Guest host Catherine Jenkinson interviews Mr. Jefferson about addiction, alcoholism, and depression in the early American republic. Jefferson explains that there were no treatment programs in his time for either mental illness or addiction. The insane asylums of the time were unspeakably horrible. Jefferson was well aware of the problems of alcoholism, because his protege Meriwether Lewis descended into substance abuse in the aftermath of the Lewis and Clark Expedition; and Jefferson's grandson-in-law, Charles Bankhead, was a drunk who physically abused his wife Anne Cary Randolph Bankhead. Jefferson's own consumption habits open the program with his usual position that moderate consumption of wine is the right approach to life.

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Thomas Jefferson is interpreted and portrayed by Clay S. Jenkinson.