3 Minute 3Rs

In this month's podcast, we're highlighting the papers recognized by the NC3Rs International Prize, with topics including in silico modeling to predict cardiac drug toxicity, a novel experimental design to reduce variability, and affimers as an alternative to antibodiesRead more about the Prize and the research here: https://www.nc3rs.org.uk/3rsprizewinners

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In this month's 3-minute 3R's, we're talking temperature, environmental enrichment to improve stress responses in zebrafish, and better ways to handle mice.The papers behind the pod:Mice Housed at Elevated Vivarium Temperatures Display Enhanced T-cell Response and Survival to Francisella tularensis: http://www.ingentaconnect.com/content/aalas/cm/2017/00000067/00000006/art00004Heat or Insulation: Behavioral Titration of Mouse Preference for Warmth or Access to a Nest: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032799International survey on the use and welfare of zebrafish Danio rerio in research: http://onlinelibrary.wiley.com/doi/10.1111/jfb.13278/abstractEnvironmental enrichment modulates the response to chronic stress in zebrafish: http://jeb.biologists.org/content/early/2018/01/09/jeb.176735Handling method alters the hedonic value of reward in laboratory mice: https://www.nature.com/articles/s41598-018-20716-3The pod was produced this month with contributions from Lab Animal (www.nature.com/laban), the NC3Rs in the UK (www.nc3rs.org.uk), and the North American 3Rs Collaborative (www.na3rsc.org).

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In this month's 3-minute 3Rs: A review on using zebrafish embryos to help improve nano-toxicology studies (http://www.tandfonline.com/doi/abs/10.1080/10408444.2017.1404965?journalCode=itxc20)Turning plain language summaries of animal experiments into analyzable data (http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003217)And, a new protocol for making knockout mice in a single generation (https://www.nature.com/articles/nprot.2017.110)Find out more at Lab Animal (www.nature.com/laban) or the NC3Rs (NC3Rs.org.uk).

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3 minute 3Rs, brought to you by Lab Animal at Nature Research and the NC3Rs in London, is a quick monthly podcast summarizing the latest research and news in 3Rs Science and Technology. In this month's podcast:A "transparent ribcage" for imaging tumor dynamics with cellular resolution in murine lungs (https://www.nature.com/articles/nmeth.4511)The future of tissue chips for improving drug discovery (https://doi.org/10.1177/1535370217715441)Robotic zebrafish for probing social behavioral (http://iopscience.iop.org/article/10.1088/1748-3190/aa8f6a)

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In this month's interview, we're chatting with Sarah Moore, a veterinarian and researcher at the Ohio State University. Sarah studies spinal cord injury, an often debilitating condition that affects thousands of people as well as pets each year. We talk about Sarah's work and why she thinks the search for treatments to help our canine companions living with spinal cord injuries - termed spontaneous dog models - could also help human patients.

3 minute 3Rs, brought to you by Lab Animal at Nature Research and the NC3Rs in London, is a quick monthly podcast summarizing the latest research and news in 3Rs Science and Technology. This month, we look at rodent big brother for 24/7 remote monitoring of rodent behavior, the alliance of genome resources, and the experimental design assistant for improving the rigor and reproducibility of animal research.

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