Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman introduces the material properties of elasticity and viscosity. He describes two separate experimental setups to measure the elasticity and the viscosity of a material. Material elasticity can be defined in terms of stress-strain property, and defines the Young's modulus (E), which is the slope of the stress-strain curve. Fluid viscosity, on the other hand, is described by shear stress. When modeling any material, the spring can be used to represent an ideal elastic material and the dashpot an ideal viscoelastic material. All biomaterials contain some combination of these properties and can be described by physical models that consist of both spring and dashpot.

00:00 - Chapter 1. Introduction
03:16 - Chapter 2. An Experiment on Elasticity
18:20 - Chapter 3. Viscosity
28:46 - Chapter 4. Deformation and Viscoelasticity
42:13 - Chapter 5. Conclusion

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman reviews the concept of gene therapy, and gives some examples of where this is applied. Methods to help deliver DNA into cells using viruses and cationic lipids are discussed, as a way to overcome some challenges in gene therapy. Next, Professor Saltzman gives a brief introduction into bacterial and mammalian cell physiology. He describes the different tissues in the body, the cell development/differentiation process, the anchorage dependence of mammalian cells that allows them to form an organism, and the extracellular matrix.

00:00 - Chapter 1. Applications of Gene Transfer
06:40 - Chapter 2. Gene Therapy
14:45 - Chapter 3. Potentials and Limits of Hijacking Viruses
22:28 - Chapter 4. Bacterial and Human Cell Physiology
33:43 - Chapter 5. Cellular Division
38:42 - Chapter 6. Cell Differentiation

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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Financial Markets (ECON 252)

Stephen Schwarzman, Co-Founder of Blackstone Group, a private equity firm, speaks about his experience in the industry. He discusses his thoughts on global finance, particularly at such an interesting and challenging point in the history of financial institutions. Although the near future might be rough for the United States and economies around the globe, capital does tend to come back and regulators are busy figuring out how best to put safeguards on the system. He also offers career advice and mentions some of the surprises he came across upon entering the world of finance.

00:00 - Chapter 1. Introduction: Stephen Schwarzman's Profile
03:00 - Chapter 2. In His Own Words: Early Discoveries in the Financial Market
12:36 - Chapter 3. Real Estate Assets Performance with Blackstone
17:16 - Chapter 4. Deconstructing the Subprime Crisis and "Jars of American SARS"
26:53 - Chapter 5. A Recession in the Aftermath: A New Financial World
34:49 - Chapter 6. Questions: Successes and Setbacks
44:54 - Chapter 7. Personal Lessons and Insights from the Financial World
55:44 - Chapter 8. Questions: Dealing with Failure and the Future of Investing and Private Equity

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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The American Novel Since 1945 (ENGL 291)

At the very beginning of the course, Professor Hungerford offered students the opportunity to pitch a novel of their choice to fill the final spot on the syllabus. Today six students rise to that challenge, presenting their arguments for why each book would complete the intellectual trajectory established thus far. While the Teaching Assistants tally the results of the class vote, Professor Hungerford provides some final thoughts about the theme of loss in Marilynne Robinson's Housekeeping. The effacement of the body in this novel, and the beauty of absence and hunger, result in what Hungerford terms an "anorexic aesthetic" that raises problems for feminist interpretation.

00:00 - Chapter 1. Novel Pitch Day
02:03 - Chapter 2. Emma's Pitch: "Giovanni's Room"
06:44 - Chapter 3. Kelsey's Pitch: "One Flew Over the Cuckoo's Nest"
12:25 - Chapter 4. Miranda's Pitch: "Play It As It Lays"
18:06 - Chapter 5. Will's Pitch: "Jesus' Son"
22:31 - Chapter 6. Eli's Pitch: "Everything Is Illuminated"
28:03 - Chapter 7. Roger's Pitch: "What Is the What"
36:30 - Chapter 8 Back to "Housekeeping": The Logic of Absence

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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Professors David Blight, Beverly Gage, and Joanne Freeman discuss Professor Freeman's Week 2 lectures on the Federalists (don't call them papers) and whether anyone would actually like the real Alexander Hamilton.

This podcast is also available on Apple:
https://podcasts.apple.com/us/podcast/america-at-250-the-podcast/id1840422776

and Spotify:
https://open.spotify.com/show/4C8qfQf21r4eO6mVUFguG2

To view all the videos in this course or view and download a copy of the course syllabus with required readings please scroll through the page at this link:
https://president.yale.edu/committees-programs/devane-lectures/america-at-250-a-history

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In this lesson, we dive into the 'career purpose worksheet,' a powerful tool designed to help you articulate the tactical 'why' behind your job hunt. Moving beyond philosophical contemplation, this exercise guides you through critical questions to uncover your non-negotiables and core motivations, ensuring your next career move aligns with what truly matters to you.

