Fullscript for WiseAthletes

Intense exercise takes a biochemical toll. Research has shown that intense activity results in decreased levels of glutathione, our body’s homemade master antioxidant. And, that happens even when you start the day with enough glutathione despite the naturally declining levels found in the older athlete.  Without sufficient glutathione, the oxidative stress associated with exercise can reduce athletic performance and delay recovery.   Heck, low glutathione can make you look and feel old.

Today we have invited Ross Pelton the Natural Pharmacist to educate us about Glutathione, the master antioxidant and a key biomarker of aging. Glutathione is made by the body to act as the master regulator of other antioxidants....when you have enough glutathione, your body can make or recycle all the antioxidants it needs. What's more, low glutathione is a marker for aging and a higher likelihood of disease. The older we get, the less glutathione our bodies make, and the more glutathione our bodies need.  Glutathione IV drips are all the rage these days, but do we need it?

Ross is the Natural Pharmacist and his website, bio and blog are at naturalpharmacist.net. He is passionate about life extension and anti-aging science and technology. He has written 12 books including “Rapamycin, mTOR, Autophagy & Treating mTOR Syndrome” and in 1999, he was named one of the Top 50 Most Influential Pharmacists in the U.S. by American Druggist magazine

The Critical Roles of Glutathione

A few of the benefits an athlete can expect from glutathione.

Considering how important glutathione is to health, researchers have looked for ways to increase intracellular and intramitochondrial levels. Here are the effective approaches:

Fullscript for WiseAthletes

For centuries the search for eternal youth or elongated life has been a frequent topic of various myths and legends from around the world.  Adventurers looked in far away lands for clues to the healing waters. In modern times, pharmaceutical companies hunted in jungles and tropical islands for exotic molecules that could be used to solve human disease. Now Ora Biomedical is searching among chemicals and combinations of chemicals laying in plain sight for clues to massive life (and health) extension. And now you can participate by sponsoring a compound that you know or just think is worth $100 to take a look.

Today we are talking with Mitchell Lee, PhD about Ora Biomedical's Million Molecule Challenge and its new citizen science fundraising approach that allows everyone to participate in completing the moonshot Million-Molecule Challenge (assess 1,000,000 longevity interventions in 5 years vs. just under 1,100 compounds tested so far by modern science). In addition, Dr Lee and I discuss my question of how to be "bold but safe" regarding the high-wire act of using off-label pharmaceuticals and OTC nutritional supplements to get a fast start (i.e., start now) on the pursuit of extended human healthspan. This question has been burning my brain as I personally search for a path that avoids the slippery slope of wishful thinking, marketing overpromises (lies) and the dangers of combining too many powerful chemicals.

From Ora Biomedical's website: "...from a small pilot screen of a few mTOR inhibitors, Ora has already identified one that works better than rapamycin....our preliminary data lead us to believe that combinations of 2-5 different longevity interventions have the potential to be twice to ten times as effective as the current best-in-class."

If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes.

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Dr Lee received his PhD in Experimental Pathology from the University of Washington School of Medicine, where he trained with Matt Kaeberlein . He is the Co-founder and CEO of Ora Biomedical, a new

...it's a fool's errand to try and make older people young. But it's enormously fun to try and make older people fast. That's fun. And it's very good for you, almost certainly. And, do the work; shortcuts tend not to turn out very well or for very long in older athletes.

The better cyclist you want to be past 50, the more you probably have to drop cycling sessions out and put something else in to compensate. So you probably need to drop a cycling session now and put in a gym session, or a running session, or some other sport to work on bone density and muscle fibre loss. So it's a counterintuitive thing. The more you cycle and the more you seek cycling performance, the more you probably need to cast your net a bit wider. Sometimes you need to slow down to go fast.

Phil Cavell is the author of The Midlife Cyclist', a book for the 40+-year-old cyclists who want to train hard, ride fast and stay healthy. It's less of a how-to and more of a philosophy of the older athlete...a collection thoughts and ramblings. It's what you’d talk about with a doctor friend who knew everything about the body and cycling the bike. 

