VAT Trap

VAT Trap

By Dr Edward LeathamMedicineHealth & FitnessFitness
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VAT Trap episodes

  • What Keto and Atkins Diets Do

    Multiple studies show that low-carb, high-fat diets tend to shift LDL particles toward larger, more buoyant LDL (pattern A).
    These particles are considered less atherogenic than small, dense LDL (pattern B), typical of insulin resistance.

    Therefore, while LDL-C concentration may rise, LDL particle number (apoB) or non-HDL cholesterol may not rise proportionally — and inflammation markers (hs-CRP, TG/HDL ratio) often fall.


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    13 min
  • MASLD/MASH -metabolic dysfunction -associated steatotic liver disease: What You Need to Know

    MASLD is a silent but important marker of metabolic health and another consequence of raised Visceral Adipose Tissue (VAT). Although often discovered by chance, it carries significant implications for both liver and cardiovascular wellbeing. Through caloric restriction, physical activity, improved nutrition, and early intervention, MASLD can usually be stabilised or reversed — protecting not just the liver, but the heart as well.

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    13 min
  • Cholesterol, LDL, and what we learnt from PCSK9 mutations in familial hypercholesterolaemia

    In families with inherited high cholesterol (familial hypercholesterolaemia), mutations in the PCSK9 gene have been identified which make this protein overactive. These are known as gain-of-function mutations — they increase PCSK9 activity and push LDL cholesterol to dangerous levels. For over 90% of people with raised LDL who do NOT have a mutation, there are alternative explanations outlined in a related article and for  readers that are curious about this PCSK9 take a look at my technical article linked to the VAT Trap book series on LDL Cholesterol. Read blog

    19 min
  • So what does determine your LDL (‘bad’) Cholesterol?

    In the first podcast in the series, the discussion revolves around cholesterol and the fact that while your blood LDL cholesterol determines the development of coronary plaque, your levels are more about your genetics than necessarily what you eat. In contrast, what happens to coronary plaque over your lifetime and whether it causes a heart attack is more about 'inflammation',  what carbohydrates and UPF's you eat and your lifestyle.

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    10 min

About VAT Trap

From the publisher's feed

The VAT Trap book, blog and digital media series reveals how visceral fat — the hidden metabolic organ — drives heart disease, hypertension, and diabetes. Drawing on 30 years of frontline cardiology and the latest in imaging, app-based tracking, and metabolic science, Dr Ed Leatham translates complex research into clear, actionable steps. Whether you want to avoid heart disease, stabilise your metabolism, or understand GLP-1 therapy, these four concise podcast seasons accompany a four book series that will help you see, track, and reverse the VAT trap.