Vector-borne diseases are among the most complex of all infectious diseases to prevent and control. In recent years, several viruses have spread to new regions and immunologically naïve populations, with significant implications for local populations and international travelers. Zika virus is primarily transmitted to humans via several species of Aedes mosquitoes and can cause symptoms of fever, joint pain, rash, conjunctivitis, muscle aches, and headache. Most Zika virus infections are asymptomatic or are associated with a short course of mild illness, but severe health outcomes are also associated with this pathogen. Zika virus infection during pregnancy can cause microcephaly and other severe fetal brain defects. This session will look at the World Health Organization’s Zika virus country classification categories, discuss the CDC travel guidance for countries with risk of ZIka, and look at principles underlying CDC’s travel recommendations.