                                                                                                        • Demis Hassabis
                                                                                                                                                        • Geoffrey Hinton
                                                                                                                                                        • Douglas Hofstadter
                                                                                                                                                        • Sebastian Junger
                                                                                                                                                        • Travis Kalanick
                                                                                                                                                        • Dara Khosrowshahi
                                                                                                                                                        • Nikita Khrushchev
                                                                                                                                                        • Yann LeCun
                                                                                                                                                        • Shane Legg
                                                                                                                                                        • Anthony Levandowski
                                                                                                                                                        • Max Levchin
                                                                                                                                                        • Dustin Moskovitz
                                                                                                                                                        • Elon Musk
                                                                                                                                                        • Luke Nosek
                                                                                                                                                        • Louis Pasteur
                                                                                                                                                        • Arthur Patterson
                                                                                                                                                        • Lenny Rachitsky
                                                                                                                                                        • Alec Radford
                                                                                                                                                        • Kevin Rose
                                                                                                                                                        • Ilya Sutskever
                                                                                                                                                        • Peter Thiel
                                                                                                                                                        • Leo Tolstoy
                                                                                                                                                        • Donald Trump
                                                                                                                                                        • Vauhini Vara
                                                                                                                                                        • Cathie Wood
                                                                                                                                                        • Xi Jinping
                                                                                                                                                        • Mark Zuckerberg
                                                                                                                                                        • Companies & Organizations
                                                                                                                                                          • Accel
                                                                                                                                                          • Alphabet
                                                                                                                                                          • Ant Group
                                                                                                                                                          • Anthropic
                                                                                                                                                          • ARK Invest
                                                                                                                                                          • Benchmark
                                                                                                                                                          • DocuSign
                                                                                                                                                          • Facebook
                                                                                                                                                          • Fairchild Semiconductor
                                                                                                                                                          • Founders Fund
                                                                                                                                                          • Genentech
                                                                                                                                                          • Google DeepMind
                                                                                                                                                          • Hikvision
                                                                                                                                                          • Huawei
                                                                                                                                                          • Lila Sciences
                                                                                                                                                          • Mailchimp
                                                                                                                                                          • Meta
                                                                                                                                                          • Mistral
                                                                                                                                                          • OpenAI
                                                                                                                                                          • OpenTable
                                                                                                                                                          • Palantir
                                                                                                                                                          • PayPal
                                                                                                                                                          • Saudi Aramco
                                                                                                                                                          • Shockley Semiconductor Laboratory
                                                                                                                                                          • SpaceX
                                                                                                                                                          • Stargate Project
                                                                                                                                                          • Uber
                                                                                                                                                          • Waymo
                                                                                                                                                          • X (formerly Twitter)
                                                                                                                                                          • Institutions
                                                                                                                                                            • Council on Foreign Relations
                                                                                                                                                            • International Atomic Energy Agency
                                                                                                                                                            • Milken Institute Global Conference
                                                                                                                                                            • Stanford University
                                                                                                                                                            • World Trade Organization
                                                                                                                                                            • AI Systems & Tools
                                                                                                                                                              • AlphaFold
                                                                                                                                                              • AlphaGo
                                                                                                                                                              • ChatGPT (OpenAI)
                                                                                                                                                              • Claude Fable 5 and Claude Mythos 5 (Anthropic)
                                                                                                                                                              • Cloud TPUs
                                                                                                                                                              • Gemini (Google)
                                                                                                                                                              • Gmail
                                                                                                                                                              • Google Maps
                                                                                                                                                              • Google Workspace (“G Suite”)
                                                                                                                                                              • Sora (OpenAI)
                                                                                                                                                              • Concepts
                                                                                                                                                                • AI Winter
                                                                                                                                                                • Artificial General Intelligence (AGI)
                                                                                                                                                                • Bayh–Dole Act
                                                                                                                                                                • The China Shock
                                                                                                                                                                • Cuban Missile Crisis
                                                                                                                                                                • Cultural Revolution
                                                                                                                                                                • Garden Leave
                                                                                                                                                                • Paperclip Maximizer / Instrumental Convergence
                                                                                                                                                                • Pentamind World Championship, Mind Sports Olympiad
                                                                                                                                                                • Recursive Self-Improvement
                                                                                                                                                                • Super Bowl XLIX
                                                                                                                                                                • The Traitorous Eight
                                                                                                                                                                • Transformer Architecture (“Attention Is All You Need”)
                                                                                                                                                                • Treaty on the Non-Proliferation of Nuclear Weapons (NPT)
                                                                                                                                                                • Vibe Coding
                                                                                                                                                                • Timestamps
                                                                                                                                                                  • [00:00:00] Start.
                                                                                                                                                                  • [00:02:11] The twinkly eyed polymath who became Sebastian’s next book.
                                                                                                                                                                  • [00:06:55] Picking the next book project the way a great VC picks a startup.
                                                                                                                                                                  • [00:09:41] Why God keeps crashing the superintelligence party.
                                                                                                                                                                  • [00:11:13] Shane Legg’s grainy 2009 prophecy — and the nervous giggle.
                                                                                                                                                                  • [00:13:11] Ilya Sutskever burns an effigy.
                                                                                                                                                                  • [00:13:54] Demis at 4 a.m., hunting God’s algorithm.
                                                                                                                                                                  • [00:18:43] Super-abundance, Mad Max, and the China shock lesson.
                                                                                                                                                                  • [00:22:39] The kitchen debate with Geoff Hinton that flipped Sebastian.
                                                                                                                                                                  • [00:24:06] Why a zero-percent chance of doom is indefensible.
                                                                                                                                                                  • [00:24:52] Will Washington seize the labs? The Mythos wake-up call.
                                                                                                                                                                  • [00:27:18] Anthropic’s bull case, bear case, and a dead parent’s letter.
                                                                                                                                                                  • [00:33:24] Where Sebastian and Benedict Evans part ways.
                                                                                                                                                                  • [00:38:16] Is the SaaS apocalypse overdone? One word: Palantir.
                                                                                                                                                                  • [00:39:53] The AI friend you’ll never switch.
                                                                                                                                                                  • [00:41:56] Does Google win consumer AI by default?
                                                                                                                                                                  • [00:44:45] Four cities, eight days: China actually talks safety.
                                                                                                                                                                  • [00:47:28] A Cold War non-proliferation playbook for AI.
                                                                                                                                                                  • [00:49:45] Did the chip export controls actually work?
                                                                                                                                                                  • [00:51:49] Burned doves: why Washington swears China won’t talk.
                                                                                                                                                                  • [00:54:56] “By 2028, the race is over” — one lab boss’ bet.
                                                                                                                                                                  • [00:59:11] Inside Hikvision: toddlers, sensors, and US sanctions.
                                                                                                                                                                  • [01:01:07] Bill Gurley’s Uber bet: venture capital perfected.
                                                                                                                                                                  • [01:05:18] Luke Nosek bear-hugs DeepMind into existence.
                                                                                                                                                                  • [01:10:52] Thiel’s heresy: never invest by committee.
                                                                                                                                                                  • [01:11:59] How Founders Fund nearly fumbled the deal of the century.
                                                                                                                                                                  • [01:14:30] Selling to Google for $650M: a secret British heist?
                                                                                                                                                                  • [01:16:41] The Traitorous Eight, gardening leave, and the UK’s to-do list.
                                                                                                                                                                  • [01:20:55] Ender’s Game: “That’s really how I see myself.”
                                                                                                                                                                  • [01:23:42] Too dumb for Gödel, Escher, Bach? Maybe an LLM can help.
                                                                                                                                                                  • [01:25:19] If not Demis or Sam, then Dario.
                                                                                                                                                                  • [01:26:04] My royalties cliff — and what dropped in late 2022.
                                                                                                                                                                  • [01:27:47] Lila Sciences and the labs that run themselves.
                                                                                                                                                                  • [01:31:13] Sebastian’s billboard: “Prepare your mind.”
                                                                                                                                                                  • [01:35:14] The one thing Sebastian will never outsource to AI.
                                                                                                                                                                  • [01:40:09] Parting thoughts.
                                                                                                                                                                  • Sebastian Mallaby Quotes from the Interview

                                                                                                                                                                    “These machines will be smarter than us. They will want to survive. And they can be deceptive, they can obfuscate, they can go behind your back, pretend they’re doing one thing and then actually do another. All of this has been shown in all the tests of the models. And so we put those things together, I think your probability of doom cannot be zero.”

                                                                                                                                                                    — Sebastian Mallaby

                                                                                                                                                                    “For humans, to contemplate annihilation is absurd and the absurd is a close cousin of humor.”

                                                                                                                                                                    — Sebastian Mallaby

                                                                                                                                                                    “All through this topic there is this religious expression because religion is the lexicon for dealing with something that we find too mysterious to really understand.”

                                                                                                                                                                    — Sebastian Mallaby

                                                                                                                                                                    “I think any reasonable person should be both excited and a bit frightened, and that’s just the nature of it. It sounds contradictory, but actually, that’s the only rational response.”

                                                                                                                                                                    — Sebastian Mallaby

                                                                                                                                                                    “We only need to be ahead for the next couple of years, because by 2028 we will get to recursive self-improvement, where the frontier model codes, by itself, the next frontier model, and progress just goes vertical. And at that point, with recursive self-improvement, we’re done, the race is over. Whoever comes first at that point, that’s it.”

