Admiral James “Sandy” Winnefeld, a non-resident senior fellow at the Kennedy School’s Belfer Center, knows firsthand the damage inflicted by the ongoing opioid crisis. After losing his son to addiction in late 2017, he has committed himself to finding solutions to the seemingly intractable public health dilemma. He discusses his recently-launched foundation Stop the Addiction Fatality Epidemic (SAFE) and the six strategies they are pursuing from awareness to prevention to treatment.