Orphan Black has been telling us we have to go back...so we're reviewing the science of Seasons 1 & 2: Neolutionism, stem cells, and more. This is the first of three parts, and we'll be releasing them while covering Season 4.

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Crib notes for Season 4:

Read about Donna Haraway, and Cosima Herter's essay about how Haraway's work influences Orphan Black: 

http://www.bbcamerica.com/shows/orphan-black/blog/2016/04/eat-medrink-me-and-the-trouble-with-cyborgs: Eat Me/Drink Me and the Trouble with Cyborgs


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We're talking about S1E3: How do you solve a problem like Dead Katja? What's the best approach for babysitting? And how hard is self-surgery post-rebar impalement?

Also, we'll give a brief history of fingerprints, and answer the question of whether clones would indeed have identical ones.

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Show Notes

The History of Fingerprints

Beavan, Colin. 2001. Fingerprints: The Origins of Crime Detection and the Murder Case that Launched Forensic Science. New York: Hyperion. (Book that emphasizes Faulds’ role, and really hates Galton.)

Galton.org: Victorian polymath: geographer, meteorologist, tropical explorer, founder of differential psychology, inventor of fingerprint identification, pioneer of statistical correlation and regression, convinced hereditarian, eugenicist, proto-geneticist, half-cousin of Charles Darwin and best-selling author. (Contains all of Galton’s work on fingerprinting, as well as scans of the Nature letters from Herschel, Faulds and Galton. Thinks Faulds was a nobody whiner.)

The forgotten pioneers of fingerprint science, G. S. Sodhi and Jasjeet Kaur, Current Science, 2005. (PDF) http://www.iisc.ernet.in/currsci/jan102005/185.pdf
(Tells the stories of Haque’s and Bose’s contributions to the fingerprint classification system commonly known as the Henry System.)

Adermatoglyphia: The Genetic Disorder Of People Born Without Fingerprints, Joseph Stromberg, smithsonian.com, January 14, 2014.

http://www.smithsonianmag.com/science-nature/adermatoglyphia-genetic-disorder-people-born-without-fingerprints-180949338/?no-ist

The Claim: Identical Twins Have Identical Fingerprints. By ANAHAD O'CONNORNOV. 2, 2004, The New York Times

http://www.nytimes.com/2004/11/02/health/the-claim-identical-twins-have-identical-fingerprints.html?_r=0

Wikipedia

Fingerprint

https://en.wikipedia.org/w/index.php?title=Fingerprint&oldid=704300924

The Sepoy Rebellion/Indian Rebellion of 1857

https://en.wikipedia.org/wiki/Indian_Rebellion_of_1857

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Episode 2 of our Spoiler Free Rewatch ramps up the drama, and brings Sarah Manning within striking distance of the answers she's been seeking. Little does she know, it just gets weirder from here.

Now that the Season 4 teasers have come out, it's time to rewatch Orphan Black until the April premiere! Join us for our Spoiler Free Episodes to tide you over until then. 

This episode covers Season 1, Episode 1: Natural Selection, or Welcome Home, Sarah Manning!

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Show Notes

Charles Darwin Online:

http://darwin-online.org.uk

On the Origin of Species By Means of Natural Selection, &c.: 

http://darwin-online.org.uk/EditorialIntroductions/Freeman_OntheOriginofSpecies.html

EvoWiki: Discussion of Darwin and Racism
http://evolutionwiki.org/wiki/Darwin_himself_was_racist

Wikipedia: Scientific Racism
http://en.wikipedia.org/wiki/Scientific Racism

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Waiting for the return of Orphan Black is hard. We want to help.

This is the first part of our survival series, offering shows to watch when you're not rewatching (Orphan Black.)

NOTE: Episode 10B will be the first in our Rewatch series, covering Season 1, Episode 1: Natural Selection.

Show Notes:

Wired: Is Sense8 Too Radical For Critics?