                                                                                                                                                                    — Sebastian Mallaby

                                                                                                                                                                    Related Episode

                                                                                                                                                                    Want to hear another conversation with a legendary investor mapping the AI race and the US–China contest? Listen to my conversation with Benchmark general partner Bill Gurley, in which we discussed the AI bubble debate, circular deals and SPV chaos, angel investing in the AI era, his ten-day deep dive across six Chinese cities, the Xiaomi SU7 factory tour, Lei Jun as “the Steve Jobs of China,” America vs. China (lawyers vs. engineers), regulatory capture, why the IPO market is broken, stablecoins putting Visa and Mastercard on notice, and much more.

                                                                                                                                                                    This episode is brought to you by AG1. I’ve taken AG1 for more than a decade. Longtime listeners have heard me call it my nutritional insurance. Here’s the news: they’ve just launched AG1 Pro, designed for people focused on performance and longevity. I’ll be traveling soon, and I’m throwing this in my bag to cover my bases while I travel. Past a certain age, maintaining lean muscle becomes priority number one, and AG1 Pro is formulated to support exactly that. It includes HMB, a clinically studied compound that supports protein synthesis and helps reduce protein breakdown, plus zinc carnosine to support the gut lining. Remember: training is only half the equation. Recovery is where the work compounds, and AG1 Pro is built to support it. It’s NSF Certified for Sport, so what’s on the label is what’s in the pouch. Get your free AG1 Pro Yeti Shaker in the Welcome Kit at Drinkag1.com/Tim.

                                                                                                                                                                    This episode is brought to you by Eight Sleep. Temperature is one of the main causes of poor sleep, and heat is my personal nemesis. But a few years ago, I started using the Pod Cover, and it has transformed my sleep. Eight Sleep has launched their newest generation of the Pod: Pod 5. It cools, it heats, and now it elevates, automatically. With the best temperature performance to date, the Pod 5 ensures you and your partner stay cool in the heat and cozy warm in the cold. Go to eightsleep.com/Tim and use code TIM to get $350 off the Pod—which includes the Cover, Hub, and Base—for a limited time! Click here to claim this deal and unlock your full potential through optimal sleep.

                                                                                                                                                                    This episode is brought to you by Wealthfront! Wealthfront is a financial services platform that offers services to help you save and invest your money. Right now, your cash can earn 3.30% APY—that’s the Annual Percentage Yield—with the Wealthfront Cash Account from its network of program banks. That’s 8 times more interest than a typical savings account at a bank, according to FDIC.gov as of 05/18/2026 (Wealthfront’s 3.30% APY vs. 0.38% average savings rate). Right now, for a limited time, Wealthfront is offering new clients that use my sign-up link an additional 0.75% boost over the base rate for three months, meaning you can get up to 4.05% APY, limited to a $150,000 balance. Terms & Conditions apply. Visit Wealthfront.com/Tim to get started. 

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                                                                                                                                                                    The post Sebastian Mallaby, Biographer of Demis Hassabis — Lessons from 100+ AI Insiders on The Race to Superintelligence, The Religion of AI, and Spotting Breakthroughs Early (#870) appeared first on The Blog of Author Tim Ferriss.

                                                                                                                                                                    1 hr 47 min
                                                                                                                                                                  • Max Levchin, PayPal and Affirm — The Path from The Soviet Union to Building Multi-Billion Dollar Companies (Plus: Real-World Socialism vs. Capitalism) (#869)

                                                                                                                                                                    Max Levchin (@mlevchin) is a serial entrepreneur, computer scientist, philanthropist, and active investor in more than 100 startups. He is the founder and CEO of Affirm, the payment network that empowers consumers and helps merchants drive growth. He is also the co-founder and chairman of Glow, a data-driven fertility company. Both companies were created and launched from his San Francisco-based innovation lab, SciFi VC (formerly HVF [Hard, Valuable, Fun]). Max was one of the original co-founders of PayPal, where he served as the chief technology officer until its acquisition by eBay in 2002. In 2002, he was named to MIT Technology Review’s TR100 as one of the top 100 innovators in the world as well as Innovator of the Year.

                                                                                                                                                                    Prior to HVF, Max founded, and was CEO of, Slide, a personal media-sharing service, which was acquired by Google in 2010. Max also helped create Yelp, where he served as chairman of its board of directors from its founding in 2005 until 2015. He served on the board for Yahoo! from 2012 to 2015.

                                                                                                                                                                    Max was born in Kyiv, Ukraine, before moving to the United States and settling in Chicago in 1991. He holds a B.S. in computer science from the University of Illinois at Urbana-Champaign, where he founded and led four other technology startups.

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                                                                                                                                                                      Transcripts
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                                                                                                                                                                      • SELECTED LINKS FROM THE EPISODE

