Already, vaccines prevent millions of premature deaths and avoid bothersome days of sickness each year. Now, during the COVID-19 pandemic, vaccines have again risen to the level of headlines, conspiracy theories, and active research. During this session, we will discuss the mechanisms and means of appropriately vaccinating patients, review ethical and social concerns about vaccines, identify sources of appropriate vaccination information and administration for international travelers, and provide updated information about the development of COVID-19 vaccines.