Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis. Host: Vincent Racaniello Guests: Raul Andino and Kostya Chumakov Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Engineering OPV (Cell Host Microbe)  Poliopolis (Lancet) nOPV2 (Polioeradication.org) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 1041: Novel oral polio vaccine? with Raul Andino and Kostya Chumakov

TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.

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TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Grants Register for ASV Annual Meeting  H5N1 influenza virus in raw cow milk infects mice (NIAID News) Dynamics of measles virus immunity from birth (Nat Comm) Mechanism of cis-preferential HBV reverse transcription (Cell) Timestamps by Jolene. Thanks!  Weekly Picks Dickson – Oldest virus in Neanderthal bones Brianne – Jeopardy! winner reveals entwined memory systems make a trivia champion Kathy – Bright future of intelligent fabrics primary article and Self-dyeing textiles (primary article) Rich – Farewell to HD Atlas; Boston Dynamics Retires HD Atlas Robot Alan – Why vaccinating cattle against H5N1 is hard Vincent – Singapore Airlines turbulence: why climate change is making flights rougher Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 1117: Pol dances with the RNA that brought it

In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088. Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!  Links for this episode  Clade 2.3.4.4b of highly pathogenic H5N1 in NYC (J Vi) Avian and human influenza A receptors in bovine mammary glands (bioRxiv) Where livestock infected with HPAI live (USDA) Another dairy worker contracted bird flu (NY Times)  Reluctance to test for H5N1 (STAT News) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Estimates of hospitalization and deaths prevaccination era (Emerg Inf Dis)  Slightly less than half of COVID-19 patients died prevaccination (CIDRAP) Spring vaccine advice (CIDRAP)  Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC)  Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)  EUA for pemgarda (FDA)  CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH)  Infectious Disease Society guidelines for treatment and management (IDSociety) Drug interaction checker (University of Liverpool)  Global phase 3 study of ensitrelvir (Shionogi) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Remember when monoclonal antibody therapies worked (JID) Steroids, dexamethasone at the right time (OFID)  Anticoagulation guidelines (hematology.org)  Global clinical study of long COVID-19 (International Journal of Infecitous Diseases)  Cardiopulmonary exercises testing of children with long COVID-19 (Pediatric Infectious Disease Journal) Phase 2 trial of RSVL-132 for severe fatigue related to PASC (CID)  Muscle training may improve diaphragm muscle weakness 2 years after COVID-19 (American Journal of Respiratory Critical Care Health) Long COVID evidence based review TWiV shout out (TWiV 1088) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1116 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1116: Clinical update with Dr. Daniel Griffin

TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Hosts: Dickson Despommier, Alan Dove and Brianne Barker Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server MicrobeTV store at Cafepress Michelson Prizes: Next Generation Grants Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (Lancet Inf Dis) First self-amplifying mRNA vaccine approved in Japan (Science) Rise of the RNA machines (Trends Biochem) Innate and T cell populations correlates of protection against influenza (Nat Immunol) Timestamps by Jolene. Thanks!  Weekly Picks Dickson - Nitrogen-fixing organelle in a marine algaBrianne – Mapping a lost branch of the Nile Alan – Interactive version of the updated USDA gardening zone map on NPR. Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 1115: Calling the CoPs on flu

In his weekly clinical update, Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088. Dr. Griffin also provides a list of apps for monitoring one’s health including brain health. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!  Links for this episode  Who demands milk infected with H5N1? (Futurism)  Uncowed by milk possessing H5N1  (LA Times) Cow flu flying around for 4 months (CNN) The unpasteurized raw milk institute (Raw Milk Institute) Infection and reproduction of H5N1 in the human gut (JID)  Wastewater samples identified H5N1 in 9 cities (medrxiv) Richard Webby, is H5N1 a concern? (TWiV 1113) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Spring vaccineadvice (CIDRAP)  Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC)  Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)  Withdrawal of Astra-Zeneca SARS-CoV-2 vaccine in Europe (European Medicines Agency)  Astra-Zeneca withdraws SARS-CoV-2 vaccine from market (AP news) Global vaccine data/adverse event network (Vaccine)  EUA for pemgarda (FDA)  CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH)  Infectious Disease Society guidelines for treatment and management (IDSociety) Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID)  Anticoagulation guidelines (hematology.org)  Colchicine for managing COVID-19 (BMC Pulmonary Medicine)  Colchicine guidelines (ID Society) Long COVID evidence based review TWiV shout out (TWiV 1088)  NIH long COVID sleep disturbance, exercise intolerance and post exertional malaise clinical trials (NIH News) COVID-19 Yorkshire rehabilitation scale (BML Open Respiratory Research) Visible heart monitor (Makevisible) Bearable app (Bearable) Tracking your chronic illness using Flaredown (Flaredown) Improving your brain health (BrainHQ)Vanderbilt’s long COVID resources: podcasts and books (Vanderbilt University) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1114 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!  Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1114: Clinical update with Dr. Daniel Griffin

Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Webby Subscribe (free):  Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode  MicrobeTV Discord Server MicrobeTV store at Cafepress Webby research laboratory H5N1 virus in dairy cattle and cats (Emerg Inf Dis) Emergence of H5N1 virus in dairy cattle (bioRxiv) Spillover potential of H9N2 bat virus (Nat Commun and TWiV 1111) Letters read on TWiV 1113 Timestamps by Jolene. Thanks!  Weekly Picks Brianne – The Little Researcher (from Bioss) Alan – Global Polio Eradication Initiative’s OPV switch was “unqualified failure.” Vincent – Errant Science Listener Picks Moragh – Paper Cuts Podcast Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV 1041: Novel oral polio vaccine? with Raul Andino and Kostya Chumakov

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