Matthew Stafford's historic touchdown streak meets a vulnerable San Francisco 49ers defense. Can the Rams quarterback continue his dominance, or will Week 10's challenging matchups shake up fantasy rosters?

Marcus Mosher and Michael Fabiano break down critical starts and sits across all positions for Week 10, analyzing why Rico Dowdle's 27-touch performance makes him a must-start against the Saints, while Alvin Kamara's decline continues despite his big name.

The discussion covers Drake Maye's emergence as a reliable fantasy option, the impact of JJ McCarthy's limited passing on Justin Jefferson and Jordan Addison, and why Roma Odunze could bounce back after his father's social media campaign. Key streaming options include Cade Otten against a Patriots defense that's surrendered double-digit points to six tight ends, plus Zach Charbonnet and Jameson Williams as bye-week replacements.

Discover which players to trust and which matchups to avoid as four teams sit out Week 10.

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