A biotech revolution is taking root in Virginia, and we brought in someone who’s building it from the inside. Sally Allain—Chief Health Science Growth and Innovation Officer at Virginia Tech and a double Hokie—shares how a career that began with undergraduate research evolved into leading global collaborations at Johnson & Johnson, launching JLABS in DC, and now accelerating translation and industry partnerships across the Commonwealth.

We dig into how a medicine actually gets made, from picking a target in the lab to surviving toxicology, raising venture capital, filing the IND, and navigating clinical trials. Sally breaks down the “valley of death” that stalls promising science and how smart alliances, philanthropic support, and experienced operators can close the gap. Along the way, we explore how Roanoke’s Fralin Biomedical Research Institute is reshaping the region’s identity with physician‑scientist hires, a state‑backed Patient Research Center in oncology, neuroscience, and cardiovascular disease, and a plan with Children’s National to bring small‑scale GMP cell and gene therapy manufacturing to Southwest Virginia.

Zooming out, we connect the dots between AstraZeneca, Eli Lilly, and Merck’s major investments; Virginia Tech’s strengths in engineering, robotics, and AI; and the growing Mid‑Atlantic corridor that stretches from Washington to Roanoke and links into North Carolina. The result is a clearer picture of what it takes to convert academic breakthroughs into therapies, jobs, and regional growth—plus real steps for building a workforce pipeline that keeps graduates in the Commonwealth. If you’re curious about how ideas become medicines and why Virginia is suddenly on the pharma map, this conversation brings strategy, science, and urgency together.

Enjoyed the show? Follow, rate, and share with a friend who loves science, startups, or Virginia’s future. Your review helps more listeners discover these stories.

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Want a front‑row seat to how Virginia plans to stay a top state for talent? We bring in former Speaker of the House and VBHEC president Kirk Cox to connect the dots between policy, campuses, and paychecks. From the first spark of a career in high school to paid internships that flip underemployment on its head, this conversation lays out a concrete roadmap for students, families, and employers who want results, not buzzwords.

Kirk explains why the Virginia Business Higher Education Council is uniquely positioned to make change—its board blends all 16 public university presidents, private colleges, the community college system, and CEOs under one roof. We dig into the Impact Agenda’s four pillars: talent pathways and internships, affordability and ROI, innovation and entrepreneurship, and solving local problems through regional partnerships. Expect real examples, like ODU’s one‑stop internship hub, the Blue Ridge Partnership’s healthcare pathways, and FastForward credentials that put adult learners back on track after years away from school. We also get honest about the budget: how to protect key investments, why Virginia’s state support lags peer leaders, and what ROI data shows about the billions higher education contributes to jobs and growth.

The episode also tackles the future of work head‑on. AI is changing entry‑level tasks, but it’s also opening doors in healthcare, engineering, and data‑driven fields—making hands‑on internships and human skills more valuable than ever. We talk “universities without borders,” interdisciplinary learning that breaks silos, and flexible models that meet regional demand without pigeonholing campuses. If you care about paid internships, tuition you can afford, and pathways that actually lead somewhere, you’ll leave with practical insights and a clearer view of how Virginia can scale what works. Listen, share with a friend, and tell us the one change you think would move the talent needle most—then hit follow so you don’t miss what comes next.

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Step into the pews where a colony weighed its future. We bring you inside St. John’s Church in Richmond for a gripping walk-through of the Second Virginia Convention, the razor-thin voice vote to arm a militia, and the eight-minute speech that helped turn a crisis into a revolution. Patrick Henry’s words didn’t just stir Virginia; they traveled across centuries and borders, inspiring people facing censorship and fear to risk speaking out.

Stephen Wilson, executive director of the St. John’s Church Foundation, maps the road from the Boston Tea Party to March 1775, explaining why the church—then the largest building west of Williamsburg—became the stage for a defining choice. He lays out who stood where: Washington, Jefferson, Richard Henry Lee, Nelson, and the loyalist heavyweights who argued for caution. We also get rare context on the speech’s origins, how biographer William Wirt reconstructed it, and why the vote’s narrow margin still shocks audiences. Along the way, you’ll hear a powerful live excerpt that puts you back in the room.

