Giuseppe is a Professor, Eminent Scholar in the Cybersecurity and CCI Faculty Fellow in the Department of Computer Science and the Department of Cyber Security Engineering at George Mason University. He has advanced many areas of research, including proxy re-encryption, anonymous communication, two-party computation, secure storage, and provable data possession.

His current work includes privacy-preserving machine learning and decentralised secure computing based on blockchain technology. He received the NSF CAREER Award for his research on privacy and security, and the Google Faculty Research Award, the IBM Faculty Award, and the IEEE CISTC Technical Recognition Award for his research on cloud security.

Giuseppe was a researcher at IBM Zurich Research lab (Switzerland) and a scientist at the Information Sciences Institute of the University of Southern California (USA), and worked briefly as a visiting professor at Microsoft in Redmond (USA).

He was the Farber Endowed Chair in Computer Science and Department Chair at Stevens Institute of Technology. He previously worked with Sapienza University of Rome (Italy) and was an Associate Professor at Johns Hopkins University (USA). Giuseppe is also one of the JHU Information Security Institute's founders.