LEVITY

#18 Aubrey de Grey | The Big 2025 Interview


Listen Later

In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.


You'll also hear about:

His predictions for reaching Longevity Escape Velocity by the late 2030s

What he would change about Bryan Johnson's longevity algorithm

How reaching RMR could trigger a global "war on aging"

Why AI won't solve aging without proper experimental data

How Demis Hassabis is the smartest person Aubrey's ever met

His involvement in designing the XPRIZE Healthspan competition

His rebuttal to Mark Hamalainen's "replacement strategy" approach

The divide-and-conquer approach to aging and why it's superior


🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


-- CHAPTERS --

00:00 Introduction and Welcome

03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies

12:05 The Robust Mouse Rejuvenation Studies

18:10 Latest Results from the Mouse Rejuvenation Experiments

25:42 Reaching RMR soon and LEV in 12-15 years

33:47 Healthspanners in public - lifespanners in private?

37:03 The Replacement Strategy Debate with Mark Hamalainen

45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain

54:46 Advanced bioengineering

57:34 The Debate with Peter Fedichev

01:11:57 Understanding Aging from an Evolutionary Perspective

01:17:05 Artificial Intelligence and Longevity Research

01:26:42 Is believing in AI hopium?

1:28:27 Aubrey’s Involvement in the XPRIZE Healthspan Competition

1:38:56 Special Economic Zones and Regulatory Challenges

1:47:27 What Aubrey would do with Bryan Johnson’s algorithm

1:50:49 What Excites Aubrey Most About the Future

1:51:57 Book Recommendations and Closing Thoughts

Hosted on Acast. See acast.com/privacy for more information.

...more
View all episodesView all episodes
Download on the App Store

LEVITYBy Peter Ottsjö

  • 5
  • 5
  • 5
  • 5
  • 5

5

1 ratings


More shows like LEVITY

View all
The Human Upgrade: Biohacking for Longevity & Performance by Dave Asprey

The Human Upgrade: Biohacking for Longevity & Performance

7,204 Listeners

FoundMyFitness by Rhonda Patrick, Ph.D.

FoundMyFitness

5,307 Listeners

The Jesse Chappus Show by Jesse Chappus

The Jesse Chappus Show

1,544 Listeners

Heart Doc VIP with Dr. Joel Kahn by Dr. Joel Kahn

Heart Doc VIP with Dr. Joel Kahn

489 Listeners

The Empowering Neurologist Podcast by David Perlmutter

The Empowering Neurologist Podcast

408 Listeners

The Genius Life by Max Lugavere

The Genius Life

4,813 Listeners

Dhru Purohit Show by Dhru Purohit

Dhru Purohit Show

3,529 Listeners

The Dr. Hyman Show by Dr. Mark Hyman

The Dr. Hyman Show

9,367 Listeners

The Peter Attia Drive by Peter Attia, MD

The Peter Attia Drive

7,953 Listeners

Dr. Jockers Functional Nutrition by Dr. Jockers

Dr. Jockers Functional Nutrition

752 Listeners

LONGEVITY with Nathalie Niddam by Nathalie Niddam

LONGEVITY with Nathalie Niddam

280 Listeners

Longevity by Design by Gil Blander PhD

Longevity by Design

183 Listeners

The Metabolic Link by Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field

The Metabolic Link

100 Listeners

Your Brain On by Drs. Ayesha and Dean Sherzai

Your Brain On

309 Listeners

Extend Podcast with Darshan Shah, MD by Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

54 Listeners