Kefu Huang shares a moving personal story linking “Give me liberty or give me death” to Tiananmen and the more recent white-paper protests, underscoring how liberty is both fragile and worth the cost. Then we shift from history to how you can experience it: immersive Liberty or Death reenactments, behind-the-scenes evenings with bell ringing and under-church tours, and a robust speaker series that has drawn voices from Pulitzer winners to governors. Stephen also highlights the Foundation’s preservation mission—cemetery care, stained glass repairs—and how individual support keeps this independent site alive.

If you love American Revolution history, public history experiences, or simply want to stand where courage changed the course, this conversation will move St. John’s Church to the top of your list. Stream the episode, watch the full reenactment online, and plan your visit. If the story resonates, subscribe, share the show with a friend, and leave a review so more listeners can find it.

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A leaking steamship. A silent mosquito. And a summer that rewrote the map of fear along the Elizabeth River. We sit down with author and veteran journalist Lon Wagner to uncover the 1855 yellow fever outbreak that ravaged Portsmouth and Norfolk—and somehow faded from local memory. What begins with a “rat lady” explaining vector control becomes a gripping true story of a captain’s denials, a health system built on miasma theory, and a minister’s meticulous letters that tracked the spread long before germ theory took hold.

Lon takes us aboard the Benjamin Franklin, a ship detouring from St. Thomas with sickness in its wake, and into the crowded Irish tenements of Barry’s Row where proximity and poverty turned risk into catastrophe. We explore the misguided remedies—tar barrels, lime-dusted streets, towering wooden walls—and the human calculus of who fled, who stayed, and who served as the city’s nerves frayed. Along the way, we draw clear lines to our present: Aedes aegypti still thrives; dengue, Zika, and West Nile still surface; and the tension between public health and commerce is as old as the docks themselves.

This is a story about vectors and victims, but also about memory and readiness. Lon’s book, The Fever, restores names, places, and decisions to a crisis that once commanded national headlines. If you care about how cities actually work in a crisis—movement, communication, trust, and the physics of spread—you’ll find hard-won lessons here, told with empathy and detail. Press play, then tell a friend, and if the conversation hits home, subscribe, leave a review, and share your biggest takeaway so more people can find this story before the next one arrives.

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What happens when a coal miner's daughter from Virginia's mountains becomes a college president? Dr. Debbie Sydow's remarkable journey reveals how education transforms lives and how she's working to ensure others have the same opportunities that changed her trajectory.

Growing up in Wise County with coal miners, moonshiners, and preachers for family, Dr. Sydow's path shifted when a teacher intervened, encouraging her to pursue college preparatory courses instead of vocational training. This seemingly small act altered her entire future, demonstrating the power of mentorship that would become central to her educational philosophy.

Dr. Sydow takes listeners through Virginia's fascinating higher education history, explaining the surprising connections between universities across the Commonwealth. Richard Bland College emerges as a unique institution – the last college to gain independence from William & Mary's governance and still under a Supreme Court injunction preventing it from offering four-year degrees despite dramatic changes in demographics since the civil rights era.

The conversation illuminates Richard Bland's distinctive position in Virginia's educational landscape as a "university parallel" institution. Unlike community colleges, it offers a residential campus experience with full-time faculty holding terminal degrees, yet remains more affordable than four-year universities. Dr. Sydow explains how this model provides crucial scaffolding for students who need additional support, particularly first-generation college attendees.

Most compelling is Dr. Sydow's vision for the future – from innovative partnerships with drone technology companies to a business innovation park designed to provide on-campus internships for every student. She articulates how artificial intelligence might revolutionize education by customizing learning experiences while preserving the essential human connection between teacher and student.

As she prepares for retirement after 14 years at Richard Bland's helm, Dr. Sydow reflects on what drives her: giving students from backgrounds like hers the opportunity to broaden their horizons and dream bigger dreams. Her story reminds us that higher education's true purpose isn't just conferring degrees but transforming lives and communities.

Listen to this episode to understand how Virginia's educational past shapes its present, and how leaders like Dr. Sydow are working to ensure its future serves all Virginians, regardless of their zip code or circumstances.

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Could the future of healthcare lie in our past? Dr. Priyanka Lisbeth thinks so. As a house call physician with Harmony Cares, she's bringing back a practice many thought was confined to history books – and revolutionizing care for our most vulnerable populations in the process.

When patients enter a doctor's office, they present their "best selves" – dressed, prepared, and often masking the daily struggles they face at home. Dr. Lisbeth discovered that seeing patients where they live reveals crucial details traditional clinical settings miss. Are they actually taking those 12 daily medications correctly? Can they navigate their home safely? What truly matters to them beyond medical metrics?

