The schedule is set! Ryan Wilson and John Breech team up to dissect all angles of the 2021 NFL slate. 2/3 of the Pick Six Superfriends examine notables like the season opener between the Cowboys and Bucs, Tom Brady's return game vs. the Patriots, and some big matchups for the Chiefs. The guys also cover the holiday slate and primetime schedule, evaluating the best matchups for Monday Night Football, Sunday Night Football and Thursday Night Football. What are the games you won't want to miss? The crew has you covered with this instant reaction.

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