                                                                                                                                                                        Connect with Max Levchin

                                                                                                                                                                        Website | SciFi VC | Affirm | Glow | Twitter

                                                                                                                                                                        Relevant Resources
                                                                                                                                                                        • Interview with Computer Scientist and Internet Entrepreneur Max Levchin | Men’s Journal
                                                                                                                                                                        • PayPal Cofounder Max Levchin’s Traumatic Debt Experience Motivated Him to Create Affirm | Fortune
                                                                                                                                                                        • Max Levchin Wants to Revolutionize the $2.6 Trillion Consumer Credit Market | Yahoo Finance
                                                                                                                                                                        • Max Levchin, Founder & CEO of Affirm, on How HVF (Hard, Valuable, Fun) Has Guided His Founder Journey | Notable Perspectives
                                                                                                                                                                        • In Data We Trust: Max Levchin Blows Up Consumer Finance | Mixpanel
                                                                                                                                                                        • Max Levchin: Changemakers 2023 | Money
                                                                                                                                                                        • Quotations from the Film Ronin | Wikiquote
                                                                                                                                                                        • Kyoto Scientists Enhance Mind-Reading Technology | Kyoto University
                                                                                                                                                                        • Reading Minds with Ultrasound: A Less-Invasive Technique to Decode the Brain’s Intentions | Caltech
                                                                                                                                                                        • Seeing the Value of Blind Signatures | History of Bitcoin
                                                                                                                                                                        • How Peter Thiel Almost Created Bitcoin | John Coogan
                                                                                                                                                                        • Is Bitcoin Just a Flash in the Pan? Peter Thiel Responds | Mind Matters
                                                                                                                                                                        • William Gibson, The Art of Fiction No. 211 | The Paris Review
                                                                                                                                                                        • Quotations from William Gibson | Wikiquote
                                                                                                                                                                        • Quotations from the Book The Master and Margarita | Wikiquote
                                                                                                                                                                        • How Did the Soviet Union Actually Work? | Look Back History
                                                                                                                                                                        • A Healthy Economy Requires a Balance between Socialism and Capitalism | Brewminate
                                                                                                                                                                        • Fermented-Food Diet Increases Microbiome Diversity, Decreases Inflammatory Proteins | Stanford Medicine
                                                                                                                                                                        • Curiosities of Kyiv: Kyiv Velodrome | Kyiv Post
                                                                                                                                                                        • What Is Affirm? | Affirm
                                                                                                                                                                        • Millennials Find Banks Irrelevant (And Why That Matters in Banking) | The Financial Brand
                                                                                                                                                                        • Why It’s Time To Re-Imagine the Financial Services Industry by Max Levchin | LinkedIn
                                                                                                                                                                        • What Anthropic, OpenAI, and Google Are Each Doing in Agentic Commerce | Digital Commerce 360
                                                                                                                                                                        • Anthropic Steps Up in the Agentic Commerce Race | Surf the Wave
                                                                                                                                                                        • Chicory and Other Caffeine-Free Coffee Substitutes | Wikipedia
                                                                                                                                                                        • The Building in Public How-To Guide by Gaby Goldberg | Medium
                                                                                                                                                                        • Relevant Episodes of The Tim Ferriss Show
                                                                                                                                                                          • Jason Portnoy of PayPal, Palantir, and More | The Tim Ferriss Show #600
                                                                                                                                                                          • Interview with Peter Thiel, Billionaire Investor and Company Creator | The Tim Ferriss Show #28
                                                                                                                                                                          • Kevin Kelly — AI, Virtual Reality, and The Inevitable | The Tim Ferriss Show #164
                                                                                                                                                                          • Edward O. Thorp, A Man for All Markets — Beating Blackjack and Roulette, Beating the Stock Market, Spotting Bernie Madoff Early, and Knowing When Enough Is Enough | The Tim Ferriss Show #596
                                                                                                                                                                          • Master Investor Ed Thorp on How to Think for Yourself, Mental Models for the Second Half of Life, How to Be Inner-Directed, How Basic Numeracy Is a Superpower, and The Dangers of Investing Fads | The Tim Ferriss Show #604
                                                                                                                                                                          • Books
                                                                                                                                                                            • Alexander Hamilton by Ron Chernow
                                                                                                                                                                            • Cryptonomicon by Neal Stephenson
                                                                                                                                                                            • A Failure of Nerve: Leadership in the Age of the Quick Fix by Edwin Friedman
                                                                                                                                                                            • Grant by Ron Chernow
                                                                                                                                                                            • The House of Morgan: An American Banking Dynasty and the Rise of Modern Finance by Ron Chernow
                                                                                                                                                                            • Influence, New and Expanded: The Psychology of Persuasion by Robert Cialdini
                                                                                                                                                                            • A Man for All Markets: From Las Vegas to Wall Street, How I Beat the Dealer and the Market by Edward O. Thorp
                                                                                                                                                                            • Mark Twain by Ron Chernow
                                                                                                                                                                            • The Master and Margarita by Mikhail Bulgakov (Pevear and Volokhonsky translation)
                                                                                                                                                                            • A Mind at Play: How Claude Shannon Invented the Information Age by Jimmy Soni and Rob Goodman
                                                                                                                                                                            • Neuromancer by William Gibson
                                                                                                                                                                            • 7 Powers: The Foundations of Business Strategy by Hamilton Helmer
                                                                                                                                                                            • Shut Up, Legs!: My Wild Ride On and Off the Bike by Jens Voigt and James Startt
                                                                                                                                                                            • Snow Crash by Neal Stephenson
                                                                                                                                                                            • Titan: The Life of John D. Rockefeller, Sr. by Ron Chernow
                                                                                                                                                                            • Tribe of Mentors: Short Life Advice from the Best in the World by Timothy Ferriss
                                                                                                                                                                            • Washington: A Life by Ron Chernow
                                                                                                                                                                            • Films
                                                                                                                                                                              • Akira (1988)
                                                                                                                                                                              • Nosferatu (1922)
                                                                                                                                                                              • Paprika (2006)
                                                                                                                                                                              • Ronin (1998)
                                                                                                                                                                              • Seven Samurai (1954)
                                                                                                                                                                              • People
                                                                                                                                                                                • Mikhail Bulgakov
                                                                                                                                                                                • David Chaum
                                                                                                                                                                                • Ron Chernow
                                                                                                                                                                                • Robert Cialdini
                                                                                                                                                                                • Arthur C. Clarke
                                                                                                                                                                                • Richard Feynman
                                                                                                                                                                                • Edwin Friedman
                                                                                                                                                                                • Murray Gell-Mann
                                                                                                                                                                                • William Gibson
                                                                                                                                                                                • Reed Hastings
                                                                                                                                                                                • Hamilton Helmer
                                                                                                                                                                                • Reid Hoffman
                                                                                                                                                                                • Sami Inkinen
                                                                                                                                                                                • Alan Kay
                                                                                                                                                                                • Nellie Minkova
                                                                                                                                                                                • Satoshi Nakamoto
                                                                                                                                                                                • Luke Nosek
                                                                                                                                                                                • Nostradamus
                                                                                                                                                                                • John D. Rockefeller
                                                                                                                                                                                • Claude Shannon
                                                                                                                                                                                • Joseph Stalin
                                                                                                                                                                                • Neal Stephenson
                                                                                                                                                                                • Peter Thiel
                                                                                                                                                                                • Ed Thorp
                                                                                                                                                                                • Jens Voigt
                                                                                                                                                                                • Companies & Organizations
                                                                                                                                                                                  • Affirm
                                                                                                                                                                                  • Boston Dynamics
                                                                                                                                                                                  • DigiCash
                                                                                                                                                                                  • DoorDash
                                                                                                                                                                                  • eBay
                                                                                                                                                                                  • Instacart
                                                                                                                                                                                  • Men’s Journal
                                                                                                                                                                                  • PayPal
                                                                                                                                                                                  • SciFi VC
                                                                                                                                                                                  • Virta Health
                                                                                                                                                                                  • WeChat
                                                                                                                                                                                  • Yelp
                                                                                                                                                                                  • AI Tools
                                                                                                                                                                                    • ChatGPT | OpenAI
                                                                                                                                                                                    • Claude / Claude Code | Anthropic
                                                                                                                                                                                    • Coffee Tools & Products
                                                                                                                                                                                      • Acaia Orbit Grinder
                                                                                                                                                                                      • AeroPress
                                                                                                                                                                                      • Breville
                                                                                                                                                                                      • Bulletproof
                                                                                                                                                                                      • Chemex
                                                                                                                                                                                      • Cometeer
                                                                                                                                                                                      • Decent Espresso
                                                                                                                                                                                      • La Marzocco
                                                                                                                                                                                      • Niche Zero Grinder
                                                                                                                                                                                      • Orphan Espresso Lido
                                                                                                                                                                                      • Weber Workshops
                                                                                                                                                                                      • Concepts & References
                                                                                                                                                                                        • Agentic Commerce (A-Commerce)
                                                                                                                                                                                        • Buy Now, Pay Later (BNPL)
                                                                                                                                                                                        • Homo Sovieticus
                                                                                                                                                                                        • Information Theory
                                                                                                                                                                                        • Metaverse
                                                                                                                                                                                        • Timestamps
                                                                                                                                                                                          • [00:00:00] Start.
                                                                                                                                                                                          • [00:02:50] The Ronin line that rewired how Max makes every decision.
                                                                                                                                                                                          • [00:06:09] Paprika-style brain-computer interfaces.
                                                                                                                                                                                          • [00:09:09] PayPal’s founders lived inside a Neal Stephenson novel.
                                                                                                                                                                                          • [00:19:21] Transformation via Neuromancer and Snow Crash.
                                                                                                                                                                                          • [00:23:40] The book that found Max his wife.
                                                                                                                                                                                          • [00:29:24] The real secret to a great marriage.
                                                                                                                                                                                          • [00:38:29] What’s worth tracking, and what’s not.
                                                                                                                                                                                          • [00:44:13] A scrawny kid, a clarinet, and a Kyiv velodrome.
                                                                                                                                                                                          • [00:46:55] What going all-out on a bike actually gives you.
                                                                                                                                                                                          • [00:51:02] The mantra by which Max rides.
                                                                                                                                                                                          • [00:53:02] A Soviet kid’s fear of socialism.
                                                                                                                                                                                          • [01:02:48] Making a profit without destroying society.
                                                                                                                                                                                          • [01:04:31] What is Affirm, and why did every banker say it would fail?
                                                                                                                                                                                          • [01:20:18] Why the best mathematicians eschew the lending industry.
                                                                                                                                                                                          • [01:23:50] Does agentic commerce break Affirm, or supercharge it?
                                                                                                                                                                                          • [01:28:01] A PhD-level financial advisor in everyone’s pocket.
                                                                                                                                                                                          • [01:29:58] How close are we to buying anything through one AI chat?
                                                                                                                                                                                          • [01:36:32] Improving your coffee: cheap, intermediate, and Bugatti options.
                                                                                                                                                                                          • [01:44:33] The books every first-time founder should actually read.
                                                                                                                                                                                          • [01:48:08] Claude Shannon, Ed Thorp, and the joy of playful genius.
                                                                                                                                                                                          • [01:51:00] Why physical books still beat every digital reading experience.
                                                                                                                                                                                          • [01:51:44] Parting thoughts.
                                                                                                                                                                                          • Max Levchin Quotes from the Interview

                                                                                                                                                                                            “The attempt to impress your mate on a daily basis is the secret to the best marriage.”

                                                                                                                                                                                            — Max Levchin

                                                                                                                                                                                            “The best recipe we’ve discovered as humanity is capitalism, a force for constant creative destruction where you build the next thing better than the other guy.”

                                                                                                                                                                                            — Max Levchin

                                                                                                                                                                                            “It’s okay to make a little bit less money if you are able to create something that’s societally more successful, more important.”

                                                                                                                                                                                            — Max Levchin

                                                                                                                                                                                            “If you tell an entrepreneur over and over again, ‘This thing will never work unless someone does X,’ the natural response is, ‘Well, I will do X and see if it works.'”

                                                                                                                                                                                            — Max Levchin

                                                                                                                                                                                            “The job apocalypse people are proclaiming is so goofy. There’s so much opportunity to build so many exciting things for everyone, not just a Silicon Valley startup.”

                                                                                                                                                                                            — Max Levchin

                                                                                                                                                                                            Want to hear another conversation with a mathematician who aimed his big brain at real-world money? Listen to my first conversation with legendary blackjack player, quant pioneer, and hedge fund manager Edward O. Thorp, in which we discussed beating blackjack and roulette with the first wearable computer, his friendship with Claude Shannon, what convinced him Warren Buffett would become the richest man in the world, spotting Bernie Madoff’s fraud 17 years early, mental models like externalities and the tragedy of the commons, long-term thinking, knowing when enough is enough, and much more.

                                                                                                                                                                                            This episode is brought to you by Shopify! Shopify is one of my favorite platforms and one of my favorite companies. Shopify is designed for anyone to sell anywhere, giving entrepreneurs the resources once reserved for big business. In no time flat, you can have a great-looking online store that brings your ideas to life, and you can have the tools to manage your day-to-day and drive sales. Go to Shopify.com/Tim to sign up for a one-dollar-per-month trial period. It’s a great deal for a great service, so I encourage you to check it out. Take your business to the next level today by visiting Shopify.com/Tim.

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                                                                                                                                                                                            This episode is brought to you buy ProLon! One name that has come up on this podcast more than once is Dr. Valter Longo, a USC professor with decades of peer-reviewed research on fasting, nutrition, and aging. I regularly fast and have done a lot of experiments with fasting over more than a decade, and it has been one of the most incredible unlocks that I have found for both near- and long-term physical and mental health.

                                                                                                                                                                                            But fasting can be really hard, and that is why Dr. Longo, best known for the Fast Mimicking Diet (FMD), developed ProLon. For 5 days, you’re able to get the benefits of fasting—including autophagy, your body’s cellular, self cleanup process—all while eating real, structured, plant-based meals. In scientific studies, 5-day cycles of the Fast Mimicking Diet improved markers tied to metabolic health and biological aging and helped people drop fat while holding onto lean muscle. And ProLon makes it easy: it comes in one box, everything is clearly laid out, and there’s no guesswork. For a limited time, Prolon is offering my listeners 15% off sitewide, plus a $40 bonus gift when you subscribe to their 5-day program. Just visit ProLonLife.com/Tim.

