The fight against antibiotic resistance is a fight against evolution, and sadly it's not a war we're ever going to win. Our approach so far has been to kill the bad bugs, waging a war on pathogens with antimicrobials, like vaccines, antivirals and antibiotics as our major weapons. So could there be a better way for managing pathogens, a way in which we can tolerate them better, and actually promote and induce tolerance in those that have been affected? Biologist Janelle Ayres of The Salk Institue in California is working on this alternative approach.