TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode  Converting  glia to neurons (Cell) Reversing Parkinson's disease (Nature) Letters read on TWiN 8 Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 8: Replacing lost neurons

Natural Sciences

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Life Sciences

TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19.  Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free):  Apple Podcasts, Google Podcasts, RSS Links for this episode  MicrobeTV Discord Server SARS-CoV-2 perturbs synaptic homeostasis (Nature Micro) Timestamps by Jolene. Thanks!  Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 50: Neurological sequelae after COVID-19

TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition.  Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Subscribe (free):  Apple Podcasts, Google Podcasts, RSS Links for this episode  MicrobeTV Discord Server Mice are self-aware (Neuron) Mirror self-recognition in mice (Neuron) Timestamps by Jolene. Thanks!  Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?

TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free):  Apple Podcasts, Google Podcasts, RSS Links for this episode  MicrobeTV Discord Server Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene. Thanks!  Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 48: Traumatic brain injury and retroviruses

TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free):  Apple Podcasts, Google Podcasts, RSS Links for this episode  MicrobeTV Discord Server Walking naturally after spinal cord injury (Nature) The paralyzed rat that walked (YouTube) Mike the headless chicken (Wikipedia) Timestamps by Jolene. Thanks!  Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 47: Walking after spinal cord injury

TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.  Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode  MicrobeTV Discord Server Glioma synapses recruit mechanisms of adaptive plasticity (Nature) Timestamps by Jolene. Thanks!  Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN 8: Replacing lost neurons

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