CRISPR is a family of DNA sequences in bacteria and archaea that are a part of these organisms' cellular defense system. A recent discovery showed how this mechanism can be used to edit genes much more easily than legacy methods. In this episode I chat with Sam Sternberg about the naturally occuring CRISPR systems, how they work, and how CRISPR together with its associated enzymes can be used to cut, and subsequently, edit, DNA. We conclude the episode with an outlook on the potential use in medicine.