2022 Project Promotions

Wego_Taipei: Eutro in Vitro (2022) - Project Promotion [English]


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Title: Eutro in Vitro

Description: In various water bodies, the overabundance of nutrients from agriculture chemicals, including fertilizers (nitrogen and phosphorus) and biocides (herbicides, fungicides, and insecticides), resulted in the process of eutrophication. The increase of phosphate and nitrogen amounts leads to algal bloom followed by the decline in sustainability of lives in the water bodies. The physical and chemical solutions that currently exist are less stable and could potentially disturb the ecosystem. Our project presents a new method to solve the issue of eutrophication from its roots. By engineering bacteria that overexpress organophosphorus hydrolase (OPH) and antisense PhoU RNA, we can hydrolyze organic phosphates into inorganic phosphate (Pi) for biocides detoxification, enhance the efficacy of Pi transport, fix the excess of Pi into polyphosphate (polyP), respectively. The implementation of a filtering device containing the engineered bacteria with biosensors could reduce phosphate levels in water bodies to ultimately prevent the cycle of eutrophication.In various water bodies, the overabundance of nutrients from agriculture chemicals, including fertilizers (nitrogen and phosphorus) and biocides (herbicides, fungicides, and insecticides), resulted in the process of eutrophication. The increase of phosphate and nitrogen amounts leads to algal bloom followed by the decline in sustainability of lives in the water bodies. The physical and chemical solutions that currently exist are less stable and could potentially disturb the ecosystem. Our project presents a new method to solve the issue of eutrophication from its roots. By engineering bacteria that over-express organophosphorus hydrolase (OPH) and antisense PhoU RNA, we can hydrolyze organic phosphates into inorganic phosphate (Pi) for biocides detoxification, enhance the efficacy of Pi transport, fix the excess of Pi into polyphosphate (polyP), respectively. The implementation of a filtering device containing the engineered bacteria with biosensors could reduce phosphate levels in water bodies to ultimately prevent the cycle of eutrophication.

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