                                                                                                                                                                                            The post Max Levchin, PayPal and Affirm — The Path from The Soviet Union to Building Multi-Billion Dollar Companies (Plus: Real-World Socialism vs. Capitalism) (#869) appeared first on The Blog of Author Tim Ferriss.

                                                                                                                                                                                            1 hr 59 min
                                                                                                                                                                                          • Tim’s Founder Kitchen — From Brainstorm to the President’s Office in Two Months (Featuring Jake Becraft, Strand Therapeutics) (#868)

                                                                                                                                                                                            “What I want the world to understand is that we are standing right now on the precipice of a revolution in genetic medicine.” — Jake Becraft

                                                                                                                                                                                            Jake Becraft is the CEO and co-founder of Strand Therapeutics, a company building one of the most advanced programmable genetic medicine platforms in biotechnology. Under his leadership, Strand is redefining what RNA medicines can do by enabling cell-selective targeting and therapeutic payload delivery inside the body, unlocking a new class of precision genetic therapies. He has guided the company from its founding vision through platform development and into clinical translation, positioning Strand at the forefront of next generation RNA therapeutics.

                                                                                                                                                                                            Beyond his role at Strand, Dr. Becraft is an influential voice in the national biotechnology landscape. He engages and advises policymakers, defense leaders, and industry stakeholders on biosecurity, innovation strategy, and strengthening American competitiveness in advanced biotechnology. Trained as a synthetic biologist at MIT, he operates at the intersection of science, entrepreneurship, and policy, focused on building both the companies and the institutional frameworks required to secure the future of programmable medicine.

                                                                                                                                                                                            He received his Ph.D. in Biological Engineering and Synthetic Biology from MIT. He serves on the board of the Biotechnology Innovation Organization (BIO) and the Massachusetts Biotechnology Council (MassBio).

                                                                                                                                                                                            Please enjoy!

                                                                                                                                                                                            This episode is brought to you by:

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                                                                                                                                                                                              Transcripts
                                                                                                                                                                                              • This episode
                                                                                                                                                                                              • All episodes
                                                                                                                                                                                              • SELECTED LINKS FROM THE EPISODE
                                                                                                                                                                                                • Connect with Jacob Becraft:
                                                                                                                                                                                                • Twitter | Strand Therapeutics