Phil says to stop by Cycle Fit to say hello if you are ever in London. I know I will.

Phil Cavell is the CEO of the London-based bike fitting studio, Cycle Fit. As well as being an expert on the biomechanics of cycling, Phil has recently written 'The Midlife Cyclist', a book for the 40+-year-old cyclists who want to train hard, ride fast and stay healthy.

If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes.

And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES

Thanks.

A healthy athlete is a strong athlete, and athletic longevity requires a long life. To achieve our athletic longevity goals, almost all of us resort to the optimistic usage of pills and powders.

One of the major bummers for the older athlete, is that no one knows how to make people younger.  All we can do is slow down the rate of aging.  The healthier we are, the slower we age….meaning the more slowly we progress toward that visit to the pearly gates. 

How can we balance risk and reward, prioritize which interventions to pursue first, how to tell is we are getting a positive or negative result from our interventions including pharmaceuticals and nutritional supplements. These are the questions answered by Daniel and Rick, who also share their thoughts about Rapamycin dosing, cycling interventions to restore beneficial cycles of growth and autophagy, and how Healthspan is delivering a platform to help clients to set proper goals and stay on course over time including taking corrective action when interventions (type and dose) don't deliver results.

Dr. Rick Cohen, M.D. is a leading authority in the fields of nutrition, sports performance and longevity medicine. He received his undergraduate degree in Biomedical Engineering with honors of distinction from Duke University in Durham, North Carolina and his medical degree from Hahnemann Medical University in Philadelphia, Pennsylvania. Rick is also a leader in the field of male functional hormone health and the author of the book “Be All the Man You Can Be” with over 100k copies sold in the past five years. 

Daniel Tawfik is the founder, developer, and CEO of HealthSpan. Daniel holds a BS degree from UCLA in molecular, cellular, and developmental biology and physics. Daniel did his graduate research at UCLA's Protein Expression Technology Center where he studied neurometabolic disorders.

If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes.

And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES

Thanks.

Today we are talking about one particular aspect of acquiring and retaining healthiness:  the chemicals we put into our bodies.  Chemicals include:  pharmaceuticals, botanicals, herbs, spices, concentrated foods, vitamins, minerals.   Today, we are NOT going to talk about specific recommendations for specific chemicals…rather we are going to discuss how to think about using chemicals in a way that is safe and responsible, while also bein

Moringa is known as the miracle tree because of its many beneficial features, which include: it helps to increase the blood antioxidants and reduce the blood sugar as well as chronic inflammation. It provides 7 times more vitamin C than oranges, 10 times more vitamin A than carrots, 17 times more calcium than milk, 9 times more protein than yoghurt, 15 times more potassium than bananas, and 25 times more iron than spinach.  Rightly so it is on everybody’s superfood list because Moringa truly is a miracle tree.

While working with women farmers in Niger, Kuli Kuli’s founder Lisa Curtis was introduced to the energizing and healing powers of Moringa. Out of that experience, Lisa dreamed of a business that would help Americans experience the power of superfoods like Moringa while empowering female farmers around the world. Out of that dream, Kuli Kuli was born.

Dr. Fahey is THE INTERNET FAMOUS nutritional biochemist with extensive background in plant and human nutrition and phytochemistry.

If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes.

And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES

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I'm sure you've heard something, somewhere about magnetic field therapies providing pain and healing through noninvasive anti-inflammatory effects. To my ears, this all sounded a little too much like those X-Ray glasses that I ordered in 1975 that never arrived. Today I am talking with Bob Dennis, PhD, Professor of Biomedical Engineering at the University of North Carolina at Chapel Hill, and Founder of Micro-Pulse, about his work with NASA on PEMF and his pursuit of a non-drug solution to his own back pain. Bob is a scientist and an old-school tinkerer on a mission to bring affordable PEMF technology to Wise Athletes and people in pain everywhere.

The original NASA TVEMF - PEMF systems were developed by Dr. Robert Dennis for NASA under contract in 1997 - 1998.  Recently corrected NASA patents verify his status as original inventor.  Four additional patents (1 2 3 4) demonstrate the recent advances that have been made since the original work at NASA, leading to modern ICES® DigiCeutical® technology developed in 2013 - 2014.  ICES is the new PEMF.