America faces an unprecedented demographic shift. By 2040, one in five Americans will be over 65, creating demands our healthcare infrastructure isn't equipped to handle. The current volume-based system – focused on procedures, visits, and codes – fails to address what Dr. Lisbeth calls the "three critical challenges": access, affordability, and equity.

Through compelling patient stories, Dr. Lisbeth illustrates how house calls transform healthcare delivery. She spends 30-45 minutes with each patient, helping manage complex medication regimens, assessing home environments, and coordinating specialist care. For elderly patients with mobility issues, visual impairments, or cognitive challenges, this approach prevents hospitalizations and improves quality of life.

Beyond the practical benefits, Dr. Lisbeth finds profound meaning witnessing what she calls "that forever kind of love" between elderly couples facing health challenges together. Her beautifully vulnerable essay "The Big Love" captures why medicine must reconnect with its human core.

As we navigate our own aging journeys, Dr. Lisbeth offers three powerful insights: maintain physical activity ("don't give up, get up"), combat social isolation through community connections, and find purpose in serving others – regardless of how small those contributions might seem.

The revival of house call medicine represents more than nostalgia; it's a practical response to our healthcare system's limitations. By focusing on what truly matters to patients, physicians like Dr. Lisbeth help medicine return to its roots while embracing innovative models for our future.

Ready to rethink everything you thought you knew about healthcare delivery? Listen now and discover why sometimes, moving forward means looking back.

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Standing in Thomas Jefferson's bedroom at Monticello, hearing how both he and John Adams died on July 4th, 1826—exactly 50 years after American independence—creates a moment where you don't just learn history but feel it viscerally. This "power of place" forms the heart of Virginia's approach to commemorating America's 250th anniversary.

Cheryl Wilson, Executive Director of Virginia's America 250 Commission, reveals how the Commonwealth is orchestrating a statewide celebration honoring Virginia's pivotal role in founding our nation. Unlike traditional historical commemorations, Virginia's approach weaves together past and present, connecting revolutionary principles to our ongoing work of forming "a more perfect union."

The Commission's collaborative structure reflects Virginia's inclusive vision, with advisory councils ensuring African American and Tribal Nations' perspectives are represented. All 134 localities across Virginia have established their own 250th commissions, creating a grassroots network that's already planned over 1,700 events. From a mobile museum traveling to schools to commemorative ceremonies at St. John's Church and Colonial Williamsburg, these initiatives make history accessible to all Virginians.

Most compelling is how Virginia has launched initiatives that transcend state boundaries. The "Two Lights for Tomorrow" movement—inspired by Paul Revere's famous signal—began as a small Virginia Commission idea and grew into an international phenomenon, with twin lights appearing everywhere from statehouses to the International Space Station, symbolizing our shared commitment to America's founding principles.

Visit va250.org to discover upcoming events, sign up for newsletters, and learn how you can participate in this historic commemoration. As we approach July 4th, 2026, join us in experiencing the places where American independence was conceived, declared, and ultimately won—right here in Virginia.

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What happens when you take a lifelong Virginian with experience in both Democratic and Republican administrations and ask him about the biggest challenges facing the Commonwealth? Grant Neely delivers a masterclass in crossing political divides to solve real problems.

Neely's journey began in Henrico County during the post-busing era, where attending a diverse public high school taught him to connect with people unlike himself. This foundation served him well as he moved through careers in politics, government, and corporate America before returning to his beloved Virginia. With experiences ranging from Mark Warner's gubernatorial campaign to serving as Richmond Mayor Dwight Jones' chief of staff, Neely brings a unique perspective on how government can work effectively across partisan lines.

Now focused on systemic reform, Neely is tackling Virginia's foster care crisis head-on. The stark contrast is jarring: Virginia ranks as the best state for business while simultaneously ranking 47th-49th for outcomes of children aging out of foster care. Through the Virginia Children's Partnership, he's bringing business-minded efficiency and accountability to a fragmented system, while maintaining the humility to learn from those who've dedicated their lives to this work. "We deserve better," he insists, outlining a 10-year strategy to transform how Virginia supports its most vulnerable children.

Equally passionate about Virginia's educational heritage, Neely partners with Virginia Union University—an HBCU with origins in a former slave jail that now stands as a testament to resilience and opportunity. As the university expands its reach through innovative programs and property development, it builds on 160 years of history while securing its future for generations to come.