🎯 Learning Objectives
• Identify personal "huge or nothing" factors and non-negotiables for your job search.
• Articulate the specific problems you are passionate about solving and who you aim to help.
• Determine your preferences for organizational structure and work dynamics (e.g., best-in-class vs. fixer-upper, consulting vs. client-side).
• Strategically use tactical questions to filter opportunities and clarify your underlying motivations.

📚 About the Course: Navigating a career move can feel overwhelming in today’s dynamic job market. The Hunt offers a practical, structured framework to help you make your next job search intentional, effective, and purpose-driven. Whether you’re starting your career, seeking a new direction, or looking to advance, this course equips you with the tools to clarify your goals, sharpen your pitch, and connect authentically with others. Drawing on strategies tested with hundreds of students and professionals, the course emphasizes how to combine self-reflection, networking tactics, and storytelling to land opportunities that align with your values and strengths. By the end, you’ll walk away with a personalized one-page Hunt Dashboard to guide your ongoing career journey.

🎓 Enroll on Coursera for assessments and a certificate: https://www.coursera.org/learn/the-job-hunt

🌐 Explore more learning opportunities on Yale Online: https://online.yale.edu/

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Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman continues his description of nephron anatomy, and the specific role of each part of the nephron in establishing concentration gradients to help in secretion and reabsorption of water, ions, nutrients and wastes. A number of molecular transport processes that produces urine from the initial ultra-filtrate, such as passive diffusion by concentration difference, osmosis, and active transport with sodium-potassium ATPase, are listed. Next, Professor Saltzman describes a method to measure glomerular filtration rate (GFR) using tracer molecule, inulin. He then talks about regulation of sodium, an important ion for cell signaling in the body, as an example to demonstrate the different ways in which nephrons maintain homeostasis.

00:00 - Chapter 1. Introduction
03:06 - Chapter 2. The Role of the Nephron in Ion Balance
16:54 - Chapter 3. The Glomerular Filtration Rate
26:21 - Chapter 4. Selective Reabsorption
39:51 - Chapter 5. Water Balance and Conclusion

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a drug concentration that is sufficient for therapeutic purpose, but below a toxic level, is emphasized. Since this is directly affected by drug administration method, ways to localize and sustain therapeutic concentrations of drug, such as incorporating in slow-releasing, biocompatible polymers are introduced. Professor Saltzman gave some examples of clinical applications of controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres.

00:00 - Chapter 1. Model for Injected Drug Delivery
08:42 - Chapter 2. Model for Oral Drug Delivery
16:10 - Chapter 3. Drug as Implant: Potentials and Limits
38:46 - Chapter 4. Accessibility of New Drug Delivery Methods

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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In this critical lesson, we delve into the paramount importance of cybersecurity for medical software developers in an era of interconnected devices. Discover why safeguarding information systems from unauthorized activities is not just a technical requirement, but a vital component of patient safety and data integrity, with real-world examples illustrating the devastating impact of breaches.

🎯 Learning Objectives
• Define cybersecurity within the context of medical devices and software.
• Understand the critical importance of cybersecurity for patient safety and data integrity in healthcare.
• Identify key cybersecurity principles and best practices, including authentication, encryption, and the NIST framework.
• Differentiate between FDA's Tier 1 and Tier 2 cybersecurity risk classifications for medical devices.
• Discuss the challenges and considerations for maintaining data security in cloud environments.

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Frontiers of Biomedical Engineering (BENG 100)

Professor Saltzman describes the processes of fertilization and embryogenesis. Professor Saltzman then talks about the definition and classification of different types of stem cells, where stem cells are found in the body, and the potential for use of stem cells in treating diseases. Some challenges in this type of therapy are also discussed. Finally, Professor Saltzman introduces the exponential equation for cell growth, dX/dt = eμt, and the concept of cell "doubling time."

00:00 - Chapter 1. Fertilization and Early Development
11:50 - Chapter 2. Development of Stem Cells
23:26 - Chapter 3. Results of Differentiation
36:52 - Chapter 4. Stem Cell Lineage
44:26 - Chapter 5. Cell Proliferation

Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses

This course was recorded in Spring 2008.

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