🧬 Regulação Humoral da Fome e Saciedade na Obesidade

As fontes discutem a regulação hormonal do peso corporal, com foco especial na leptina e no uso de modelagem matemática para compreender o metabolismo. O primeiro texto destaca como arquétipos computacionais, baseados em dados de camundongos, podem ser adaptados para criar um "humano virtual" e testar hipóteses sobre a homeostase energética. Já o segundo material detalha a fisiopatologia da obesidade, descrevendo como o tecido adiposo disfuncional altera a secreção de hormônios como grelina, adiponectina e peptídeo YY. Ambos os textos convergem na análise da resistência à leptina e no desequilíbrio entre os sinais de fome e saciedade. Essas pesquisas buscam integrar conhecimentos da biometria e endocrinologia para aprimorar tratamentos contra distúrbios metabólicos. Assim, as obras oferecem uma visão técnica sobre os mecanismos biológicos que controlam a ingestão de alimentos e o gasto de energia.

PIRES, Jorge Guerra. Fisiologia Matemática, Biologia Matemática, e Biomatemática: leptina e a busca pelo controle de peso. Revista Eletrônica Gestão & Saúde, [S. l.], v. 6, n. 3, p. 2982-2986, 2015. Disponível em: https://dialnet.unirioja.es/servlet/articulo?codigo=5555826. Acesso em: 17 jul. 2026

SILVA, Lyandra Dias da et al. Regulação Humoral da Fome e Saciedade na Obesidade. In: Aportes teóricos, prática e inovação em ciências da saúde. [S. l.]: Editora e-Publicar, 2022. cap. 41, p. 551-567

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View ORCID ProfileJorge Guerra Pires

doi: https://doi.org/10.1101/2023.12.31.23300681

https://www.medrxiv.org/content/10.1101/2023.12.31.23300681v2

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