In our first episode of season one, Patrick Ryan, PhD, VP Observational Health Data Analytics, Janssen R&D, Assistant Professor, Adjunct; Department of Biomedical Informatics, Columbia University Medical Center, and founding member of Observational Health Data Sciences & Informatics (OHDSI) joins us to discuss the last decade of OHDSI's and now EHDEN's methodological and tool development. We expand into COVID-19 and the pandemic's impact on observational research, and conclude by discussing OHDSI's educational remit and the need for upskilling in the research community.