On this week's episode, we review celiac disease. We talk about what it is, and what goes wrong inside the body. We discuss the underlying genetic factors and why genetics alone aren't enough to guarantee celiac disease. We wrap up on a hopeful note, exploring new avenues to be explored in clinical research trials.

References:

Lebwohl, B., & Rubio-Tapia, A. (2021). Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), 63-75. https://www.gastrojournal.org/article/S0016-5085%2820%2935165-9/fulltext

Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E., Makharia, G. K., Mearin, M. L., ... & Kaukinen, K. (2019). Coeliac disease. Nature reviews Disease primers, 5(1), 3. https://www.nature.com/articles/s41572-018-0054-z

Sollid, L. M. (2000). Molecular basis of celiac disease. Annual review of immunology, 18(1), 53-81. https://www.annualreviews.org/content/journals/10.1146/annurev.immunol.18.1.53

King, J. A., Jeong, J., Underwood, F. E., Quan, J., Panaccione, N., Windsor, J. W., ... & Kaplan, G. G. (2020). Incidence of celiac disease is increasing over time: a systematic review and meta-analysis. The American journal Gastroenterology, 115(4), 507-525. https://journals.lww.com/ajg/abstract/2020/04000/incidence_of_celiac_disease_is_increasing_over.9.aspx

Kelly, C. P., Murray, J. A., Leffler, D. A., Getts, D. R., Bledsoe, A. C., Smithson, G., ... & Turner, M. (2021). TAK-101 nanoparticles induce gluten-specific tolerance in celiac disease: a randomized, double-blind, placebo-controlled study. Gastroenterology, 161(1), 66-80. https://www.gastrojournal.org/article/S0016-5085(21)00521-7/fulltext