University of California Video Podcasts (Video)

The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40702]

There's a powerful idea in the history of European legal and political thought: that laws must be possible for people to follow. Annabel Brett, professor of Political Thought and History at Cambridge University, describes how from ancient times through the Renaissance, thinkers believed that demanding the impossible—whether physically or psychologically—was a hallmark of tyranny. A classic example is Pharaoh in the Book of Exodus, who ordered the Israelites to make bricks without straw. Brett analyzes how legal thinkers balanced the need for law to be both realistic and aspirational, and how these ideas shaped the development of modern legal systems. Brett is joined by Princeton University's Melissa Lane for commentary. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40429]

Earth Serenade presents some July 4th fireworks with exuberant and playful dance between violinist Angie Shyr and alto saxphonist Chris Cheek as we fly over the deep browns and reds of Sahara followed by night views of the Mediterranean. The images are from ISS 67. Enjoy this wonderful collection of Earth and music. Series: "Arts Channel " [Arts and Music] [Show ID: 40880]

Humans have long been exposed to three main types of smoke: from early domestic fires, modern wildfires, and more recently, tobacco and fossil fuel pollution. All release tiny particles from partly burned plants, containing harmful chemicals like nitrogen oxides and carcinogens. These particles raise risks for lung cancer, dementia, and even childhood obesity. Studies show that air pollution can disrupt brain chemistry, increase Alzheimer’s-related proteins, and activate stress-related genes (NFkB, Nrf2). A new drug (GSM-15606) shows promise in reducing brain damage from pollution in mice. People with the ApoE4 gene may be more vulnerable, while the ApoE3 gene, possibly evolved 200,000 years ago, may offer some protection. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40700]

As part of the 2025 Developmental Disabilities Conference, Dr. Whitney Deal, an emergency physician at MedStar Union Memorial Hospital, talks about using the least restrictive approach when dealing with an agitated autistic patient. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40614]

In this excerpt, Dr. Natalie Marshall shares tips on starting exercise routines. Dr. Marshall emphasizes how doing something, exercise-wise, is significantly better than doing nothing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40687]

UCSF oncologist Dr. Jonathan Chou discusses how genetics and genomics are transforming the diagnosis and treatment of prostate cancer. He explains how inherited and acquired mutations—especially in DNA repair genes like BRCA2—can impact both cancer risk and treatment decisions. Dr. Chou outlines how UCSF researchers use tumor and blood-based biopsies to identify key mutations and genomic features that help tailor care for each patient. Examples include how genomic scores can predict response to radiation and how targeted therapies like PARP inhibitors benefit patients with specific mutations. The talk highlights the growing role of precision medicine in guiding individualized treatment plans based on the unique genetic profile of each patient’s cancer. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40798]

What paradoxes arise when victims of related persecution tell their stories next to, and after, each other? This question is at the heart of Ari Joskowicz’s highly acclaimed book “Rain of Ash,” which examines the unlikely entanglement of the histories of Jews and Romani people—the only two racialized groups the Nazis targeted for wholesale extermination. Joskowicz, professor of Jewish Studies at Vanderbilt University, explores the encounters between Jews and Romani people on the killing fields of Europe and seeks to understand how survivors and historians have discussed Romani and Jewish suffering during World War II in relational terms. Series: "Library Channel" [Humanities] [Show ID: 40533]

The human gut microbiome is tightly linked our health. Our analyses of diverse human populations from around the globe, ranging from hunter-gatherer to industrialized, show that the gut microbiome is profoundly influenced by lifestyle. With a large collaborative team, we conducted deep metagenomic sequencing of the gut microbiomes of Tsimane horticulturalists from Bolivia and compared them to those of Hadza hunter-gatherers from Tanzania. We are also investigating whether diet and microbial therapies can address deficiencies in the industrialized gut community. Molecular mechanisms of host-microbial interaction are pursued using an array of technologies and experimental approaches including gnotobiotic and conventional mouse models, quantitative imaging, and a metabolomics pipeline focused on investigating microbiota-dependent metabolites. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40698]

UCSF's Dr. Rahul Aggarwal explains the role of clinical trials in advancing prostate cancer treatment and how trial design is evolving to match today’s more personalized approaches. He highlights how UCSF has contributed to major prostate cancer therapies and emphasizes the importance of genetic and genomic testing in identifying suitable trials for each patient. Dr. Aggarwal explains the different trial phases, clarifies common myths—such as concerns about placebos—and stresses that trials are considered at every stage of disease. He also discusses efforts to improve access, affordability, and diversity in trial participation, including regional partnerships and digital matching tools. The talk encourages patients to be informed and proactive when considering clinical trials as part of their treatment plan. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40800]