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Tinnitus Treatments Result From Clinical Trials
This week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and there are some symptomatic treatments. Listen in to find out what tinnitus is, risks and complications, and some ways you may be able to find relief.
References:
Bhatt, J. M., Lin, H. W., & Bhattacharyya, N. (2016). Prevalence, severity, exposures, and treatment patterns of tinnitus in the United States. JAMA Otolaryngology–Head & Neck Surgery, 142(10), 959-965. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2533660
Shargorodsky, J., Curhan, G. C., & Farwell, W. R. (2010). Prevalence and characteristics of tinnitus among US adults. The American journal of medicine, 123(8), 711-718. https://pubmed.ncbi.nlm.nih.gov/30073285/
Makar, S. K. (2021). Etiology and pathophysiology of tinnitus: a systematic review. The International Tinnitus Journal, 25(1), 76-86. https://www.tinnitusjournal.com/articles/etiology-and-pathophysiology-of-tinnitus--a-systematic-review-16383.html
Dalrymple, S. N., Lewis, S. H., & Philman, S. (2021). Tinnitus: diagnosis and management. American family physician, 103(11), 663-671. https://www.aafp.org/pubs/afp/issues/2021/0601/p663.html
Shore, S. E., & Wu, C. (2019). Mechanisms of noise-induced tinnitus: insights from cellular studies. Neuron, 103(1), 8-20. https://www.cell.com/neuron/fulltext/S0896-6273(19)30433-7
Staecker, H., Morelock, M., Kramer, T., Chrbolka, P., Ahn, J. H., & Meyer, T. (2017). Safety of repeated-dose intratympanic injections with AM-101 in acute inner ear tinnitus. Otolaryngology–Head and Neck Surgery, 157(3), 478-487. https://pubmed.ncbi.nlm.nih.gov/28608739/
National Library of Medicine. (n.d.). ClinicalTrials.gov. U.S.Department of Health and Human Services. [Website. Accessed 24 March, 2024]. https://clinicaltrials.gov/search?cond=Tinnitus&aggFilters=results:with,status:com&locStr=United%20States&country=United%20States
Beukes, E. W., Andersson, G., & Manchaiah, V. (2021). Patient uptake, experiences, and process evaluation of a randomized controlled trial of internet-based cognitive behavioral therapy for tinnitus in the United States. Frontiers in medicine, 8, 771646. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.771646/full
Conlon, B., Hamilton, C., Meade, E., Leong, S. L., O Connor, C., Langguth, B., ... & Lim, H. H. (2022). Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial. Scientific reports, 12(1), 1-18. https://www.nature.com/articles/s41598-022-13875-x
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By MedEvidence ArticlesThis week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and there are some symptomatic treatments. Listen in to find out what tinnitus is, risks and complications, and some ways you may be able to find relief.
References:
Bhatt, J. M., Lin, H. W., & Bhattacharyya, N. (2016). Prevalence, severity, exposures, and treatment patterns of tinnitus in the United States. JAMA Otolaryngology–Head & Neck Surgery, 142(10), 959-965. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2533660
Shargorodsky, J., Curhan, G. C., & Farwell, W. R. (2010). Prevalence and characteristics of tinnitus among US adults. The American journal of medicine, 123(8), 711-718. https://pubmed.ncbi.nlm.nih.gov/30073285/
Makar, S. K. (2021). Etiology and pathophysiology of tinnitus: a systematic review. The International Tinnitus Journal, 25(1), 76-86. https://www.tinnitusjournal.com/articles/etiology-and-pathophysiology-of-tinnitus--a-systematic-review-16383.html
Dalrymple, S. N., Lewis, S. H., & Philman, S. (2021). Tinnitus: diagnosis and management. American family physician, 103(11), 663-671. https://www.aafp.org/pubs/afp/issues/2021/0601/p663.html
Shore, S. E., & Wu, C. (2019). Mechanisms of noise-induced tinnitus: insights from cellular studies. Neuron, 103(1), 8-20. https://www.cell.com/neuron/fulltext/S0896-6273(19)30433-7
Staecker, H., Morelock, M., Kramer, T., Chrbolka, P., Ahn, J. H., & Meyer, T. (2017). Safety of repeated-dose intratympanic injections with AM-101 in acute inner ear tinnitus. Otolaryngology–Head and Neck Surgery, 157(3), 478-487. https://pubmed.ncbi.nlm.nih.gov/28608739/
National Library of Medicine. (n.d.). ClinicalTrials.gov. U.S.Department of Health and Human Services. [Website. Accessed 24 March, 2024]. https://clinicaltrials.gov/search?cond=Tinnitus&aggFilters=results:with,status:com&locStr=United%20States&country=United%20States
Beukes, E. W., Andersson, G., & Manchaiah, V. (2021). Patient uptake, experiences, and process evaluation of a randomized controlled trial of internet-based cognitive behavioral therapy for tinnitus in the United States. Frontiers in medicine, 8, 771646. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.771646/full
Conlon, B., Hamilton, C., Meade, E., Leong, S. L., O Connor, C., Langguth, B., ... & Lim, H. H. (2022). Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial. Scientific reports, 12(1), 1-18. https://www.nature.com/articles/s41598-022-13875-x