Founded by Dr. Robert Dennis (LinkedIn profile) to provide biomedical technology research & development to bridge the gap from academic research to industry, Micro-Pulse LLC has evolved into an independent core technology origination company for a wide range of products, including specialized test apparatus for basic scientific research, robust products for military applications, and low-cost high-performance commercial products for medicine, research, and education.

Bob Dennis is a Professor of Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a medical scientist and tissue engineer, and consultant in medical device design. He has worked in the aerospace and defense industries, the automotive industry, and the medical device industry. He co-founded the Biomechatronics Group in the Harvard-MIT HST program in the original MIT Artificial Intelligence Laboratory, where he 

A.G.E.s are extremely damaging to our health. You are wise to become "A.G.E. aware".

A.G.E.s is an acronym for Advanced Glycation End-products or "glycation". Most people wrongly think A.G.E.s is only a problem for people with a high HbA1c score measuring average blood glucose levels over the last 3 months. A.G.E.s affect us all. A.G.E.s are now known to be a cause of cancer and of many chronic diseases, including: type 2 diabetes, heart disease, painful joints, erectile disfunction, cataracts, and even wrinkling of the skin.

Our bodies make A.G.E.s as an unavoidable consequence of making energy to live, and we eat foods containing a wide range of A.G.E volumes. Avoiding the A.G.E.s in our food is the easiest way to control the accumulation of A.G.E.s. The volume of AGEs in our food is dependent upon the type and amount of food and how it is prepared. Cooking food slowly, wet, with acidic marinades (such as lemon, lime, tomato sauce, vinegar, wine) and/or certain spices (such as Indian) makes all the difference. Eating food raw is even better. And regular exercise may be the only way to reduce the retention of A.G.E.s.

The Anti-A.G.E. Foundation says research suggests up to 30% of the A.G.E.s we consume in our food remains inside our bodies. Over our lifetime, very slowly these A.G.E.s build up in our tissues. Very slowly but very surely. The organs of a 50 year old will have far more A.G.E.s than a 20 year old. Initial studies in healthy individuals suggest that consumption of 15,000 to 20,000 A.G.E.s per day may be a healthy limit, as the body can detoxify some amount of A.G.E.s. But research has not concluded a safe level, so “less is more” applies. 

15,000 A.G.E.s may sound like a lot but a single fast-food meal contains 22,000 A.G.E.s. Fried, grilled, and baked foods...and in particular fatty meats ... generate the most A.G.E.s.

Learn about A.G.E.s from Dr Turner's TEDx Talk: https://youtu.be/LvwMXqyrKG0?feature=shared

Dr. David Turner is President & Co-Founder Anti A.G.E Foundation (non-profit) and Vice Chair of Research in the Department of Surgery at the Virginia Commonwealth University Massey Cancer Center. His strong British accent was honed growing up in the North of England where he completed his Honors Science Degree in Molecular Biology and Doctorate in Biochemistry at the University of Newcastle in the United Kingdom. His passion is combining his scientific research on A.G.E.s with a total commitment to making the world “A.G.E. aware”.  

Dr. Victoria Findlay is a Co-Founder of Anti-A.G.E. Foundation (non-profit) and is an Associate Professor in the Department of Surgery and a Co-Leader of the Cancer Prevention & Control Program at the Massey Cancer Center at the Virginia Commonwealth University. She earned her BSc in Edinburgh, Scotland and her doctorate in Genetics at the University of Newcastle in England. Her passion is to educate and inspire the next

Recovery from too much exercise or stress in life can be a hard problem to solve. Trying hard to relax is not only an oxymoron but is also impossible. Wise Athletes need some external signal to trigger our brain's unconscious program for relaxation and recovery. This is critical for athletic performance as well as for longevity.

