Rejuvenate Your Hormones and Wellness

Why Estradiol Isn't Always the Answer in Perimenopause


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Hi, I'm Colleen Kupka, hormone specialist and founder of Rejuvenate Hormone and Weightloss Center in Scottsdale, Arizona.

In this episode, I'm sharing a story I hear far too often: a woman in perimenopause, feeling overwhelmed, confused by her lab results, and convinced that estradiol is the fix.

But when we're in this phase, our hormones—especially estradiol—fluctuate dramatically, sometimes even doubling from one day to the next. Relying on lab numbers alone can actually lead to bigger problems, not solutions.

Dive in with me as I explain:

  • Why estradiol can be risky in perimenopause
  • The critical role progesterone plays in calming symptoms like anxiety, brain fog, and insomnia
  • Why symptoms—not just labs—should guide your care
  • The truth about bioidentical hormone therapy
  • & why working with a real provider (not just AI) matters for long-term wellness

Whether you're in Scottsdale or anywhere else, my goal is to help you feel seen, heard, and supported. Hormone therapy isn't one-size-fits-all—and you deserve personalized care based on what your body is really telling you.

Ready for real answers from a real person? Schedule your consultation with me today or give me a call at 480-589-3999.

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Rejuvenate Your Hormones and WellnessBy Colleen Power Kupka