On this week's episode, we explore the ins and outs of chronic spontaneous urticaria. We discuss the signs, symptoms, complications, and how-it-works of the disease, including how linchpin molecules in the cell like Bruton's tyrosine kinase may be the key to tempering extreme reposnses from a hair-trigger immune system.

References:

Isachenkov, V. (2017, September 19). Stanislav Petrov, who averted nuclear war, dies at 77. The Associated Press. https://apnews.com/general-news-b9de4e3c9a5949e4a27e8ea601059f25

Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al (2022) The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy; 77:734-6. https://onlinelibrary.wiley.com/doi/full/10.1111/all.15090

Gonçalo, M., Gimenéz‐Arnau, A., Al‐Ahmad, M., Ben‐Shoshan, M., Bernstein, J. A., Ensina, L. F., ... & Maurer, M. (2021). The global burden of chronic urticaria for the patient and society. British Journal of Dermatology, 184(2), 226-236. https://doi.org/10.1111/bjd.19561

Jain V, Giménez-Arnau A, Hayama K, et al (2024) Remibrutinib demonstrates favorable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks. J Allergy Clin Immunol; 153(2):479-86 https://doi.org/10.1016/j.jaci.2023.10.007

Balp, M.M., Halliday, A.C., Severin, T, et al (2022). Clinical remission of chronic spontaneous urticaria (CSU): A Targeted Literature Review. Dermatol Ther (Heidelb). Jan;12(1):15-27. https://link.springer.com/article/10.1007/s13555-021-00641-6

Saini SS, Kaplan AP (2018) Chronic Spontaneous Urticaria: The Devil's Itch. J Allergy Clin Immunol Pract; 6(4):1097-106. https://doi.org/10.1016/j.jaip.2018.04.013