Dr. Carl Wittwer, inventor LightCycler™, is a well-recognized name in clinical laboratory diagnostics. In this interview, he describes what drove him to push the limits of PCR beyond the biotechnology industry of its time. His own invention story reflects what Thomas Edison once said about this process: It’s 1 percent inspiration, 99 percent perspiration. Dr. Wittwer shares his vision of how environment, people, and organizational policies all contribute to fostering entrepreneurial innovation.