This Week in Startups is brought to you by…

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Today’s show: Jason and Lon Harris cover Nikola’s Chapter 11 and how founders can avoid the same mistake, Superhuman AI’s new features, Mira Murati’s Thinking Machines and where Sam Altman went wrong holding onto top talent, plus much more!

Timestamps:

(0:00) Episode teaser(1:26) Introduction to startup news and trends(2:47) Bill Ackman's J trade and Herbalife controversy(5:24) Comparing trading strategies: Jason vs. Pelosi(9:49) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist(11:29) HP's acquisition of Humane and its significance(13:52) Challenges facing the AI industry(20:30) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(21:47) OpenAI veterans launch a new venture(28:09) Chamath's venture into high stakes poker(29:35) Atlassian. Head to https://www.atlassian.com/software/startups to see if you qualify for 50 free seats for 12 months.(36:37) Nikola's Chapter 11 filing and securities fraud(48:10) The upside of failing as a founder in the U.S.(50:24) Superhuman introduces AI-powered email features(51:58) Preview of upcoming guests on the podcast(53:03) Key characteristics of successful founders(56:21) Play-along: Guess the fake startup(1:04:12) Movie trilogy rankings: Superman, Star Wars, Terminator

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Check out these past Guess The Fake Startups segments:

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https://www.youtube.com/watch?v=rhnOXuGnh14

https://www.youtube.com/watch?v=ueazpyGOgcc

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Great TWIST interviews: Will Guidara,Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta,Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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In today's episode: Jason and Alex break down one of the craziest crypto stories yet—a $100M meme coin meltdown, insider trading, and Argentina’s president caught in the middle. Coffeezilla joins the show to explain how meme coins are rigged, why Dave Portnoy got a $5M refund while everyone else got wrecked, and what really went down with the Libra token. Plus, we debate if crypto can be fixed or if the grift is too far gone.

Timestamps:

(0:00) Jason and Alex kick off the show.(2:17) Libra fiasco, crypto scams, and influencer involvement(4:42) The impact of meme coins on politics and ethical considerations(8:02) Trump's involvement in meme coins(10:10) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(11:30) The Libra coin scandal and its broader implications(18:39) Coffeezilla interview clip with Hayden Davis(20:20) Netsuite. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(21:46) Introduction to Pump.fun and discussion on token launching risks(23:21) Coffeezilla joins Alex and Jason!(24:10) Discussion on Argentinian president and Tech Forum Argentina(27:29) Examination of Hayden Davis and token manipulation(29:29) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial setup.(31:02) Analysis of the broken crypto system and regulatory issues(35:40) Intentional fraud, regulation, and meme coins in politics(41:21) Potential solutions and regulatory controls under new administration(50:23) Concerns and proposed framework for crypto regulation(54:52) Importance of regulation and combating crypto fraud(58:18) Coffeezilla's perspective on meme coins and future regulations(1:01:22) Advice to potential crypto investors and FTC news implications(1:02:08) Impact of regulation on American innovation and tech giants' growth(1:05:03) Current administration's stance on business combinations(1:06:10) Arguments against large companies acquiring competitors(1:07:23) Risks and potential benefits of hypothetical acquisitions(1:08:29) Debate on market competition dynamics

*

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Thank you to our partners:

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Great TWIST interviews: Will Guidara,Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta,Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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Today’s show: IPO shakeups, big AI moves, and essential founder hacks—this episode covers it all. Jason breaks down Robinhood’s 6X stock surge and his strategy for $HOOD, plus the latest on tech IPOs as Turo pulls out and SailPoint surges. We dive into AI’s open-source battle, with X.ai chasing a $10B raise and DeepSeek challenging Hugging Face. And for founders, Jason shares the startup golden rule you should break for success—plus, a brand-new startup idea he’s willing to fund right now.

