Sir Richard Peto is Emeritus Professor of Medical Statistics and Epidemiology at the University of Oxford. He has helped to reduce the premature deaths of tens of millions of people across the world with his research into smoking, breast cancer, and heart attacks. Here he explains his methods, details his pioneering work in statistics, and outlines improvements he'd like to see in his field. This is a rare chance to hear from one of the world's most impactful epidemiologists.