Schizophrenia is one of the most challenging psychiatric disorders, marked by profound disruptions in thought, perception, and behavior. In this episode, we’ll break down the clinical features of schizophrenia, from positive symptoms like hallucinations and delusions to negative symptoms such as flat affect and anhedonia. We’ll explore its epidemiology, risk factors, and diverse clinical courses, alongside underlying neurobiological findings like neurotransmitter imbalances and structural brain changes. Nursing care is at the forefront, with a focus on comprehensive assessment, therapeutic interventions, patient education, and safety—particularly suicide risk prevention and management of antipsychotic side effects. We’ll also differentiate schizophrenia from related psychotic disorders, including schizophreniform and brief psychotic disorder, and revisit Bleuler’s “4 A’s” as a cornerstone in understanding this complex condition. Through a holistic lens, we’ll emphasize not only symptom management but also advocacy, recovery, and support for patients and families.