Perhaps most refreshing is Neely's call for civility in our public discourse. In an age of algorithmic outrage and partisan entrenchment, he reminds us that solving real problems requires coming together across political divides. "If my starting point is I'm right and you're wrong," he warns, "it's a small step to 'I must eliminate you.'" Instead, he suggests focusing on common challenges that affect all Virginians.

Ready to move beyond the politics of division? Listen now to discover how civility, competence, and compassion can transform Virginia's toughest challenges into opportunities for meaningful change.

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When Dwayne Yancey founded Cardinal News four years ago, he never imagined how quickly it would transform Virginia's media landscape. What began as a modest effort to fill the void left by shrinking newspapers in Southwest and Southside Virginia has blossomed into a vital statewide news source with ten reporters and an audience extending far beyond its coverage area.

"We blew past our five-year goals in 18 months," Yancey reveals, explaining how readers in Richmond and Northern Virginia regularly follow Cardinal News despite its regional focus. When asked why they're interested in coverage of areas far from their homes, these readers consistently respond, "You're telling us about a part of the state we know nothing about." This bridge-building function represents perhaps Cardinal's most unexpected achievement—connecting Virginians across regional divides through authentic, nuanced storytelling.

The conversation weaves through several compelling narratives of rural Virginia's transformation. Danville emerges as a powerful success story, rebuilding its once-collapsed textile economy through advanced manufacturing and now attracting more new residents than much larger cities. Similarly, the impact of the Virginia Tobacco Commission's investments in broadband and education have fundamentally altered the trajectory of previously struggling regions, proving that strategic public investment can catalyze genuine economic rebirth.

Politically, Virginia reflects the national trend toward polarization, with Yancey lamenting the disappearance of figures like former Delegate Barney Day—a "conservative Democrat" from Patrick County whose authentic, independent voice would struggle to find a place in either party today. Looking ahead to the historic gubernatorial race between Winsome Sears and Abigail Spanberger, Yancey offers insights into how national politics increasingly overshadow state issues, with candidates navigating complex dynamics around President Trump's influence and Virginia's history of voting against the party in the White House.

As traditional newspapers continue their decline "for the same reason vinyl records and 8-track tapes declined," Yancey remains cautiously optimistic about journalism's future. The rise of nonprofit news sites across America suggests a new model is emerging—one focused on quality reporting rather than opinion, delivering news how and when readers want it. Subscribe to our newsletter at cardinalmuseorg to follow this evolution in Virginia journalism and join our growing community of engaged readers.

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What if America's founders were right all along about divided government? As our nation approaches its 250th birthday amid unprecedented polarization, Virginia might hold the blueprint for making democracy work again.

Frank Atkinson, attorney, author, and veteran of both the Reagan administration and Virginia politics, takes us on a fascinating journey through the Commonwealth's political evolution. With remarkable clarity, he reveals how Virginia—the cradle of American democracy—has become a laboratory for successful divided government in modern times.

Drawing from his forthcoming book and decades of firsthand experience, Atkinson argues that Virginia's competitive two-party system has produced better outcomes than one-party dominance. Since 2000, no state has experienced more divided government than Virginia, creating a political environment where collaboration isn't just desired—it's required.

The conversation explores transformational figures who shaped Virginia's political landscape: Mills Godwin, who served as governor as both Democrat and Republican; the populist firebrand Henry Howell; and George Allen, whose policy-driven governorship succeeded despite facing a Democrat-controlled legislature. Through these stories, Atkinson illuminates how Virginia managed to implement major reforms through bipartisan cooperation.

Perhaps most remarkably, even after court-ordered redistricting created entirely new legislative districts in 2023, Virginia's elections resulted in extraordinarily narrow margins—51-49 in the House and 21-19 in the Senate. This persistent competitiveness defies the national trend toward partisan entrenchment.

Atkinson doesn't paint an idealized picture. He acknowledges the challenges of redistricting, geographic sorting of voters along partisan lines, and the nationalization of state politics. Yet he maintains that Virginia's experience offers hope that divided government can foster the compromise and problem-solving that seems increasingly elusive at the national level.

As we struggle to overcome deadlock and dysfunction in Washington, this conversation offers a compelling vision for how our democratic system—when functioning as the founders intended—can still deliver results even amid fierce partisan competition. Listen and discover why Virginia's political model might just be what America needs in its next quarter millennium.

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