Listen in as Don Moxley explains how the cannabis plant includes compounds that work with our body's signaling infrastructure to switch on recovery mode, and to resolve anxiety-led sleep interference. If you've tried CBD before but didn't get any benefit, you probably weren't taking a large enough dose. Don also explains the difference between CBD and CBDa, and why CBD is the wrong target. CBDa is what you need for affordable recovery support.

Learn about CBD: https://projectcbd.org/

Mode+Method's HRV+

Don is a regarded longevity science leader known for making the complex simple.

Don Moxley is Director of Applied Science and Brand Development at Longevity Labs Inc. in the United States. Operating with the personal mission of helping individuals understand the changes necessary to alleviate suffering and contribute to the betterment of all people, Moxley draws upon his career as an athlete, a sports scientist, and an instructor to lead and educate on the science of autophagy and longevity.

Throughout his life and career, Moxley has applied science to enhancing well-being. A former captain and Big 10 Championship winner with the Ohio State University wrestling team, Don served as the university’s first sport scientist. By giving athletes the ability to track their progress in strength, cardiovascular and resilience training, he helped the wrestling team win a national title and three Big 10 Championships. He has helped athletes achieve two Olympic metals, four World Championships, seven National Championships and 23 All-Americans.

If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a few minutes and helps more people find the episodes.

And, checkout the discount codes provided by show guests who offer unique products that I or Glen use. Click here: DISCOUNT CODES

Thanks.

Mental fitness is much like physical fitness in many ways. As athletes we are also human beings living in a stressful world. Building mental fitness can come randomly over many years of experience, but structured training can make all the difference. Getting professional help can produce the fastest results, but be sure to have a training plan to get you where you want to do. Listen into Kate Allgood of Quantum Performance, as she explains her approach and answers my questions about how to think about mental fitness and some mental tools to deploy to accomplish specific goals.

Kate delivers mental training solutions to overcome the demands faced by elite athletes and other high performers in the military and business. Kate's life has always involved balancing a healthy body and mind. After a successful athletic career, Kate found her passion for helping others to improve and enhance their mental health and performance. Kate earned two Masters degrees with honors in psychology, specializing in applied sport psychology, and general psychology with a concentration in family psychology. She graduated with distinction for both degrees. And, in 2010 Kate launched Quantum Performance Inc, a high performance coaching firm specializing in the mental training of high performers. Current and past clients have included professional athletes in the MLB, NFL, NHL, AHL, Supercross, PGA, LPGA, skateboarding, the Anaheim Ducks & San Diego Gulls hockey teams, Olympic, college, & high school athletes, Navy SEALs and Marine fighter pilots to ironman triathletes.  And, Kate is the author of 3 books that provide all the details behind her approach.

Multiple levels of framework, from highest level to lowest:

I have a number of amazing episodes coming up (mental strength, CBD, avoiding glycation/AGEs, PEMF and more) but I haven't been able to get any of them ready. It's been too long since I published anything so I thought I'd share an great one from last year done with one of my favorite people, Dr Mike T Nelson. Enjoy!

Dr Mike is a well known expert on Metabolic Flexibility, and I have had him on Wise Athletes twice out of pure admiration for his amazing body of work. On episode #68, Glen and I spoke with Dr. Mike T Nelson about building anti-fragility across a range of physical and mental functions. If you missed this one or the 2021 episode on Metabolic Flexibility, be sure to listen in. If you already heard it, you wouldn't be wasting your time to check out Dr Mike's advice again.

Episode 32: https://www.wiseathletes.com/podcast/32-helping-older-athletes-feel-young-again-via-metabolic-and-physiologic-flexibility-with-dr-mike-t-nelson/

Creator of the Flex Diet Certification & Phys Flex Certification, kiteboarder, lifter of odd objects, metal music lover.  

Dr. Mike's Website https://miketnelson.com

Dr. Mike's Instagram drmiketnelson

The 4 main regulators pH, temp, blood gas oxygen and CO2, and blood glucose. 

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The focus is Body composition and athletic performance, which are intertwined.  Body composition is good for health, self esteem and performance. Athletic performance is good for (1) health (body is built to move), (2) longevity (3 factors) and (3) body composition (burning calories