Six-year-old Marley Nicholls has bone marrow failure. He has been given just three years to live, unless a suitable donor can be found.

After a horrific coach crash, Catrin Pugh suffered burns to 96% of her body. Given just a one in a thousand chance of survival, not only did she survive but has become a campaigner for body positivity.

Settling in Cardiff from India during the 1970's, Meena Upadhyaya overcame discrimination to become a world-leading scientist.

Her pioneering work in genetics has shed new light on diseases affecting people all over the world.

David Wilson was 18 years old when a motorcycle accident left him paralysed from the neck down. On his long road to recovery, his passion for photography gave him a purpose and a reason to keep going during his darkest moments.

At 101 years of age, Ron Jones has much to mull over.

As a prisoner of war during World War II, he witnessed first-hand the horrors of Auschwitz, endured a brutal death march and lived to tell the tale.

Shaun Stocker's life changed forever when he was just nineteen years old. A frontline soldier, he was on a tour of Afghanistan when he stepped on a bomb planted by the Taliban - losing both his legs.

Eight years later, he's determined to swap the pain of the past for a brighter future.