This study demonstrates how the plant pathogenic bacterium Pseudomonas syringae manipulates the cellular machinery of plants to promote infection. Researchers discovered that specific bacterial effectors, HopM1 and HopN1, trigger the formation of processing bodies (P-bodies) to suppress the synthesis of host immunity-related proteins. This translational repression process requires inhibition of the endoplasmic reticulum stress response and activation of autophagy to recycle cellular components. By stabilizing these biomolecular condensates, the pathogen is able to neutralize plant defenses at the post-transcriptional level. These findings reveal a previously unknown link between protein homeostasis, messenger RNA regulation, and bacterial virulence.

https://www.science.org/doi/10.1126/sciadv.aec4477