Scoliosis is commonly viewed as a structural issue of the spine, but the visible curve is often the final expression of deeper, systemic factors. In this episode, we focus on genomics and how it shapes both the likelihood of developing a curve and the way the body responds to treatment.

We discuss how:

Scoliosis is not primarily a spine problem (the curvature is the last thing that shows up)

A collection of genetic variants can increase the likelihood of curve development during rapid growth

Melatonin and serotonin pathways play a role in both postural reflex control and bone modulation

Genomic patterns help explain why two people with the same curve type often respond very differently to braces, exercise, therapy, or surgery

Long-term correction requires addressing the underlying reasons the curve formed, not just the visible structure

Genomics allows us to evaluate predetermined risk, personalize treatment strategies, and understand the origin of the curve rather than only managing its appearance.