Ep. 78: Why Maximizing Energy Production and Minimizing Stress Is Optimal For Health (Hormesis Part 4)

In this episode we discuss:

How you can induce mitochondrial biogenesis and uncoupling without stress

Why you want tighter mitochondrial coupling if you want to induce uncoupling in a healthy way

The difference between reactive oxygen species production in a high energy state versus a low energy state

How many supposedly hormetic interventions, like exercise, fasting, and ketogenic diets, can be beneficial despite the stress they cause rather than because of it

How the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view

What anti-hormesis looks like in a practical sense

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Click here to check out the show notes: https://jayfeldmanwellness.com/ep-78-why-maximizing-energy-production-and-minimizing-stress-is-optimal-for-health-hormesis-part-4/ 

Timestamps:

3:22 – the difference between producing ROS in a high energy state compared to a low energy state  

9:38 – how ATP protects against oxidative stress

21:55 – how CO2 protects against oxidative stress

26:31 – how tighter mitochondrial coupling is better for inducing uncoupling

27:48 – the broader context of why we want to adapt to a high-energy, low-stress state 

33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it

47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it

57:40 – what to expect when moving away from a hormetic approach 

1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view 

1:03:39 – what anti-hormesis looks like in a practical sense