The Upstarts Podcast

You probably haven’t heard of AI startup founder Zoë Weil. But if you’ve recently hunted for furniture at Wayfair or booked a trip on Priceline, you’ve likely been influenced by her handiwork.

Her $1.4 billion startup, Sequen, is building what it calls the ranking intelligence layer of the internet. Go browse a retail site optimized by Sequen, and you won’t see the same layout twice. But that reordering is subtle enough – and, Weil believes, helpful enough – that you won’t even notice, let alone mind.

Fewer than 100 people in the world can do this work, Weil says, and in just two years, Sequen has hired nine of them. It’s now making customers billions of dollars in boosted sales, she adds, turning public-company CTOs into her best marketing via word of mouth. But Weil has a bigger ambition: replace the online cookie.

On The Upstarts Podcast, Sequen’s CEO talks about why its AI engine doesn’t depend on large language models; why she insists that influencing shoppers is good for them; and how Sequen convinced one key hire to walk away from a nine-figure job.

Plus, she shares her Upstart Moment: getting a foot in the door as a four-person startup when the customer’s own, much larger data science team wanted her gone.

Chapters:

00:00 Introduction

Zoë's LinkedIn: https://www.linkedin.com/in/zoefrancesweil/

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

Ramp is best known for its corporate cards. Or maybe its marketing stunts with the likes of Kevin from ‘The Office,’ Tony Hawk and a 70-minute Broadway musical about paying bills.

But co-CEO Eric Glyman says his $60 billion startup, New York’s most valuable, feels less like a fintech and more like a productivity company driven by one simple question: If a business spends $100 to make $200, how can Ramp improve that ratio?

That obsession helps explain why Ramp keeps shipping products like Glass and Inspect that move it further from its corporate credit card roots. Nearly 100,000 companies trust Ramp today for everything from expenses to procurement and AI spend. When Glyman zooms out, he sees the millions of businesses that, stunts and all, still haven’t heard of it.

On The Upstarts Podcast, Glyman shares why he’d rather run Ramp like Amazon than Google; why Ramp hires for proof of work, not credentials, from a 14-year-old intern to a 28-year-old CTO; and how being the first customer for Anthropic’s Claude Code and Cognition’s Devin led Ramp to build its own AI tools.

Plus: A reunion with college classmate and Upstarts editor Alex Konrad to talk about what really happened to Paribus, Glyman’s first startup with co-founder Karim Atiyeh; what they learned at Capital One; and a warning for Instinct and Muse.

Chapters:

00:00 Introduction

Eric's LinkedIn: https://www.linkedin.com/in/eglyman/

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

The tech industry has an AI scaling problem, and SF Compute CEO Evan Conrad says it all comes down to one thing: credit.

Lenders don’t want to underwrite risky AI labs and startups, forcing them to raise at ever-higher valuations to be able to pay hefty deposits upfront. And when capacity does free up, the little guy often gets cut out, as the industry’s biggest players lock up ever more horsepower.

Conrad’s startup thinks it can change the equation. Founded out of necessity when his first AI lab faced a $400K monthly compute bill it couldn’t cover, SF Compute now operates GPU clusters for their owners, while helping ensure a fair market for their buyers, by running what Conrad calls the only “physically settled compute market.” SF Compute recently signed a deal worth $245 million – a drop in the bucket compared to his vision in a fast-growing, little-understood market behind the AI boom.

On The Upstarts Podcast, Conrad talks about why credit, not land or power, is AI’s true bottleneck; why upfront compute costs are driving eye-popping valuations from VCs; and why data centers could become geopolitical bargaining chips.

Plus, he shares his Upstart Moment: pitching early investors on a new “power grid” for AI they just couldn’t understand.

Chapters:

00:00 Introduction

Evan's LinkedIn: https://www.linkedin.com/in/evan-conrad/

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

If you’ve parked a car recently in the U.S. or Canada, there’s a good chance you paid through a startup called Metropolis. Founded in 2017 by CEO Alex Israel and three co-founders in a Santa Monica garage, Metropolis is now the largest parking operator in North America – with 23,000 employees, $5 billion in payments, and 30 million Americans signed up for its ticketless app.

If that sounds unusual for a startup, you’re right. Metropolis got there in unusual fashion, enlisting the help of billionaire Todd Boehly to acquire a legacy player many times its size in a move one banker initially dismissed as “dog catches 747.”

