It’s well known that screening for mutations in certain breast cancer genes can help determine a woman’s risk of breast and ovarian cancer. Now, a new study led by John Witte of the University of California, San Francisco suggests that a similar test could be done for prostate cancer. Witte says that unlike other diseases, the test would be based on over 100 smaller, known genetic risk factors.
"Here we're in a situation, for most people, they don't carry that one really big mutation. Instead, they have this huge range of different mutations that each one by itself has a very small increase in risk. So what we showed in this study was that, if you actually combine a hundred of these different genetic factors together, then your risk is much higher."
Witte says that the test could provide clinical value as more genetic variants are discovered.
"You may be able to actually screen someone and look at their germ line DNA and determine who's at the highest risk of prostate cancer in a magnitude that's similar to those breast cancer genes, which are commonly tested for now in women."