                                                                                                                                                                                                  Books & Recommended Reading
                                                                                                                                                                                                  • Genentech: The Beginnings of Biotech by Sally Smith Hughes | Amazon
                                                                                                                                                                                                  • The US Can’t Afford to Offshore Clinical Trials to China by Jacob Becraft | The Washington Post
                                                                                                                                                                                                  • Strand Therapeutics Announces Initial First-in-Human Phase 1 Data for STX-001 at the 2025 ASCO Annual Meeting | BioSpace
                                                                                                                                                                                                  • STX-001 ASCO Poster | Journal of Clinical Oncology
                                                                                                                                                                                                  • The Nobel Prize: Checkpoint Inhibitors | American Journal of Managed Care
                                                                                                                                                                                                  • Scientists Create In Vivo CAR-T Therapy That Kills Cancer Cells Without Chemotherapy | Innovative Genomics Institute
                                                                                                                                                                                                  • mRNA Startup Strand Therapeutics Lands $52M to “Program” New Cancer Therapies | MedCity News
                                                                                                                                                                                                  • The Abscopal Effect in the Era of Checkpoint Inhibitors | National Library of Medicine
                                                                                                                                                                                                  • Step 1: Collect Underpants, Step 2: ?, Step 3: Profit | Know Your Meme
                                                                                                                                                                                                  • Biologics: The Role of Delivery Systems in Improved Therapy | Biologics
                                                                                                                                                                                                  • How the Late Genzyme CEO Henri Termeer Created the Orphan Drug Industry | BioCentury
                                                                                                                                                                                                  • The Orphan Drug Act (ODA) | Wikipedia
                                                                                                                                                                                                  • The Recent Large Reduction in Space Launch Cost | NASA Technical Reports Server
                                                                                                                                                                                                  • FDA Rejects MDMA, Disappointing Drugmaker Lykos and the Psychedelics Industry | NPR
                                                                                                                                                                                                  • Methylone: Distinct Pharmacological and Mechanistic Effects Compared with MDMA | Transcend Therapeutics
                                                                                                                                                                                                  • Curing HIV — How Far Have We Come? | amfAR
                                                                                                                                                                                                  • How Has US Spending on Healthcare Changed over Time? | Peterson-KFF Health System Tracker
                                                                                                                                                                                                  • Strand Tx CEO Jake Becraft Weighs in on FDA’s IND Reform, China | Fierce Biotech
                                                                                                                                                                                                  • Testimony of Dr. Jacob Becraft Before the House Select Committee on the CCP | US House of Representatives
                                                                                                                                                                                                  • Why More Biotechs Are Starting Trials in Australia | Clinical Leader
                                                                                                                                                                                                  • SpaceX Vehicles: From Falcon 1 to Starship | SpaceX
                                                                                                                                                                                                  • Strand’s Flywheel: Platforms for Tumor and T-Cell Delivery | Kinnevik
                                                                                                                                                                                                  • Domino’s Pizza Turnaround Case Study | Dennis Food Service
                                                                                                                                                                                                  • Rides for Vaccinations | Uber Impact
                                                                                                                                                                                                  • AlphaFold: Predicting Protein Structures with AI | Google DeepMind
                                                                                                                                                                                                  • Elon Musk Went from Having 180 Million to Nearly Losing Everything | Leading Entrepreneurs
                                                                                                                                                                                                  • All of Jeff Bezos’ Amazon Letters to Shareholders, 1997–2020 | Quartr
                                                                                                                                                                                                  • AWS: Amazon’s “Side Hustle” That Reshaped the Cloud | About Amazon
                                                                                                                                                                                                  • How Josh Kushner Built Thrive Capital and Became a Billionaire Startup Investor | Fortune
                                                                                                                                                                                                  • COVID-19 Isn’t Political; Its Response Shouldn’t Be Politicized | Johns Hopkins Bloomberg School of Public Health
                                                                                                                                                                                                  • From Insulin to Humulin: The Story of the First Genetically Engineered Drug | Genetics Unzipped
                                                                                                                                                                                                  • Herceptin (Trastuzumab): The First HER2-Targeted Cancer Therapy | Genentech
                                                                                                                                                                                                  • This Month in 1989: The Creation of Bristol-Myers Squibb | PMLiVE
                                                                                                                                                                                                  • “Short the Launch”: Biotech from Bust to Boom | BayBridge Bio
                                                                                                                                                                                                  • Arthur D. Levinson: From Genentech CEO to Apple Chairman | The Franklin Institute
                                                                                                                                                                                                  • Apple, Its Control Over the iPhone, and The Internet | Matthew Ball
                                                                                                                                                                                                  • How Smartphones Changed Music and the Music Industry | Hypebot
                                                                                                                                                                                                  • This May Be the Most Important Medical Story of the Decade | The New York Times
                                                                                                                                                                                                  • Movies
                                                                                                                                                                                                    • Sophie’s Choice | Prime Video
                                                                                                                                                                                                    • Companies
                                                                                                                                                                                                      • Strand Therapeutics
                                                                                                                                                                                                      • Amazon
                                                                                                                                                                                                      • Andreessen Horowitz
                                                                                                                                                                                                      • Anthropic
                                                                                                                                                                                                      • Apple
                                                                                                                                                                                                      • Amazon Web Services (AWS)
                                                                                                                                                                                                      • BlackBerry
                                                                                                                                                                                                      • Bristol Myers Squibb (BMS)
                                                                                                                                                                                                      • DeepMind
                                                                                                                                                                                                      • Domino’s Pizza
                                                                                                                                                                                                      • Facebook
                                                                                                                                                                                                      • Genentech
                                                                                                                                                                                                      • Genzyme
                                                                                                                                                                                                      • Google
                                                                                                                                                                                                      • Holobiome
                                                                                                                                                                                                      • Merck
                                                                                                                                                                                                      • Meta
                                                                                                                                                                                                      • Microsoft
                                                                                                                                                                                                      • Moderna
                                                                                                                                                                                                      • Netflix
                                                                                                                                                                                                      • The New York Times
                                                                                                                                                                                                      • OpenAI
                                                                                                                                                                                                      • PayPal
                                                                                                                                                                                                      • PickFu
                                                                                                                                                                                                      • Playground Global
                                                                                                                                                                                                      • Polymarket
                                                                                                                                                                                                      • SpaceX
                                                                                                                                                                                                      • Spotify
                                                                                                                                                                                                      • Sweetgreen
                                                                                                                                                                                                      • Tesla
                                                                                                                                                                                                      • Thrive Capital
                                                                                                                                                                                                      • Uber
                                                                                                                                                                                                      • Uber Eats
                                                                                                                                                                                                      • The Washington Post
                                                                                                                                                                                                      • Zenno
                                                                                                                                                                                                      • Zip2
                                                                                                                                                                                                      • Institutions & Organizations
                                                                                                                                                                                                        • American Society of Clinical Oncology (ASCO)
                                                                                                                                                                                                        • Advanced Research Projects Agency for Health (ARPA-H)
                                                                                                                                                                                                        • Center for Biologics Evaluation and Research (CBER)
                                                                                                                                                                                                        • Congress (US)
                                                                                                                                                                                                        • Defense Advanced Research Projects Agency (DARPA)
                                                                                                                                                                                                        • Department of Health (Abu Dhabi)
                                                                                                                                                                                                        • European Medicines Agency (EMA)
                                                                                                                                                                                                        • Food and Drug Administration (FDA)
                                                                                                                                                                                                        • Institutional Review Board (IRB)
                                                                                                                                                                                                        • Medicaid
                                                                                                                                                                                                        • Medicare
                                                                                                                                                                                                        • MIT
                                                                                                                                                                                                        • MIT Media Lab
                                                                                                                                                                                                        • MD Anderson Cancer Center
                                                                                                                                                                                                        • Memorial Sloan Kettering Cancer Center
                                                                                                                                                                                                        • Nobel Prize
                                                                                                                                                                                                        • Saisei Foundation
                                                                                                                                                                                                        • The White House
                                                                                                                                                                                                        • Concepts & Therapies
                                                                                                                                                                                                          • 80/20 Rule (Pareto Principle)
                                                                                                                                                                                                          • Abscopal Effect in Oncology
                                                                                                                                                                                                          • American Society of Clinical Oncology (ASCO) Annual Meeting
                                                                                                                                                                                                          • Australia’s Clinical Trial Notification (CTN) Scheme
                                                                                                                                                                                                          • CAR-T Cell Therapy: Cost and Manufacturing Challenges
                                                                                                                                                                                                          • The Central Dogma of Molecular Biology (DNA -> RNA -> Protein)
                                                                                                                                                                                                          • Checkpoint Inhibitors and Cancer Immunotherapy
                                                                                                                                                                                                          • Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
                                                                                                                                                                                                          • Cost of Goods Sold (COGS)
                                                                                                                                                                                                          • Cutaneous vs. Visceral Metastases in Melanoma
                                                                                                                                                                                                          • FDA Investigational New Drug (IND) Application
                                                                                                                                                                                                          • First Principles Thinking
                                                                                                                                                                                                          • In Vivo CAR-T Cell Therapy
                                                                                                                                                                                                          • Institutional Review Boards (IRBs) and Clinical Trial Oversight
                                                                                                                                                                                                          • Kaplan-Meier Survival Curves
                                                                                                                                                                                                          • Keytruda (Pembrolizumab) by Merck
                                                                                                                                                                                                          • Opdivo (Nivolumab) by Bristol Myers Squibb
                                                                                                                                                                                                          • mRNA-Based Therapeutics
                                                                                                                                                                                                          • mRNA Vaccines for COVID-19
                                                                                                                                                                                                          • Strand’s STX-001: Phase 1 Trial in Solid Tumors
                                                                                                                                                                                                          • Turing Test
                                                                                                                                                                                                          • People
                                                                                                                                                                                                            • Jeff Bezos
                                                                                                                                                                                                            • Jennifer Doudna
                                                                                                                                                                                                            • Jamie Heywood
                                                                                                                                                                                                            • Jony Ive
                                                                                                                                                                                                            • Steve Jobs
                                                                                                                                                                                                            • Steve Jurvetson
                                                                                                                                                                                                            • Baby KJ
                                                                                                                                                                                                            • Josh Kushner
                                                                                                                                                                                                            • Art Levinson
                                                                                                                                                                                                            • Martin Makary
                                                                                                                                                                                                            • Elon Musk
                                                                                                                                                                                                            • Sundar Pichai
                                                                                                                                                                                                            • Vinay Prasad
                                                                                                                                                                                                            • Phil Strandwitz
                                                                                                                                                                                                            • Henri Termeer
                                                                                                                                                                                                            • Alan Turing
                                                                                                                                                                                                            • Relevant Episodes
                                                                                                                                                                                                              • Rick Doblin — The Psychedelic Domino That Tips All Others (#440) | The Tim Ferriss Show
                                                                                                                                                                                                              • Dr. Suresh Muthukumaraswamy — LSD Microdosing, Classical Psychedelics vs. Ketamine, Science and Speed in New Zealand (#619) | The Tim Ferriss Show
                                                                                                                                                                                                              • Steve Jurvetson — How to Pick the Future, Quantum Computing, SpaceX, Tesla, and More (#714) | The Tim Ferriss Show
                                                                                                                                                                                                              • Walter Isaacson on CRISPR, Jennifer Doudna, Gene Editing, and the Future of the Human Race (#503) | The Tim Ferriss Show
                                                                                                                                                                                                              • TIMESTAMPS
                                                                                                                                                                                                                • [00:00:00] Start.
                                                                                                                                                                                                                • [00:06:07] What Strand does.
                                                                                                                                                                                                                • [00:08:19] The Boston dinner.
                                                                                                                                                                                                                • [00:11:05] The image of a body riddled with cancer.
                                                                                                                                                                                                                • [00:15:05] What stuck for the muggles in the pitch deck.
                                                                                                                                                                                                                • [00:17:14] A good drug vs. a good product.
                                                                                                                                                                                                                • [00:19:40] Tricking cancer into snitching on itself.
                                                                                                                                                                                                                • [00:27:38] The abscopal effect.
                                                                                                                                                                                                                • [00:34:04] Potency, specificity, and delivery.
                                                                                                                                                                                                                • [00:35:46] First principles thinking.
                                                                                                                                                                                                                • [00:36:38] The precipice of a revolution.
                                                                                                                                                                                                                • [00:41:14] The thousand people in the room.
                                                                                                                                                                                                                • [00:48:38] Psychedelic medicine as a cautionary tale.
                                                                                                                                                                                                                • [00:51:17] What actually catches a policymaker’s attention.
                                                                                                                                                                                                                • [00:53:42] Breakthrough vs. incremental.
                                                                                                                                                                                                                • [00:54:55] What’s in it for the policymakers?
                                                                                                                                                                                                                • [00:58:08] The 80/20 wish list.
                                                                                                                                                                                                                • [01:01:31] Australia’s CTN system.
                                                                                                                                                                                                                • [01:03:51] Sheep, psychedelics, and red-tape arbitrage.
                                                                                                                                                                                                                • [01:05:22] China’s clinical-trial flywheel vs. slow-motion American loss.
                                                                                                                                                                                                                • [01:06:53] The bicoastal biotech ethos.
                                                                                                                                                                                                                • [01:08:10] Can the FDA actually pull this off?
                                                                                                                                                                                                                • [01:12:12] The Sophie’s Choice of pharma development.
                                                                                                                                                                                                                • [01:14:16] Lost arts of founder mode.
                                                                                                                                                                                                                • [01:15:23] Rockets for tumors, T-cells, and beyond.
                                                                                                                                                                                                                • [01:19:16] Viral in policy circles.
                                                                                                                                                                                                                • [01:23:09] The Washington Post headline and the PickFu split test.
                                                                                                                                                                                                                • [01:27:56] Solution-first storytelling.
                                                                                                                                                                                                                • [01:33:54] RNA medicine and platform therapeutics.
                                                                                                                                                                                                                • [01:39:17] Moderna’s 62 days.
                                                                                                                                                                                                                • [01:40:33] Uber Eats and the de-risked launch.
                                                                                                                                                                                                                • [01:44:17] CEO blockers.
                                                                                                                                                                                                                • [01:45:52] Where’s biotech’s SpaceX moment?
                                                                                                                                                                                                                • [01:46:53] Elon Musk betting black on the wheel.
                                                                                                                                                                                                                • [01:51:55] AWS and the post-conviction / pre-consensus window.
                                                                                                                                                                                                                • [01:58:47] COVID politicization.
                                                                                                                                                                                                                • [01:59:46] Insulin, growth hormone, and the original platform story.
                                                                                                                                                                                                                • [02:01:35] Biotech as pharma’s little brother.
                                                                                                                                                                                                                • [02:03:29] More recent role models, Apple edition.
                                                                                                                                                                                                                • [02:04:50] Art Levinson, Steve Jobs, and the biotech-tech crossover.
                                                                                                                                                                                                                • [02:06:25] The iPhone as a delivery platform.
                                                                                                                                                                                                                • [02:08:25] Spotify’s problem and the future of bespoke medicine.
                                                                                                                                                                                                                • [02:10:07] Baby KJ and the limits of liver-only solutions.
                                                                                                                                                                                                                • [02:11:19] Parting thoughts.
                                                                                                                                                                                                                • JACOB BECRAFT QUOTES FROM THE INTERVIEW

                                                                                                                                                                                                                  “Our goal at Strand, and our challenge, is building drugs today that impact patients’ lives. We’re not a research institute. Our goal is not to do really cool research on mice and join the ranks of people who have cured mice of cancer. There’s millions of them. There could be a Nobel Prize every five minutes for someone who’s cured a mouse of cancer. Our goal is to cure human beings of human-being cancer. Our goal is to cure human beings of human-being diseases, and do so in a safe, effective, scalable way that impacts a person’s life as little as possible. And that is what we’re building.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “What I want the world to understand is that we are standing right now on the precipice of a revolution in genetic medicine.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “Everyone wants to cure cancer. I don’t need a story behind curing cancer. I just need a story about how we’re going to get there and how curing cancer is actually going to be one step on the road to solving disease writ large.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “What we are in the midst of right now is the United States massively losing to China. China has built an industrialized version of clinical trial infrastructure for first-in-human trials that is so efficient and massively quick that they’re just able to go faster and cheaper into the thing that matters most, which is first-in-human trials. So the United States is actually in the process of very rapidly, as a country, falling behind China because what started as a place for American companies to come run clinical trials to get data and then take it to the FDA and then do larger trials in the United States has now created a flywheel structure within China where now just Chinese companies run their clinical trials faster than the American companies and then bring their Chinese-discovered drugs to the United States.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “No one will learn until they care.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “The biotechnology industry will be dragged kicking and screaming into the future, or it will be built up in a new way from new players.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “If some bullshit hype filters into this, it’s worth it in order to take the correct swings at the truly big ideas, because one out of 10 transformations is better than seven out of 10 logical steps forward.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “In low odds games, games where there’s a very low odds of success statistically, if you don’t go 100 percent all in, the odds will be zero.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  “When I look at some of those great investors who have made these high-conviction bets, it seems like they’re able to identify this moment in time for companies that is post-conviction, pre-consensus. The ones who know we’re post-conviction, we’re no longer saying, ‘Can we do this?’ We’re like, ‘Oh, my God, this is going to work.’ But it’s pre-consensus because not everyone has caught on yet or not everyone is convinced.”

