Real-world data show about one-quarter of lupus patients achieve six-month remission with anifrolumab, supporting earlier targeted therapy, steroid reduction, and evolving care pathways for systemic lupus erythematosus.

Research links sleep disruption to microglial activation, reframing insomnia as neuro-immune stress that may drive inflammation, cognitive fog, mood symptoms, and long-term brain vulnerability.

Long-term data from the ACTIVE trial suggest speed-based cognitive training with boosters may lower dementia risk, supporting scalable, nonpharmacologic prevention strategies for at-risk older adults.

FDA grants accelerated first-line approval to zongertinib, a selective oral HER2 TKI, redefining treatment for HER2-mutant metastatic NSCLC with high response rates and precision-first strategy.

FDA-cleared CTA software creates patient-specific 3D cardiac conduction maps for planning and live guidance, aiming to reduce conduction injury, pacing complications, and procedural uncertainty.

Gut microbiota and IgA shape vaccine effectiveness. Disrupted mucosal immunity may reduce response, guiding clinicians to evaluate nonresponse, personalize vaccination, and protect vulnerable populations.

Patient-centered integration of spirituality into substance use care can enhance prevention and recovery, provided boundaries, autonomy, and evidence-based treatments remain central to clinical decision making.

Emerging evidence links sleep disruption to microglial activation, connecting fragmented sleep with inflammation, cognitive impairment, mood symptoms, and potential long-term neurodegenerative vulnerability, reframing insomnia as neuro-immune stress.

COVID-19 mRNA vaccination near immunotherapy initiation may enhance cancer survival by reprogramming tumor immunity, potentially transforming “cold” tumors and reshaping oncology practice, policy, and research priorities.

Rising rheumatology article retractions, largely driven by misconduct, threaten evidence integrity, clinical decision making, patient safety, and trust in research guiding lifelong autoimmune disease treatment.