In this podcast, we focus on some of the significant trial updates presented at the congress. We shall hear from Francesco Cortiula, MD, University Hospital of Udine, Udine, Italy, and Maastricht University Medical Center, Maastricht, Netherlands, Luca Nicosia, MD, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Italy, Tiuri Kroese, MD, University Medical Center Utrecht, Utrecht, Netherlands, Pedro Lara, MD, PhD, Fernando Pessoa Canarias University and San Roque University Hospital, Gran Canarias, Spain, and David Dearnaley, MA, MD, FRCP, FRCR, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.