                                                                                                                                                                                                                  — Jacob Becraft

                                                                                                                                                                                                                  Want to hear another episode with a physician-founder building a new class of medicine? Listen to my conversation with Dr. Kevin Tracey, president and CEO of the Feinstein Institutes for Medical Research, in which we discussed the birth of bioelectronic medicine, stimulating the vagus nerve to tame inflammation, the inflammatory reflex, treating rheumatoid arthritis and Crohn’s disease, SetPoint Medical’s FDA approval journey, alleviating depression and autoimmune disorders, building devices that replace drugs, and much more.

                                                                                                                                                                                                                  This episode is brought to you by Incogni: erase your personal data from the web and prevent scams, fraud, and identity theft! Incogni automatically removes your information across 420+ data brokers (1,000+ additional sites covered in their Unlimited plan), and they keep it scrubbed automatically. Deloitte has independently verified the headline numbers (245M+ removal requests), and the company adheres to AICPA SOC security standards, with an A+ rating from the BBB. And with their Unlimited plan, if you find your info on a site they don’t automatically monitor, just send them the link, and their privacy team will handle it. ​Protect yourself now with Incogni. Go to Incogni.com/Tim to get 60% off their annual plan.

                                                                                                                                                                                                                  This episode is brought to you by Helix Sleep! Helix was named best overall mattress of 2026 by Forbes, Wired, and Sleepopolis; best mattress for couples by Oprah Daily; and one of the most trusted brands of 2026 by USA Today. With Helix, there’s a specific mattress to meet each and every body’s unique comfort needs. Just take their quiz—only two minutes to complete—that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They’ll even pick it up from you if you don’t love it. And now, Helix is offering listeners 27% off sitewide for a limited time at HelixSleep.com/Tim.

                                                                                                                                                                                                                  The post Tim’s Founder Kitchen — From Brainstorm to the President’s Office in Two Months (Featuring Jake Becraft, Strand Therapeutics) (#868) appeared first on The Blog of Author Tim Ferriss.

                                                                                                                                                                                                                  2 hr 16 min
                                                                                                                                                                                                                • Sami Inkinen of Virta Health — Reversing Type 2 Diabetes, Rowing 2,750 Miles, and Lessons from Fixing Metabolic Health in 100,000+ People (#866)

                                                                                                                                                                                                                  Sami Inkinen (@samiinkinen) is a Finnish-born, Stanford-trained entrepreneur and the founder and CEO/president of Trulia and Virta Health. Virta is on a mission to reverse metabolic disease in one billion people using technology, AI, and nutrition. Previously, Sami held roles at Microsoft, Nokia, and McKinsey & Company, after starting his career at a nuclear power plant in Finland. Sami holds an MS in engineering physics from the Helsinki University of Technology and an MBA from Stanford University.

                                                                                                                                                                                                                  A world-class endurance athlete, Sami is a triathlon age-group world champion and an 8-hour, 24-minute Ironman finisher, having completed the Hawaii Ironman World Championship seven times.

                                                                                                                                                                                                                  Sami also founded Fat Chance Row to raise awareness of the dangers of sugar and its connection to diabetes, rowing 2,750 miles from California to Hawaii with his wife—completely unsupported—while breaking a world record in the process.

                                                                                                                                                                                                                  Please enjoy!

                                                                                                                                                                                                                  The content of this episode is for informational purposes only. Neither Sami Inkinen nor Tim Ferriss is a medical professional, and nothing discussed here should be taken as medical advice or a substitute for consultation with a qualified healthcare provider.

                                                                                                                                                                                                                  This episode is brought to you by:

                                                                                                                                                                                                                  • Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim
                                                                                                                                                                                                                  • AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim
                                                                                                                                                                                                                  • Wealthfront high-yield cash account: Wealthfront.com/Tim 
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                                                                                                                                                                                                                    Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                                                                                                                                                                    Transcripts
                                                                                                                                                                                                                    • This episode
                                                                                                                                                                                                                    • All episodes
                                                                                                                                                                                                                    • SELECTED LINKS FROM THE EPISODE
                                                                                                                                                                                                                      • Connect with Sami Inkinen:
                                                                                                                                                                                                                      • Website | LinkedIn | Instagram | Twitter

                                                                                                                                                                                                                        Companies, Products, and Tools
                                                                                                                                                                                                                        • Virta Health
                                                                                                                                                                                                                        • Abbott Precision Xtra Blood Glucose/Ketone meter
                                                                                                                                                                                                                        • ChatGPT (OpenAI)
                                                                                                                                                                                                                        • Costco
                                                                                                                                                                                                                        • DEXA Body Composition Scan
                                                                                                                                                                                                                        • Erewhon
                                                                                                                                                                                                                        • Ford Escape
                                                                                                                                                                                                                        • Iridium Satellite Phones
                                                                                                                                                                                                                        • Keto-Mojo Blood Glucose/Ketone meter
                                                                                                                                                                                                                        • KetoAir Breath Ketone Device
                                                                                                                                                                                                                        • McDonald’s
                                                                                                                                                                                                                        • Mellow Johnny’s Bike Shop (Austin)
                                                                                                                                                                                                                        • Starlink
                                                                                                                                                                                                                        • Thrifty Car Rental
                                                                                                                                                                                                                        • Trulia
                                                                                                                                                                                                                        • US Foods
                                                                                                                                                                                                                        • Whole Foods Market
                                                                                                                                                                                                                        • Young Presidents’ Organization (YPO)
                                                                                                                                                                                                                        • Sami Inkinen’s Writing
                                                                                                                                                                                                                          • “Hacking Your Run: 10% Faster in Four Weeks“
                                                                                                                                                                                                                          • “Top 5 Tips: Getting and Staying in Shape for Busy Business People“
                                                                                                                                                                                                                          • “Zero Miles to Go, Divorce Papers Still Untouched” (Fat Chance Row: 2014 California-to-Hawaii)
                                                                                                                                                                                                                          • Books
                                                                                                                                                                                                                            • The 4-Hour Body: An Uncommon Guide to Rapid Fat-Loss, Incredible Sex, and Becoming Superhuman by Timothy Ferriss
                                                                                                                                                                                                                            • The 4-Hour Workweek: Escape 9-5, Live Anywhere, and Join the New Rich by Timothy Ferriss
                                                                                                                                                                                                                            • High Growth Handbook: Scaling Startups from 10 to 10,000 People by Elad Gil
                                                                                                                                                                                                                            • High Output Management by Andrew S. Grove
                                                                                                                                                                                                                            • The Score Takes Care of Itself: My Philosophy of Leadership by Bill Walsh
                                                                                                                                                                                                                            • Trejo: My Life of Crime, Redemption, and Hollywood by Danny Trejo with Donal Logue
                                                                                                                                                                                                                            • People
                                                                                                                                                                                                                              • Dominic D’Agostino 
                                                                                                                                                                                                                              • Elad Gil
                                                                                                                                                                                                                              • Andy  Grove
                                                                                                                                                                                                                              • Robert Rodriguez
                                                                                                                                                                                                                              • Danny Trejo
                                                                                                                                                                                                                              • Bill Walsh
                                                                                                                                                                                                                              • Tommy Wood
                                                                                                                                                                                                                              • Concepts, Protocols, and Drugs Referenced
                                                                                                                                                                                                                                • Area Deprivation Index (ADI)
                                                                                                                                                                                                                                • Fen-Phen
                                                                                                                                                                                                                                • GLP-1 Receptor Agonists (Ozempic, etc.)
                                                                                                                                                                                                                                • Löyly
                                                                                                                                                                                                                                • MASH / MASLD
                                                                                                                                                                                                                                • The Norwegian 4×4 Interval Protocol
                                                                                                                                                                                                                                • Rezdiffra (Resmetirom) by Madrigal Pharmaceuticals
                                                                                                                                                                                                                                • Type 2 Diabetes
                                                                                                                                                                                                                                • VO2 Max
                                                                                                                                                                                                                                • Places, Institutions, and Events
                                                                                                                                                                                                                                  • Helsinki University of Technology (Now Aalto University)
                                                                                                                                                                                                                                  • IRONMAN World Championship (Kona)
                                                                                                                                                                                                                                  • McKinsey & Company
                                                                                                                                                                                                                                  • Microsoft
                                                                                                                                                                                                                                  • Nokia
                                                                                                                                                                                                                                  • Sports Science Institute of South Africa
                                                                                                                                                                                                                                  • Stanford Graduate School of Business
                                                                                                                                                                                                                                  • Wildflower Triathlon
                                                                                                                                                                                                                                  • Timestamps
                                                                                                                                                                                                                                    • [00:00] Start.
                                                                                                                                                                                                                                    • [01:45] How Sami uses 15 minutes every Sunday to outrun the universe.
                                                                                                                                                                                                                                    • [03:37] Virta: at a thousand employees and counting.
                                                                                                                                                                                                                                    • [04:15] The 5 a.m. boot-up: cold lake, core work, and emptying the dishwasher.
                                                                                                                                                                                                                                    • [06:45] Why mood follows movement before the brain even boots up.
                                                                                                                                                                                                                                    • [11:54] Saying no to 99% of what “normal people” do.
                                                                                                                                                                                                                                    • [19:29] The weekly architecture.
                                                                                                                                                                                                                                    • [20:29] Two direct reports: the case for radical subtraction.
                                                                                                                                                                                                                                    • [21:09] 553 CEO letters and the case for one scalable habit.
                                                                                                                                                                                                                                    • [32:36] The text-file life plan.
                                                                                                                                                                                                                                    • [33:32] The 15-year personal plan Sami stumbled into by accident.
                                                                                                                                                                                                                                    • [34:30] The four-pillar formula for not cracking in 26 years of founder life.
                                                                                                                                                                                                                                    • [38:20] What “white Japanese people” and beer steins in saunas have in common.
                                                                                                                                                                                                                                    • [45:55] Smoke saunas, löyly, and the one Finnish word worth knowing.
                                                                                                                                                                                                                                    • [48:37] The lean, ten-percent-body-fat triathlete who was quietly going prediabetic.
                                                                                                                                                                                                                                    • [53:07] Why 93% of American adults are metabolically unhealthy.
                                                                                                                                                                                                                                    • [56:05] Reversing type 2 diabetes the way Virta actually does it.
                                                                                                                                                                                                                                    • [1:00:17] Most surprising interventions.
                                                                                                                                                                                                                                    • [1:03:32] The pancreatic cancer trial that bought patients 35% more time.
                                                                                                                                                                                                                                    • [1:07:02] The McDonald’s protocol: how to reverse diabetes from the drive-thru.
                                                                                                                                                                                                                                    • [1:16:00] Why GLP-1 adherence collapses and Virta’s doesn’t.
                                                                                                                                                                                                                                    • [1:21:10] Vegans, tofu, and the hardest macronutrient to get right.
                                                                                                                                                                                                                                    • [1:25:27] The dose-response curve that lets perfect stop being the enemy of progress.
                                                                                                                                                                                                                                    • [1:29:32] VO2 max blocks: how Sami trains an 80+ engine without burning out.
                                                                                                                                                                                                                                    • [1:41:56] Hacking 10% off your running speed in four weeks.
                                                                                                                                                                                                                                    • [1:46:09] Progressive overload, specificity, and the case against the long ride.
                                                                                                                                                                                                                                    • [1:50:07] 45 days, three hours, and a contract to keep a marriage afloat.
                                                                                                                                                                                                                                    • [1:55:27] The lightning strike in the middle of the Pacific that started a family.
                                                                                                                                                                                                                                    • [2:01:15] The 36-year-old who bought his first car only because his wife made him.
                                                                                                                                                                                                                                    • [2:05:40] The book recommendation no one saw coming: Trejo.
                                                                                                                                                                                                                                    • [2:07:51] The PSA: chronic, progressive, and irreversible — three words Sami refuses.
                                                                                                                                                                                                                                    • [2:11:40] Parting thoughts.
                                                                                                                                                                                                                                    • SAMI INKINEN QUOTES FROM THE INTERVIEW

