Michael Rae is the author with Aubrey De Grey of “Ending Aging”, and “is the author of five scientific articles and commentaries in peer-reviewed scientific journals. Much of his work has been devoted to elucidating the SENS platform for anti-aging biomedicine for a popular audience. His undergraduate minor was in biology. He is a long-time member and one-time Board Member of the Calorie Restriction Society, a main contributor to the Society’s “How-to Guide”, and was core scientific investigator with the CR Society Cohort Study.”

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PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

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Website: https://www.learningwithlowell.com/

Michael Rae links

https://www.sens.org/author/michael-rae/

https://www.sens.org/iron-fist-unleashed-new-senolytic-strategy/

https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroughs-Lifetime/dp/0312367074

https://www.linkedin.com/in/michael-rae-92818223a/

Timestamps

00:00 Intro Michael Rae

01:10 Science behind nutrition / fact from fiction

11:40 Counter arguments for calorie restriction on aging, longevity, and health

18:13 Experiments supporting Calories restriction benefits

22:55 Cost of Calorie restriction diet 

23:46 Nir Barzali Vs Bryan Johnson Supplement debate and impact

28:30 Bryan Johnson Blueprint uselessness

32:54 Interest rates affecting Funding and activity for startups and SENS  (FQ)

35:30 Purpose of interest rates 

38:00 SENS Research foundation weathering changes / Aubrey De Grey / Funding 

38:45 Andrei Gudkov Roswell institute / Retrotransposons Research

41:10 Projects at SENS research foundation / Jean Herbert Replacing neurons 

43:59 Amit Sharma / Antibodies targeting Tau / Project Designed by Aubrey de Grey 

47:40 Sharma Lab / Senescent cell killer project

49:50 Amutha Boominathan / Mitosense project

51:45 Longevity applied to healthspan and quality of life 

54:10 Potential Therapies for Alzhiemers disease

57:00 Thoughts on Regeneration / Combination therapies / LEV & Aubrey de Grey new approach

01:01:05 New project Abdelhadi Rebbaa Iron metabolism project 

01:05:35 Gender differences on iron impact

01:07:15 SENS research projects skipping metabolism to target problem directly 

01:13:40 Future of economy and society with longevity 

 01:16:55 His life in that post longevity world

01:20:35 Book recommendations 

01:24:45 Timeline for Aubrey De Grey’s LEV

01:26:25 Groups to support in longevity