But its CEO doesn’t really see Metropolis as just a parking company. He calls it an applied AI company, one piloting a new “recognition economy” that cuts the wait out of experiences for consumers, from drive-throughs to hotel lobbies.

On The Upstarts Podcast, Israel talks about why merging “ugly, unsexy” businesses with AI has suddenly gained popularity; why Metropolis is all-in on autonomous vehicles, robotaxis, and drones; and why he argues the startup’s opt-in approach avoids the privacy concerns facing surveillance startups.

Plus, he shares his Upstart Moment: Inviting the CEO of his bigger competitor to a seafood buffet to inform him that he planned to take their company private.

Chapters:

00:00 Introduction

Alex's LinkedIn: https://www.linkedin.com/in/alex-israel/?isSelfProfile=false

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

Neko Health CEO Hjalmar Nilsonne calls it the most valuable hour you can spend on your health. Since opening its first U.S. location in New York last month, more than 50,000 people have joined the waitlist – for one clinic alone.

Co-founded in 2018 with Spotify’s Daniel Ek and valued at $7 billion, Neko offers one-hour scans that map your skin, heart and blood for $499. A clinician then walks you through the results before you leave, complete with a futuristic 3D scan. Already in operation in the U.K. and Sweden, Neko’s now expanding across America, with Miami, Washington, D.C. and San Francisco coming next.

On The Upstarts Podcast, Nilsonne talks about the fateful Twitter DM from Ek that got Neko going; why the doctor visit hasn’t changed much in 100 years; and how to keep a startup team motivated while chasing a long-term “moonshot.”

Plus, he shares his Upstart Moment: a bet-the-company pivot driven by an internal memo he wrote, “Free Is Not Enough.”

Chapters:

00:00 Introduction

Hjalmar's LinkedIn: https://www.linkedin.com/in/nilsonne?originalSubdomain=se

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

Founder Ben Lamm has found success building startups in gaming, SaaS and AI. But the boldest — and biggest — bet of his career is Colossal Biosciences, a biotech venture working to bring back extinct species like the dire wolf, dodo, Tasmanian tiger and woolly mammoth.

It's a decades-long endeavor so crazy that one investor warned Lamm it would "completely ruin" his career. But so far, it's working. Founded in 2021 by Lamm and famed Harvard geneticist George Church, Colossal has already cloned and raised three dire wolves in a secret location, created woolly mice, and reportedly held talks to raise at a valuation of $23 billion or more.

Still, Lamm faces some basic, persistent questions: Why do all this? And isn't this like Jurassic Park?

On The Upstarts Podcast, Lamm talks about why Colossal made reviving the mammoth its North Star; why building in biology is so different from software; and why he won't consider anything short of reviving every targeted species a success.

Plus: Why Lamm insists Colossal won't bring back the dinosaurs.

Chapters:

00:00 Introduction

Colossal Biosciences: https://colossal.com/

For more, visit https://www.upstartsmedia.com/

Season 3 of the Upstarts Podcast is presented by ⁠⁠⁠Jira by Atlassian: https://www.atlassian.com/software/jira

Produced & edited by Eric Johnson from LightningPod: https://lightningpod.fm/

A crisis is happening in accounting that goes far beyond creative bookkeeping or lost receipts: we don't have enough people.

Enough work exists for 30 million accountants to prepare tax returns and audits, restructure data and improve how companies organize. The U.S. has just 3 million, says Basis co-founder and CEO Matt Harpe. "The number is rapidly declining," he says.

Founded in 2023 by Harpe and co-founder Mitchell Troyanovsky, Basis builds AI agents to help. Operating behind the scenes, Basis agents learn a firm's best practices and then automate much of the process, allowing its staffers to review more work for clients. Basis reached a $1.15 billion valuation in February 2026.

Far from eliminating jobs, Harpe believes his startup will help those human accountants get paid more. "It will increase how valuable accountants are, because they will be able to accomplish so much more," he says.

On the Upstarts Podcast, Harpe talks about why Basis shunned a chatbot approach to go all-in on agents from the start; why outcome-based pricing is preferable, but not easily achieved; and how he pitches top AI talent in New York on building in accounting, of all things.

Plus, he shares his Upstart Moment: turning down short-term revenue by not charging for a product until their outcomes could match what they promised.

Chapters:

00:00 Introduction

Matt's LinkedIn

Basis

For more, visit https://www.upstartsmedia.com/

Season 2 of the Upstarts Podcast is presented by ⁠⁠⁠Rippling

Produced & edited by Eric Johnson from LightningPod

Doctors are burned out. Patients don’t understand the advice they’re given. And the U.S. healthcare system is drowning each year in $1.5 trillion – with a “T” – in administrative costs.

