In this episode, we provide a comprehensive overview of traumatic brain injury (TBI), from foundational definitions and epidemiology to critical emergency nursing interventions. We’ll distinguish between open and closed head injuries and examine the life-threatening consequences of increased intracranial pressure (ICP), including changes in level of consciousness, pupillary response, and vital signs. Using current data, we’ll discuss common causes of TBI—highlighting falls as the leading mechanism—and identify high-risk populations such as young males and older adults. Medical management strategies are explored in detail, including osmotic diuretics, surgical evacuation of hematomas, and vigilant monitoring for cerebrospinal fluid leaks. Nursing priorities extend beyond acute care, with a focus on discharge education, recognition of delayed neurologic deterioration, and prevention of complications. Finally, we address the potential for long-term disability and review the clinical criteria for brain death, reinforcing the nurse’s essential role in assessment, advocacy, and patient and family support throughout the continuum of care.