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This Week in Pediatric Oncology #103 - November 30, 2022

Join us as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Roger Packer from Children’s National Hospital in Washington DC. Dr. Packer is the Senior Vice President of the Center for Neurosciences and Behavioral Medicine at Children’s National, which is introducing a low-intensity focused ultrasound (LIFU) therapy. Listen in as Dr. Packer discusses what LIFU is and the exciting new techniques and technologies behind it.

To learn more, you can visit https://childrensnational.org/news-and-events/childrens-newsroom/2022/a-pediatric-brain-tumor-first-opening-the-blood-brain-barrier-to-deliver-targeted-therapies

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This Week in Pediatric Oncology #102 - November 10, 2022

Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined again by Dr. Douglas Hawkins - who is the current Chair of the Children’s Oncology Group (COG). They discuss in depth the findings of a presented published paper regarding the inequities of childhood cancer outcomes based on external socioeconomic factors such as neighborhood and household poverty.

To read the full paper, visit https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7936051&blobtype=pdf

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Tune in as our hosts, Dr. Tim Cripe & Dr. Brenda Weigel, are joined by Dr. Will Parsons who is the Co-Director of the Brain Tumor Program at Texas Children's Hospital in Houston, TX. In this episode, Dr. Parsons discusses the background & purpose behind the NCI Pediatric MATCH Trial, the current status of the trial itself, and how the data can be used to benefit investigations moving forward.

To learn more about the Pediatric MATCH Trial, you can go to https://childrensoncologygroup.org/pediatricmatch

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Happy 100th Episode to the This Week in Pediatric Oncology Podcast! In this special milestone episode, our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Scott Kennedy & Donna Ludwinski from Solving Kids' Cancer to reminisce on the history & creation of TWiPO and talk about their favorite podcast episodes from over the years.

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Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Samuel Volchenboum who is an Associate Professor of Pediatrics from the University of Chicago. Dr. Volchenboum spearheaded an international effort through two data platforms called the Pediatric Cancer Data Commons (PCDC) & GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes). Listen in as he explains the importance behind these two platforms, as well as the challenges and barriers to data collaboration.

To learn more about the Pediatric Cancer Data Commons, you can visit http://commons.cri.uchicago.edu

To learn more about GEARBOx, you can visit http://gearbox.pedscommons.org

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Listen in as our host, Dr. Timothy Cripe, is joined by Dr. Jonathan Finlay to discuss his acclaimed & reputable career within the pediatric cancer landscape. Dr. Finlay reflects on his distinguished journey including how he got into pediatric immunology, how the field has evolved throughout his medical career, his views on exciting technologies & strategies, and how his personal experience as a patient influenced his position and mindset as a physician.

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Listen in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Robbie Majzner - an Assistant Professor of Pediatrics in the Division of Hematology and Oncology at Stanford University's School of Medicine. Dr. Majzner goes into great detail about his recent clinical trial on GD2-CAR T cell therapy for H3K27M-mutated Diffuse Midline Gliomas - the findings, the process, and what the future holds. You can read more about Dr. Majzner's study here: https://www.nature.com/articles/s41586-022-04489-4

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Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors. 

Have any thoughts? Questions? Ideas for future topics? Email us at [email protected].

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Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids’ Cancer’s patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.

You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111

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In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments.

You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco

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