Abridge co-founder and CEO Shiv Rao thinks he can help. He’s seen the problem on both sides – as a practicing cardiologist who still sees patients, and as a partner who spent years navigating the system to seek fertility treatments with his spouse.

“We’d look at each other and be like, ‘What did they just say?’ And I’m a doctor,” he says.

Founded in Pittsburgh in 2018, Abridge is building what Rao calls the “AI operating system” for healthcare. Abridge’s software automates all the clerical work of a visit, from notes to billing, and increasingly assists with making clinical recommendations, too. Valued at $5.3 billion, Abridge serves more than 300 health systems, reaching 250 million Americans, and recently partnered with Eli Lilly and Nvidia.

But Abridge has faced an uphill journey from day one, when Rao convinced his former employer to take a chance on a fledgling startup. Microsoft’s a big player. Epic Systems looms, and a number of well-funded startups are chasing Abridge’s lead.

On The Upstarts Podcast, Rao talks about how an early bet on AI got Abridge going, before ChatGPT; why reaching scale in healthcare requires years of “eating glass” and “kissing frogs;” and why he thinks Abridge can help doctors and nurses feel like “superheroes.”

Plus, he shares his Upstart Moment: A “YOLO” decision to take on Microsoft head-to-head.

Chapters:

00:00 Introduction

Shiv's LinkedIn

Abridge

For more, visit https://www.upstartsmedia.com/

Season 2 of the Upstarts Podcast is presented by ⁠⁠⁠Rippling

Produced & edited by Eric Johnson from LightningPod

The world's big companies are blowing through their AI budgets. At French startup unicorn Pigment, Eléonore Crespo wants to help.

"Our CEO is pressuring us for everybody in the company to use AI, but we don't have any right way to think about it," Crespo says she hears chief financial officers complain. “It’s going to be a big topic for everyone, and it goes beyond just understanding your costs."

Pigment, founded by co-CEOs Crespo and Criteo veteran Romain Nicoli in 2019, fights runaway AI spending with AI. Its agents help CFOs and finance teams at customers like Anthropic, Notion, Coca-Cola and Unilever make faster, better financial decisions.

For analysts, Crespo argues her tools can free up much of the 80% of time they currently spend sifting through data; her (perhaps optimistic) hope is that they can then focus on higher-level decisions, without fearing for their jobs.

On The Upstarts Podcast, Crespo talks about how building in Paris helps Pigment compete; how a culture of “unreasonable hospitality” makes it win; and how careful communication makes a co-CEO setup work.

Plus, she shares her Upstart Moment: landing a key executive hire, with an in-person assist from the actor Tom Cruise.

Chapters:

00:00 Introduction

Eléonore's LinkedIn

Pigment

For more, visit https://www.upstartsmedia.com/

Season 2 of the Upstarts Podcast is presented by ⁠⁠⁠Rippling⁠⁠

Produced & edited by Eric Johnson from LightningPod

Materials science hasn’t changed much in 150 years. Radical AI CEO Joseph Krause wants to change that.

In a big new lab in Brooklyn’s Navy Yard, the startup founder is looking to change that. He’s building a “next-gen” approach that he says makes other autonomous labs look like hand-free driving mode on a car, compared to a fully self-driving Waymo.

It’s an approach that plenty of corporate scientists tell Krause must be too good to be true. “How could you really discover more alloys in a week than we have discovered in our company history?” he says they ask.

But since its founding in 2024, Radical AI has already produced valuable, and secret, alloys for customers, Krause insists. And the startup has done it after raising just $55 million in its last funding round, not the $1 billion of well-heeled competitors..

On the Upstarts Podcast, Krause explains how a SpaceX breakthrough helped kick off a category; why cloud labs and deep tech companies often fail; and why concurrent engineering is as important as next-gen lab equipment itself.

Plus, he shares his Upstart Moment: a 100-year-vision to become one of the world’s most important companies: “When we put a civilization on Mars, the habitat that they're living in will be made with Radical materials.”

Chapters:

00:00 Introduction

Joseph's LinkedIn

Radical AI

For more, visit https://www.upstartsmedia.com/

Season 2 of the Upstarts Podcast is presented by ⁠⁠⁠Rippling⁠⁠

Produced & edited by Eric Johnson from LightningPod