Today we break down the pharmacology that every man should know. Sildenafil and tadalafil belong to the same class of medications, but they behave very differently. We cover the evolutionary path from early cardiovascular research to the discovery of Viagra, the development of tadalafil as a long acting PDE5 inhibitor, and the receptor selectivity that explains their unique profiles.

You will learn how onset time, half life, peak action, and PDE subtype binding affect your sexual performance. We also explain why many men unintentionally mismatch the medication to the situation, and how to choose the right drug with purpose instead of guessing.