In this episode of the IJGC podcast, Editor-in-Chief, Dr. Pedro Ramirez, is joined by Dr. Emma Crosbie to discuss urine cytology in detection of endometrial cancer. Dr. Crosbie is an NIHR Advanced Fellow, Professor and Honorary Consultant in Gynaecological Oncology at the University of Manchester. Her research focuses on screening, prevention and early detection of gynaecological cancer.

Highlights:

• Current diagnostics for endometrial cancer are poorly tolerated by some, painful for others and unnecessary for most because only 5-10% of women with postmenopausal bleeding have endometrial cancer

• This proof-of-concept study showed that endometrial cancer cells can be collected from the urogenital tract using non-invasive sampling technologies and detected by cytology

• If confirmed in larger studies, this concept could form the basis of a simple, pain-free, easily administered test with potential for rapid, same day results to triage women for urgent investigation of suspected endometrial cancer, whilst safely reassuring healthy women

• Such a test could substantially reduce the psychological, physical and financial burden of the current diagnostic pathway for endometrial cancer