University of California Video Podcasts (Video)

Dr. Robert Baron outlines major updates in type 2 diabetes care, emphasizing that blood sugar control alone does not significantly reduce cardiovascular risk, though it helps prevent microvascular complications. New guidelines now prioritize medications with proven cardiovascular and kidney benefits—GLP-1 receptor agonists and SGLT2 inhibitors—over traditional first-line therapy like metformin. Baron explains how these newer drugs not only lower blood sugar but also reduce the risk of heart attack, stroke, kidney disease, and heart failure, with added benefits such as weight loss. He also covers changes in screening, diagnosis, blood pressure goals, and individualized treatment strategies based on age, comorbidities, and patient preferences. [Health and Medicine] [Show ID: 40756]

Nature's fury can be devastating on Earth. Typhoon Nepartak over the South China Sea in 2016 caused severe damage and deaths in China, Taiwan and the Phillipines. Yet seen from the International Space Station, the typhoon looks surprisingly serene. These artfully photographed images from astronauts aboard ISS 48 are set to the music of Catherine Brisset and her cristal Baschet, a unique glass keyboard with fanciful metal shapes to help the mysterious sounds resonate. Brisset plays a variation on Bach’s Sonata #2, the Grave movement, with such subtle and emotive touch. Series: "Arts Channel " [Arts and Music] [Show ID: 40977]

Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]

Legal scholar Annabel Brett explores the idea of “moral possibility”—the boundary between what laws demand and what people can realistically or ethically be expected to do. Drawing from early modern thinkers like Aquinas, Suarez, and Hobbes, Brett shows how moral impossibility has long shaped debates about legal obligation, resistance, and political agency. Commentators Melissa Lane and David Dyzenhaus join the discussion, examining how this concept applies to everything from climate action and military conscription to unjust regimes and democratic norms. Together, they highlight how institutions, customs, and time shape the space between legal duty and human capacity—and why recognizing this gap is vital to both justice and legitimacy. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40431]

Marni Jacobs, Ph.D., M.P.H., presents the MOM Health Study, part of the NIH's Multi-Omics for Health and Disease (MOHD) Consortium, which investigates hypertensive disorders of pregnancy—such as preeclampsia—and their impact on postpartum health. The study aims to uncover the biological mechanisms linking these conditions to long-term maternal outcomes like stroke and heart disease. Unlike other disease sites, participants are enrolled before outcomes are known, allowing researchers to track 750 pregnancies through delivery and one year postpartum. Data collection includes surveys, biospecimens, placental tissue, and continuous blood pressure monitoring. By integrating clinical, environmental, and molecular data, the study supports early detection strategies and collaborative research to improve maternal health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40671]

Louise Laurent, M.D., Ph.D., presents new insights into placental biology using cutting-edge molecular and imaging technologies. As part of the NIH-funded Human Biomolecular Atlas Program, her research focuses on mapping the structure and function of the placenta across gestation. By combining bulk RNA sequencing, single-cell analysis, spatial transcriptomics, and imaging mass cytometry, Laurent and collaborators identify key differences in cell types and gene expression associated with pregnancy stages and labor. Her team highlights how specific cells like syncytiotrophoblasts and extravillous trophoblasts evolve over time and interact with maternal tissue. This integrated approach offers an unprecedented view of placental development and lays the groundwork for understanding reproductive health and disease. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40670]

Dr. Ivan de Kouchkovsky explains how radioligand therapy delivers targeted radiation to prostate cancer cells using a radioactive isotope attached to a molecule that binds to PSMA, a protein commonly expressed in these tumors. He reviews key clinical trials showing how the therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer, both after and before chemotherapy. The FDA now approves this approach for patients who have progressed on hormone therapy, even if they haven’t yet received chemotherapy. De Kouchkovsky also highlights efforts to enhance effectiveness by combining therapies, increasing radiation dose, and targeting resistant or PSMA-negative cells. Diagnostic imaging plays a critical role in selecting patients most likely to benefit from treatment. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40810]

UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]

Political theorist Annabel Brett of Cambridge University explores how the concept of “moral possibility” shapes law, politics, and public obligation. She explains that laws must be realistic for people to follow—what is morally possible varies by individual, culture, time, and circumstance. Drawing on early modern Catholic legal theory, Brett discusses how extreme demands (like enduring war or plague) may justify higher expectations, but only temporarily. She examines how colonial Spanish officials misused this framework to justify forced labor in Peru, wrongly claiming it aligned with indigenous customs. Brett contrasts this with more democratic approaches to law, like Domingo de Soto’s defense of beggars’ rights, which take individuals’ real conditions seriously. Ultimately, she shows how moral possibility is deeply tied to time, virtue, and justice. Commentary is provided by David Dyzenhaus of the University of Toronto. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40430]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]