Dark Angel — Official FOX Trailer (2000)

https://www.youtube.com/watch?v=P8kkHMJyOYI

Utopia Trailer Channel 4 UK (2013)

https://www.youtube.com/watch?v=r3gxwIqqzB4

Sense8 Trailer — Netflix (2015)

https://www.youtube.com/watch?v=iKpKAlbJ7BQ

Mr Robot Trailer — USA

https://www.youtube.com/watch?v=Ug4fRXGyIak

Humans Trailer — AMC

https://www.youtube.com/watch?v=eb2RTxKnmn8

In which we deal with our sadness at the end of Season 3, discuss the etymology of "neolution", talk about what our plans for the off-season are (hint: biweekly episodes, a rewatch of the series and the science never stops) and give a few more candidates for Season 4 episode title sources.

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Things we mention in the episode:

Anti-Intellectualism in American Life : Richard Hofstadter

The Immortal Life of Henrietta Lacks : Rebecca Skloot

The Tuskegee Syphillis Experiment

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In which we wonder about why John Sadler had to die, discuss how hard it was to watch S03E09, and then explain mosaicism, chimerism and why mothers always have their children close to their internal organs.

Also: Shout outs to Tatiana is Everyone and Science Vs. Hollywood.

Enjoy the finale!

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CSI Chimera Episode and Blaschko’s Lines:
http://genetics.thetech.org/ask/ask75

Chimeras, Mosaics and Other Fun Stuff:

http://genetics.thetech.org/genetic-categories/chimeras-mosaics-and-other-fun-stuff

Blood Group Chimerism In Human Multiple Births Is Not Rare:

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.149.9001&rep=rep1&type=pdf (PDF File)

“Pregnancy may thus establish a long-term, low-grade chimeric state in the human female.”

Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC40117/

Y-chromosome DNA Is Present in the Blood of Female Dogs Suggesting the Presence of Fetal Microchimerism:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068114 (open access)

Tatiana is Everyone: An Orphan Black Podcast

Science Vs Hollywood

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In which we briefly consider why Cosima hates to be the patient and whether the next faction hails from Cambridge, MA, then give you a crash course in proteins, prions and biochemistry. There will not be a test, but there are some handouts if you want them:

Conspiracy Maps: Leda Clones & Castor Clones

Proteins and Prions: UCSF Medical Center

Prions: On The Trail of Killer Proteins

Wikipedia: Prion

Stanley Pruisner's Nobel Lecture on Prions

Also, if you have a suggestion for the source of next season's episode titles, let us know. The poll will be available on our website and Facebook Page on Monday June 15th.

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Episode 005 - Chekhov's Uterus

In which we review Season 3, Episode 7 Community of Dreadful Fear and Hate and use Chekhov's Gun as a somewhat strained device to link Donnie's menstrual flow monitoring, Cosima's relapse, Shay's (possibly triggering) smoothies, and why you don't want to check your urine for misfolded proteins.

Next episode: Misfolded Proteins and Prions, Oh My.

Links:

Learn more about histology and epithelium at:

http://www.histology-world.com/contents/contents.htm#epithelium 

More advanced information at:

http://medcell.med.yale.edu/histology/epithelia_lab.php

Excellent overview of endometriosis:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072685/

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Episode 004: Paul is Dead Now, Miss Him, Etc.

Show Notes

This episode is brought to you by Mercury Retrograde. Drive one today!

In which we miss Paul, wonder aloud about clones and dominant handedness, and begin a longer conversation (to be picked up in the next non-episode episode) about proteins, prions and disease.

Alchemical symbols (as seen in The Island of Dr. Moreau and the Blue Period paintings of Rachel Duncan):

http://alchemicaldiagrams.blogspot.com/2011/10/alchemy-symbols-with-meanings.html

Genes and Handedness

http://www.geneticliteracyproject.org/2014/12/02/left-handedness-genes-and-a-matter-of-chance/

HOMEWORK!

If you’re interested in boning up before Episode 6 - Misfolded Proteins and Prions, Oh My! here is an article to start reading. It’s a good overview with introductory material.

Protein Misfolding and Neurodegenerative Diseases
http://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929

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Thanks for listening!