                                                                                                                                                                                                                                      “Structure allows flexibility and spontaneity.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “Mood follows movement and motion.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “The biggest secret is saying no to 99 percent of the things that many people consider ‘normal’ so what you care [about] gets done.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “Truck drivers, their concept of a lunch is McDonald’s. We can’t tell them, ‘Oh, here’s the list. Go shop Whole Foods or Erewhon, and then go home and cook at home.’ It’s like, ‘Okay, McDonald’s it is. We’re going to reverse your diabetes on McDonald’s diet.’ And by the way, we do that.“

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “The adherence of Virta patients, again, which are real Americans, not Samis, real Americans, is twice as high at one year as taking a GLP-1 drug. We have 83 percent adherence retention of patients at one year. And look at any of the publicly available data: people stick to GLP-1s like 40 percent, maybe 50 percent, 30 to 50 percent.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “GLP-1s 100 percent affect your appetite. They change how much you eat, so you eat less, but they alone don’t change what you eat. … And if you don’t change what you eat, you’re not going to be perfectly or even optimally metabolically healthy.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “Type 2 diabetes can be reversed systematically, not miraculously. And so hopefully I can be a messenger of hope that these conditions are reversible, especially after I already disclosed that I used to live thinking it’s your fault, it’s your fault, you are just lazy, you don’t have the willpower. But that’s not true. Nobody gets these things because they’re lazy or they decide. It’s because of our food environment. And the food environment kind of slowly but surely poisons us. But if you know a few little tricks and changes, you can actually turn back the clock.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      “The love language of American capitalism is dollars. And so when you can help someone else to make money, you’re going to be very, very successful.”

                                                                                                                                                                                                                                      — Sami Inkinen

                                                                                                                                                                                                                                      This episode is brought to you by Eight Sleep. Temperature is one of the main causes of poor sleep, and heat is my personal nemesis. But a few years ago, I started using the Pod Cover, and it has transformed my sleep. Eight Sleep has launched their newest generation of the Pod: Pod 5 Ultra. It cools, it heats, and now it elevates, automatically. With the best temperature performance to date, Pod 5 Ultra ensures you and your partner stay cool in the heat and cozy warm in the cold. And now, listeners of The Tim Ferriss Show can get $350 off of the Pod 5 Ultra for a limited time! Click here to claim this deal and unlock your full potential through optimal sleep.

                                                                                                                                                                                                                                      This episode is brought to you by AG1. I’ve taken AG1 for more than a decade. Longtime listeners have heard me call it my nutritional insurance. Here’s the news: they’ve just launched AG1 Pro, designed for people focused on performance and longevity. I’ll be traveling soon, and I’m throwing this in my bag to cover my bases while I travel. Past a certain age, maintaining lean muscle becomes priority number one, and AG1 Pro is formulated to support exactly that. It includes HMB, a clinically studied compound that supports protein synthesis and helps reduce protein breakdown, plus zinc carnosine to support the gut lining. Remember: training is only half the equation. Recovery is where the work compounds, and AG1 Pro is built to support it. It’s NSF Certified for Sport, so what’s on the label is what’s in the pouch. Get your free AG1 Pro Yeti Shaker in the Welcome Kit at Drinkag1.com/Tim.

                                                                                                                                                                                                                                      This episode is brought to you by Wealthfront! Wealthfront is a financial services platform that offers services to help you save and invest your money. Right now, your cash can earn 3.30% APY—that’s the Annual Percentage Yield—with the Wealthfront Cash Account from its network of program banks. That’s 8 times more interest than a typical savings account at a bank, according to FDIC.gov as of 05/18/2026 (Wealthfront’s 3.30% APY vs. 0.38% average savings rate). Right now, for a limited time, Wealthfront is offering new clients that use my sign-up link an additional 0.75% boost over the base rate for three months, meaning you can get up to 4.05% APY, limited to a $150,000 balance. Terms & Conditions apply. Visit Wealthfront.com/Tim to get started. 

                                                                                                                                                                                                                                      The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC (“Wealthfront Brokerage”), member FINRA/SIPC. Wealthfront Brokerage is not a bank. The 3.30% Base APY on cash deposits is as of January 30, 2026, is representative, subject to change, and requires no minimum balance. Wealthfront Brokerage sweeps cash balances to Program Banks, where it earns the variable base APY. The Direct Deposit Plus Investing Program from Wealthfront Advisers LLC and Wealthfront Brokerage LLC provides eligible clients a 0.25% APY increase above the base APY on eligible Cash Account balances (up to an overall boosted rate of 4.30% for a limited time when including the three month 0.75% APY boost for new Cash Account clients) when you direct deposit $1,000/month plus maintain a funded investing account. Wealthfront may change or end the program at any time and determine eligibility at its discretion. Terms and conditions apply. Full details for both promotions at wealthfront.com/promo-terms.

                                                                                                                                                                                                                                      Tim Ferriss, who is not a client, receives cash compensation from Wealthfront Brokerage LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage LLC, which creates an incentive that results in a conflict of interest. Tim expresses his own opinions and Wealthfront does not endorse, sponsor, or promote them. This ad may not reflect the experience of other Cash Account clients, and similar outcomes are not guaranteed. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value. See full disclosures here. 

                                                                                                                                                                                                                                      Want to hear another conversation about ketones, metabolic health, and what your devices might be missing? Listen to my conversation with ketogenic-diet researcher Dr. Dominic D’Agostino, in which we discussed the ketone measurement paradox of feeling sharp at low readings, the carburetor analogy for ketone production versus utilization, metabolic memory and becoming more fat-adapted over time, my 18-day keto experiment, intermittent fasting as a keto on-ramp, the glucose-ketone index sweet spot, post-meal walking and GLUT4 activation, one-week-per-month protocols, low-carb Mediterranean as the 80/20 minimum effective dose, and much more.

                                                                                                                                                                                                                                      The post Sami Inkinen of Virta Health — Reversing Type 2 Diabetes, Rowing 2,750 Miles, and Lessons from Fixing Metabolic Health in 100,000+ People (#866) appeared first on The Blog of Author Tim Ferriss.

