Join us on our first episode of the Scintica Morning Coffee Chat.

This series is dedicated to discussing the use cases and benefits of different imaging modality and exploring how they can be combined symbiotically in your workflow.

On this exciting episode, two Scintica Product Managers, Dr. Sadi Loai and Dr. Jade Marrow, will venture into the world of multimodal imaging. Sadi and Jade will address multiple questions about how the ultrasound and DEXA systems offer their distinct advantages. but also where they fall short. Ultimately, they conclude how combining these modalities can be beneficial for in vivo imaging in preclinical and clinical research.

Sadi and Jade respond to multiple questions at how their modalities offer their distinct advantages but also where they fall short. Ultimately, they conclude how combining these modalities are beneficial for in vivo imaging in preclinical research.

Key points discussed:

• How DXA provides validated quantitative measures of bone density, fat, and lean mass
• How ultrasound adds functional and dynamic insights into tissue stiffness, perfusion, and elasticity
• When and how why multimodal imaging offers superior reproducibility and maximizes data integrity ethical advantages
• Strategies to combine both technologies systems for metabolic, musculoskeletal, and translational disease models

In this episode, we explore whether a reductionist approach in cancer research is a limitation—or an opportunity. Bioprinting is emerging as a transformative technology that enables the creation of complex 3D tumor models, allowing researchers to study cancer in ways that better reflect human physiology. We discuss how bioprinting addresses the shortcomings of traditional 2D cultures and animal models, and how it empowers scientists to isolate and examine specific variables within the tumor microenvironment. From personalized tumor models to high-throughput drug screening and ethical advantages, bioprinting is reshaping the path toward more predictive and effective therapies. Join us as we ask: is this simplification actually the key to unlocking complexity?

On this episode, we are featuring Mr. Terry Jordan. Terry is going to tell us a wonderful story filled with a roller coaster of emotions, ups and downs about his life, his journey through battling cancer - being an Iran-Iraq war veteran, and talking about his journey into making music.

Listen to Terry's music here: https://open.spotify.com/artist/1BBW38x8aYMr9XnPRXzFaG?si=_ip54dSTTfW8_Idpn6u51A

Listen to Check your Poo Today: https://open.spotify.com/track/2tFgDKdJRtCIk1rpuBfolP?si=083ffb3985854c9c

Make a donation to Terry's Runners for Research charity: AACR.org/5K/TerryJordan

Welcome to another episode of Under the Microscope with Scintica. On this episode, Tyler talked with Dr. Dhanvantari about her journey in science, learned about her personal life and her current/past projects in the fields of diabetic and cardiac research. She is also involved in the diversity and inclusion group of the world molecular imaging society

Dr. Savita Dhanvantari received a B.Sc. in Zoology from the University of Guelph, an M.Sc. in Zoology from Western University, and a Ph.D. in Physiology from the University of Toronto. She carried out her post-doctoral studies at the National Institutes of Health in Bethesda, MD under the supervision of Dr. Y. Peng Loh.

In 2002, she joined the Lawson Health Research Institute where she is a scientist in both the Metabolism and Diabetes Program and the Imaging Program. She is also an Assistant Professor in the Department of Medical Biophysics at the University of Western Ontario, and cross-appointed to the Department of Pathology and Laboratory Medicine.

Dr. Dhanvantari Research Areas: Development of GLP-1 receptor probes for imaging changes in beta cell mass, Functional molecular imaging of the pancreatic islet, Non-invasive Molecular Imaging of Cancer Growth and Metastasis Using MRI and a Novel Reporter Gene, Molecular Imaging of the pancreatic islet using dual-isotope SPECT/CT, Role of the prohormone convertases in pancreatic alpha cell function, Molecular and cellular mechanisms of the innate immune response in the development of type 1 diabetes

Welcome to another episode of Under the Microscope with Scintica. On this episode, we have two special guests, Dr. Ben Rush & Dr. Jevin Lortie.

Dr.Jevin Lortie is currently conducting post-doctoral research at the University of Wisconsin - Madison in the Nutritional Sciences Department. He grew up in the Chicago, Illinois area. He was first introduced to science by experimenting with cooking and baking. His current research involves muscle imaging, gut microbiome, and heart failure.

Dr. Ben Rush attended Indiana University Bloomington for his undergrad and masters in public health, where he served as a graduate student researcher. He served two years with the American corps as a personal chef. He later returned to graduate school to obtain his Ph.D. in nutritional sciences where he studied how various body composition and bio-imaging methods can capture muscle quality with the goal to use those methods in lung cancer and aging intervention.

Ben is also the founder of the Deeper than Data Podcast where he explores the personal journeys, failures, and successes of scientists through storytelling and humor. Listen to the Deeper than Data Podcast: https://deeperthandata.media/

Listen to other Under the Microscope stories: https://www.scintica.com/under-the-microscope/

Learn more about Scintica: https://www.scintica.com/

Welcome to the final part of the Under the Microscope series with Dr. James Trosko!

Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu,[13] could stably inhibit GJIC, while tumor suppressor genes [14], as well as multiple cancer chemo-preventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.) [15-20], and even some chemotherapeutic agents ( Lovastatin ,SAHA) [21, 22], could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC.

Learn more about Dr. Trosko: https://integrativebiology.natsci.msu...

Check out our other Under the Microscope stories: https://www.scintica.com/under-the-mi...

Visit us at www.scintica.com for more information

Welcome to part 3 of the Under the Microscope series with Dr. James Trosko!

Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, pthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu,[13] could stably inhibit GJIC, while tumor suppressor genes [14], as well as multiple cancer chemo-preventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.) [15-20], and even some chemotherapeutic agents ( Lovastatin ,SAHA) [21, 22], could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC.

Learn more about Dr. Trosko: https://integrativebiology.natsci.msu...

Check out our other Under the Microscope stories: https://www.scintica.com/under-the-mi...

Visit us at www.scintica.com for more information

Welcome to part 2 of the Under the Microscope with Dr. James Trosko.

Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process.

He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations.

Also, his lab discovered that oncogenes, such as src, ras, raf, neu, could stably inhibit GJIC, while tumor suppressor genes, as well as multiple cancer chemopreventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.), and even some chemotherapeutic agents (Lovastatin ,SAHA), could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC.

In this first episode, Dr. Trosko is going to walk us through his amazing journey in science.

Learn more about Dr. Trosko:

https://integrativebiology.natsci.msu.edu/alumni-and-friends/alumni-profiles/trosko-james-e/

Visit us at www.scintica.com for more information

Welcome to part 1 of the Under the Microscope with Dr. James Trosko.

Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process.

He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations.

Also, his lab discovered that oncogenes, such as src, ras, raf, neu, could stably inhibit GJIC, while tumor suppressor genes, as well as multiple cancer chemopreventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.), and even some chemotherapeutic agents (Lovastatin ,SAHA), could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC.

In this first episode, Dr. Trosko is going to walk us through his amazing journey in science.

Learn more about Dr. Trosko:

https://integrativebiology.natsci.msu.edu/alumni-and-friends/alumni-profiles/trosko-james-e/

Visit us at www.scintica.com for more information

Dr. Anand Narayanan has an interdisciplinary background in engineering, biology, and physiology, with specialized training in cardiovascular sciences, in lymphatics while at Texas A&M University and in heart and blood vascular adaptations now at Florida State University, having also studied cardiovascular-coupled organ system adaptations including cerebral, musculoskeletal, and gastrointestinal physiology. He has more than 10 years of physiology and immunology experience, in various research areas including auto-immune conditions, old age, exercise training, etc. His current research focuses on the interaction between the immune system and how it affects cardiovascular physiology.