*

Timestamps:

(0:00) Jason and Alex kick off the show.(1:51) The ‘new’ news cycle(2:17) Calming down during chaotic times(4:29) IPO updates: Turo and SailPoint, private equity, public markets, and M&A(9:37) Rental car business & sharing economy job creation

(9:53) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(12:21) Robinhood's financial performance & fintech resurgence(18:08) NVIDIA's investment in WeRide & self-driving technology(20:02) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period.

(21:28) Cooking, convenience, DoorDash, Uber, CloudKitchens & startup opportunities(25:45) Smart IoT devices & revisiting the mobile convenience stores idea(29:59) Lemon.io . Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(33:12) XAI's potential funding & AI's impact on consumer behavior(40:49) Revisiting failed startup ideas & founder hacks(47:18) Customer advisory councils: size, incentives, and roles(52:09) Humanoid robots & market competition in the next decade(58:51) OpenAI model selection & user experience(1:00:56) Founder University pitches compilation(1:13:56) Audience question: Addressing criticism on Trump and Elon Musk(1:17:26) Discussion on Palantir, bias, state of journalism, and investigative reporting

*

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Thank you to our partners:

(9:53) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(20:02) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period.

(29:59) Lemon.io . Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist*

Great TWIST interviews: Will Guidara,Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta,Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

*

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

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This Week in Startups is brought to you by…

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Today’s show: Jason and Alex cover…TBD

Timestamps:

(0:00) Episode Teaser(1:16) Welcome Alex Wilhelm & Sam Lessin; Slow Ventures Creator Fund(3:49) Significance of the $60M creator-focused fund(5:47) Community-building and product development strategy(7:02) Mr. Beast's success as a case study(9:41) Vanta. Get $1000 off your SOC 2 athttps://www.vanta.com/twist(11:17) Financial structures and strategies in creator investments(14:14) Addressing challenges in creator-focused investing(19:46) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visitnorthwestregisteredagent.com/twist today!(22:24) Startups optimizing operations in challenging climates(24:50) Transition to fusion energy and Helion's technology(27:46) Helion's fusion technology and CEO David Kirtley(29:16) Commercial fusion power timeline(29:43) LinkedIn Ads. Get a $100 LinkedIn ad credit athttp://www.linkedin.com/thisweekinstartups(32:12) Fusion energy's market potential and agreements(33:39) Comparing fusion to other energy sources(36:10) Safety and environmental considerations for fusion(43:00) Helion's upcoming milestones and team expansion(44:00) Lon Harris on AI, copyright, and fair use(47:00) Exploring fair use and IP infringement in AI(53:00) Market impact and licensing for AI technologies(56:00) Financial implications for AI and copyright(58:00) Distinguishing personal vs. commercial use of copyrighted material

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LinkedIn:https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:

(9:41) Vanta. Get $1000 off your SOC 2 athttps://www.vanta.com/twist(19:46) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visitnorthwestregisteredagent.com/twist today!(29:43) LinkedIn Ads. Get a $100 LinkedIn ad credit athttp://www.linkedin.com/thisweekinstartups

Great TWIST interviews:Will Guidara,Eoghan McCabe,Steve Huffman,Brian Chesky,Bob Moesta,Aaron Levie,Sophia Amoruso,Reid Hoffman,Frank Slootman,Billy McFarland

Check out Jason’s suite of newsletters:https://substack.com/@calacanis

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Subscribe to the Founder University Podcast:https://www.youtube.com/@founderuniversity1916

Today on This Week in Startups: Lon Harris is back, and we’re diving into all things Super Bowl—especially the tech takeover in this year’s commercials. We break down the biggest ad moments, from Squarespace to Uber Eats, Instacart, and even Harrison Ford’s Jeep spot. Plus, we dig into Google Trends after the ChatGPT ad, the unexpected appeal ofThe Banshees of Inisherin, and Matthew McConaughey’s latest move with Salesforce. That’s not all—France is making bold AI moves, OpenAI is getting into chip development, and we’ve got aFounder Fridays competition coming up!