                                                                                                                                                                                                                                      2 hr 20 min
                                                                                                                                                                                                                                    • The Most Incredible Transformation I’ve Ever Seen — Jerzy Gregorek on Autism, Cerebral Palsy, Coaching, and the Power of Micro-Progressions (#865)

                                                                                                                                                                                                                                      Jerzy Gregorek (@TheHappyBody) is a 4x World Weightlifting Champion, co-founder of UCLA’s weightlifting team, and co-creator, with his wife Aniela, of the Happy Body program. 

                                                                                                                                                                                                                                      To fill out the form on Cerebral Palsy Research Project, visit tim.blog/cp.

                                                                                                                                                                                                                                      To watch Prisoner No More for free, click here.

                                                                                                                                                                                                                                      Please enjoy!

                                                                                                                                                                                                                                      This episode is brought to you by:

                                                                                                                                                                                                                                      • Matic, the intelligent robot vacuum and mop that navigates obstacles and needs no babysitting: MaticRobots.com/Tim
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                                                                                                                                                                                                                                        Listen to this episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Castbox, YouTube Music, Amazon Music, Audible, or on your favorite podcast platform.

                                                                                                                                                                                                                                        Transcripts
                                                                                                                                                                                                                                        • This episode
                                                                                                                                                                                                                                        • All episodes
                                                                                                                                                                                                                                        • SELECTED LINKS FROM THE EPISODE
                                                                                                                                                                                                                                          • Connect with Jerzy Gregorek:
                                                                                                                                                                                                                                          • The Happy Body | YouTube

                                                                                                                                                                                                                                            • Jerzy’s Previous Appearance:
                                                                                                                                                                                                                                              • The Lion of Olympic Weightlifting, 62-Year-Old Jerzy Gregorek (Also Featuring: Naval Ravikant) | The Tim Ferriss Show #228
                                                                                                                                                                                                                                              • Films & Documentaries
                                                                                                                                                                                                                                                • Prisoner, No More
                                                                                                                                                                                                                                                • Programs
                                                                                                                                                                                                                                                  • The Happy Body Program
                                                                                                                                                                                                                                                  • Cerebral Palsy Research Project Form
                                                                                                                                                                                                                                                  • Books
                                                                                                                                                                                                                                                    • The Happy Body: The Simple Science of Nutrition, Exercise, and Relaxation by Aniela & Jerzy Gregorek
                                                                                                                                                                                                                                                    • People
                                                                                                                                                                                                                                                      • Aniela Gregorek
                                                                                                                                                                                                                                                      • Genghis Khan
                                                                                                                                                                                                                                                      • Tae Jin Park
                                                                                                                                                                                                                                                      • Naval Ravikant
                                                                                                                                                                                                                                                      • Jeff Wolfe
                                                                                                                                                                                                                                                      • Admiral Yi Sun-Sin
                                                                                                                                                                                                                                                      • Places
                                                                                                                                                                                                                                                        • San Jose State University
                                                                                                                                                                                                                                                        • UCLA
                                                                                                                                                                                                                                                        • Concepts
                                                                                                                                                                                                                                                          • Autism Spectrum Disorder
                                                                                                                                                                                                                                                          • Battle of Myeongnyang (1597)
                                                                                                                                                                                                                                                          • Cerebral Palsy
                                                                                                                                                                                                                                                          • Exploring Autism Through Poetry
                                                                                                                                                                                                                                                          • Exercise Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
                                                                                                                                                                                                                                                          • Exercise Therapy for Fibromyalgia
                                                                                                                                                                                                                                                          • How to Use Micro-Progressions in the Gym
                                                                                                                                                                                                                                                          • The Myth of “No Pain, No Gain”
                                                                                                                                                                                                                                                          • Neuroplasticity of Brain Networks Through Exercise
                                                                                                                                                                                                                                                          • Weightlifting and Poetry
                                                                                                                                                                                                                                                          • Timestamps
                                                                                                                                                                                                                                                            • [00:00:00] Start.
                                                                                                                                                                                                                                                            • [00:01:29] The transformation I’ve been chasing for a decade.
                                                                                                                                                                                                                                                            • [00:02:39] When an unstoppable coach meets an immovable cerebral palsy diagnosis.
                                                                                                                                                                                                                                                            • [00:04:35] Three pounds to 170: the bench press that woke a brain up.
                                                                                                                                                                                                                                                            • [00:07:17] Navigating autism and building the basics of communication that sustain higher education.
                                                                                                                                                                                                                                                            • [00:10:41] Treadmills exhaust, athletes progress: why physical therapy stalled where coaching took off.
                                                                                                                                                                                                                                                            • [00:19:00] Lethargy, sleeping in the car, and the quiet power of resting energy.
                                                                                                                                                                                                                                                            • [00:20:22] The 16-inch box that opened the bathroom door — and everything after.
                                                                                                                                                                                                                                                            • [00:24:26] Micro-progressions, certificates, ceremonies, and writing history onto a blank brain.
                                                                                                                                                                                                                                                            • [00:29:16] Parental dedication and appreciation.
                                                                                                                                                                                                                                                            • [00:31:54] The adulthood gambit: quit piano, quit training — if you can stick an 18-inch jump.
                                                                                                                                                                                                                                                            • [00:35:14] License plates as the gateway drug from counting to math five hours a day.
                                                                                                                                                                                                                                                            • [00:40:04] Jerzy’s coaching style doesn’t court approval.
                                                                                                                                                                                                                                                            • [00:42:42] Genghis Khan vs. Admiral Yi Sun-Sin vs. Jerzy vs. Tae Jin.
                                                                                                                                                                                                                                                            • [00:46:35] In search of the science behind such transformations: 25 patients, five years, and a method built to be replicated (interested researchers, visit tim.blog/cp).
                                                                                                                                                                                                                                                            • [01:05:39] Hard choices, easy life — and the call to find your starting point.
                                                                                                                                                                                                                                                            • JERZY GREGOREK QUOTES FROM THE INTERVIEW

                                                                                                                                                                                                                                                              “I believe that everybody can improve. So it really doesn’t matter for me [if it’s] cerebral palsy or not. If it’s chronic fatigue, it can happen. If it’s fibromyalgia, the progress can happen.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “[If] we exercise without mission or purpose or goals, we can exercise for 10 years and never change.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “With cerebral palsy, I think that the focus is not athletic focus. The focus is to comfort them. So not really improve them … just to comfort them so they have the safe life and they are okay, I guess. That’s probably the difference here.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “I saw the connection between the squat, the bench, the numbers, the words, the beliefs, and philosophy. I saw connections everywhere, and I created the challenges, the hard choices, every time, everywhere. For me, bench pressing, going from 100 pounds to 102 was not different than knowing what is 15 plus 17.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “With cerebral palsy, they have different conditions, different beginnings. The most important [thing] is to find where is the beginning. Where to start is one of the major things because usually I think that we want too much. It’s not going to happen. So we need to find this very tiny thing.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “We have to remember that we are facilitators. We are not really cultures that created the powerful human being. That powerful human being actually created themselves. And we have to create a place where it’s athletically aligned with athleticism and not care only.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              “[Tae Jin’s father and mother] were worrying all the time what will happen if they die, what will happen if something happened to them. Now they don’t have to worry anymore. Tae Jin is completely independent. He’s in college, for Christ’s sake! Just imagine that. And a lot of that, I believe, 100 percent, that can happen with everyone.”

                                                                                                                                                                                                                                                              — Jerzy Gregorek

                                                                                                                                                                                                                                                              This episode is brought to you by Our Place’s Titanium Always Pan® Pro. Many nonstick pans can release harmful “forever chemicals”—PFAS—into your food, your home, and, ultimately, your body. Teflon is a prime example—it is *the* forever chemical that most companies are still using. Exposure to PFAS has been linked to major health issues like gut microbiome disruption, testosterone dysregulation, and more, which have been correlated to chronic disease in the long term. This is why I use the Titanium Always Pan Pro from today’s sponsor, Our Place.  It’s the first nonstick pan with zero coating. This means zero “forever chemicals” and a durability that will last a lifetime. That’s right—no degradation over time like traditional nonstick pans.

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                                                                                                                                                                                                                                                              This episode is brought to you by Matic! Readers of The 4-Hour Workweek know I love automation. Anywhere I can “set it and forget it” is a win and gives me more time for the things I enjoy. That’s why I’m such a fan of Matic. As their tagline goes, “the world’s most advanced floor cleaner.” Matic learns your home and runs quietly in the background. It vacuums, mops, docks itself, and doesn’t strangle itself on charging cables or get wedged under your couch. I put out a note on social asking how people liked it, and the response was overwhelmingly positive.

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                                                                                                                                                                                                                                                              Want to hear the last time Jerzy was on the show? Listen to our conversation in which we discussed immigrating from Poland as a political refugee, the importance of flexibility, strength, speed, and posture at any age, winning in small increments, how an accidental introduction to weightlifting reclaimed Jerzy from three years of blackout alcoholism, The Happy Body program, the rusty hinge analogy, the three killers of happiness (sarcasm, complaining, and blaming), poetry as medicine for those who struggle with weight loss, Plato’s chariot allegory, and much more.

                                                                                                                                                                                                                                                              The post The Most Incredible Transformation I’ve Ever Seen — Jerzy Gregorek on Autism, Cerebral Palsy, Coaching, and the Power of Micro-Progressions (#865) appeared first on The Blog of Author Tim Ferriss.

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                                                                                                                                                                                                                                                            About The Tim Ferriss Show Archives - The Blog of Author Tim Ferriss

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                                                                                                                                                                                                                                                            Tim Ferriss is the author of five #1 New York Times bestsellers and host of The Tim Ferriss Show podcast.