*

Timestamps:

(0:00) Jason, Alex and Lon “kick off” the show!(5:09) Breakout Super Bowl commercials(9:23) Rocket's Super Bowl ad and its impact

(10:21)Lemon.io. Get 15% off your first 4 weeks of developer time athttps://Lemon.io/twist(13:00) High-risk hobbies of the rich and famous(15:23) We all loved the new Squarespace ad and its effectiveness(19:07) The appeal of "The Banshees of Inisherin" and ChatGPT Super Bowl ad(20:17) OpenPhone. Get 20% off your first six months athttps://www.openphone.com/twist

(21:34) Google Trends analysis of ChatGPT ad impact(22:19) A look at Kendrick Lamar’s Super Bowll half-time show and his popularity(24:15) Rating the ChatGPT Super Bowl ad(31:01) Coda. Empower your startup with Coda’s Team plan for free—get 6 months athttps://www.Coda.io/twist(32:42) Uber Eats and Instacart Super Bowl ads & Harrison Ford's Jeep commercial(39:49) Matthew McConaughey's role with Salesforce and A-list actors in 2025(44:14) France's AI investment and strategy(47:10) AI in customer service and SaaS pricing(52:34) IT unemployment and AI's impact on tech support(56:45) Upcoming earnings reports from key tech companies(1:02:12) OpenAI's custom chip development with TSMC(1:02:35) Founder Fridays: A new initiative for founders and competition format*

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Thank you to our partners:

(10:21)Lemon.io. Get 15% off your first 4 weeks of developer time athttps://Lemon.io/twist(20:17) OpenPhone. Get 20% off your first six months athttps://www.openphone.com/twist(30:31)Coda. Empower your startup with Coda’s Team plan for free—get 6 months athttps://www.Coda.io/twist*

Great TWIST interviews:Will Guidara,Eoghan McCabe,Steve Huffman,Brian Chesky,Bob Moesta,Aaron Levie,Sophia Amoruso,Reid Hoffman,Frank Slootman,Billy McFarland

*

Check out Jason’s suite of newsletters:https://substack.com/@calacanis

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This Week in Startups is brought to you by…

Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain athttps://www.Squarespace.com/TWIST

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AdQuick. Visithttps://adquick.com/twist and mention TWIST to get $1000 off your first campaign.

Today’s show: Jason and Alex discuss the carried interest tax loophole being in Trump’s crosshairs, a great interview with Orbit Fab and their plans for the industrialization of space, Deel’s $300M secondary and much more!

Timestamps:

(0:00) Episode Teaser(1:30) Introduction and welcome(2:40) AI startups reaching revenue milestones(9:00) Impact of carried interest tax changes

(10:01) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain athttps://www.Squarespace.com/TWIST

(11:25) Would ending the carried interest tax loophole hurt startup investing?

(19:17) Atlassian. Head tohttps://www.atlassian.com/software/startups to see if you qualify for 50 free seats for 12 months.(21:18) Introduction of OrbitFab's CEO, Daniel Faber(22:24) OrbitFab's market position, fuel standards, and customer adoption(27:14) Financial and logistical aspects of satellite refueling

(29:27) AdQuick. Visithttps://adquick.com/twist and mention TWIST to get $1000 off your first campaign.(31:03) Technical challenges in space operations and future applications(34:16) Raising capital and company growth in space startups(38:58) Community updates and secondary transactions in the market(49:32) CapBase acquisition by Deal(50:37) UAE-France data center collaboration and energy strategy(54:34) European AI and nuclear advancements(57:14) US tech employment trends and Meta's layoffs(1:00:51) Opportunities for founders and startup support resources

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Thank you to our partners:

(10:01) Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain athttps://www.Squarespace.com/TWIST(19:17) Atlassian. Head tohttps://www.atlassian.com/software/startups to see if you qualify for 50 free seats for 12 months.(29:27) AdQuick. Visithttps://adquick.com/twist and mention TWIST to get $1000 off your first campaign.

Great TWIST interviews:Will Guidara,Eoghan McCabe,Steve Huffman,Brian Chesky,Bob Moesta,Aaron Levie,Sophia Amoruso,Reid Hoffman,Frank Slootman,Billy McFarland

Check out Jason’s suite of newsletters:https://substack.com/@calacanis

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This Week in Startups is brought to you by…

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Today’s show: Jason and Alex cover Palantir’s surge (is it all hype?), Temo and Shein and the de minimise loop hole, Uber’s earnings and the future of self-driving technology and much more!

Timestamps:

(0:00) Episode Teaser

(11:27) Alex Karp talks up Palantir to investors

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

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Follow Alex:

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Follow Jason:

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LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:

(9:49) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

Follow TWiST:

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Substack: https://twistartups.substack.com

Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

OpenAI dropped Deep Research—hilariously, the exact same name as Google’s existing tool. Jason and Alex dive into the AI arms race, break down Lovable.dev’s insane growth to $10M ARR in weeks, and test whether AI can really replace software engineers. Plus, they analyze Trump’s latest tariff chaos and what it means for startups, global trade, and the economy.

*

Timestamps:

(0:00) Jason and Alex kick off the show.

(1:09) Jason’s talk and case study at Stanford

(21:39) Custom software development's future with AI

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

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Check out:

Standford Case Study on Jason: https://www.gsb.stanford.edu/faculty-research/case-studies/jason-calacanis-case-study-creating-resources

OpenAI’s Deep Research: https://openai.com/index/introducing-deep-research/

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Follow Anton

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Website: www.lovable.dev

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X: https://x.com/alex

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X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

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Thank you to our partners:

(0:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

*

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

*

Follow TWiST:

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Substack: https://twistartups.substack.com

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Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Today’s show: The AI revolution is about to hit your household—Jason and Alex break down how general-purpose robots, AI-powered chicken coops, and voice clones are redefining daily life and work. They dig into OpenAI’s sky-high valuation, the surprising rise of DeepSeek’s R1 model, and why the AI cost curve is dropping at an insane pace. Plus, the latest on AI hardware, antitrust battles, and why the “No Buy 2025” trend could change how we think about consumer tech.

*

Timestamps:

(0:00) Jason and Alex kick off the show.

(21:22) Market trends towards sustainability and AI in smart chicken coops

*

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Follow Alex:

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Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

*

Thank you to our partners:

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

*

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

*

Follow TWiST:

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Substack: https://twistartups.substack.com

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This Week in Startups is brought to you by…

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Today’s show: Jason and Alex cover Jason’s unique sauna experience, leading them to discuss the value of niche communities and supporting small startups, spotlighting Boom Supersonic's achievements and Starlink's aviation collaborations. Financial updates include the Federal Reserve's actions and Trump's public opinion. They analyze the impact of CapEx on tech giants and Meta's AR/VR success. The DeepSeek controversy, OpenAI's intellectual property issues, and AI race risks and opportunities are explored. Jason and Alex conclude with insights on building startups and modern tools for entrepreneurs.

Timestamps:

(0:00) Episode Teaser

(13:48) Boom Supersonic's achievements and flight details

(20:47) Northwest Registered Agent. For just $39 plus state fees, Northwest will handle your complete business identity. Visit ⁠https://www.northwestregisteredagent.com/twist⁠ today.

(30:14) Scalable Path. Get 20% off your first month at https://www.scalablepath.com/twist

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Check out:

Boom Supersonic: https://boomsupersonic.com/

GoPolar App: https://www.gopolar.app/

Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:

(10:11) Vanta. Get $1000 off your SOC 2 at https://www.vanta.com/twist

(30:14) Scalable Path. Get 20% off your first month at https://www.scalablepath.com/twist

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

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